Translational Research Training in Hepatology

肝病学转化研究培训

• 批准号: 10620808
• 负责人: Rohit Kohli
• 金额: $ 26.18万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620808
• 关键词: Hepatology; Research Training; Translational Research

Summary/Abstract: This application to establish a postdoctoral T32 training program in Translational Research in Hepatology to be administered at the University of Southern California (USC) Keck School of Medicine in conjunction with the Children's Hospital Los Angeles (CHLA), with affiliations at the USC Schaeffer Center for Health Policy and Economics. This training program leverages substantial university and department level investments in research infrastructure and faculty recruits, a steady rise in the quality of the training-grant-eligible applicant pool and the rich diversity of patient populations in Los Angeles to provide a robust research training experience. This Program is focused on training physician-scientists who are accepted to USC/CHLA Gastroenterology fellowships and will provide up to 3 years of support for intensive laboratory or clinical research training and mentored research for 10 MD (or MD/PhD) trainees over five years. Trainees will conduct laboratory, clinical and/or translational research (T1-T4 spectrum) under the mentorship of 16 highly qualified research mentors who have a solid track record of NIH (NIDDK) funding and exceptional mentoring accomplishments. Research themes of (i) Hepatic Immunology, Injury and Regeneration; (ii) Hepatic Steatosis and Fibrosis; and (iii) Clinical Outcomes and Community/Healthcare Implementation reflect the research strengths and training opportunities within well-established research collaborations at USC/CHLA. An individualized curriculum will focus on building each trainee’s research knowledge base, critical investigative abilities and technical skills, with diligent oversight of the training progress by primary mentors, as well as mentoring and executive committees. The institutional environment at USC/CHLA and affiliates provides abundant resources (research institutes and centers with a wide range of cores), a rich intellectual milieu for training in digestive diseases research including masters’ level training in clinical research methods, and dedicated trainee-mentor activities including an annual fellow-led symposium, biweekly work-in-progress meetings, and monthly journal clubs. Further, this training program occurs in the multi-ethic environment of Los Angeles, providing a unique educational opportunity to study liver diseases in minority populations. The ultimate goal of this T32 Training Program is to prepare GI trainees to assume a faculty-level position and compete successfully for independent research funding across the spectrum of translational liver diseases research to address the significant burden of liver disorders in the U.S. and globally.

摘要/摘要：此应用程序建立翻译研究的博士后T32培训计划 在南加州大学（USC）凯克医学院的肝病学领域 与洛杉矶儿童医院（CHLA）的联系，在USC Schaeffer中心与分支机构 卫生政策和经济学。该培训计划利用了实质性的大学和系一级 研究基础设施和教师报告的投资，培训符合资格资格的质量不断提高 申请人池和洛杉矶的患者人群的丰富多样性，以提供强大的研究培训 经验。该计划的重点是培训被USC/CHLA接受的身体科学家 胃肠病学奖学金，将为密集实验室或临床研究提供多达3年的支持 在五年内，培训并修补了10名MD（或MD/PHD）学员的研究。学员将执行实验室， 在16个高素质研究的指导下，临床和/或翻译研究（T1-T4光谱） 具有NIH（NIDDK）资金和出色指导成就的良好记录的导师。 研究主题（i）肝免疫学，伤害和再生； （ii）肝脂肪变性和纤维化；和 （iii）临床成果和社区/医疗保健实施反映了研究优势和培训 在USC/CHLA建立良好的研究合作中的机会。个性化的课程将 专注于建立每个学员的研究知识库，批判性调查能力和技术技能，并具有 主要导师以及心理和执行委员会对培训进度的勤奋监督。 USC/CHLA和分支机构的机构环境提供了丰富的资源（研究机构和 具有广泛核心的中心），这是一个丰富的智力环境，用于消化疾病研究的培训 大师赛在临床研究方法中的水平培训以及专门的实习生活动，包括年度 领导的研讨会，每两周工作的会议和每月期刊俱乐部。此外，这项培训 计划发生在洛杉矶的多伦理环境中，提供了独特的教育机会 研究少数族裔人群的肝病。该T32培训计划的最终目标是准备GI 受训者可以担任教职员工职位，并成功争夺整个独立研究资金 翻译的肝脏疾病研究的范围，以解决肝脏疾病的大量灼伤 美国和全球。

项目成果

A Case of Pediatric Alcohol-Associated Hepatitis Evaluated for Liver Transplant Listing.

• DOI: 10.1097/pg9.0000000000000311
• 发表时间: 2023-05
• 期刊: JPGN reports

Recurrent Rectal Prolapse Successfully Treated With Polyethylene Glycol.

• DOI: 10.1097/pg9.0000000000000380
• 发表时间: 2023-11
• 期刊: JPGN reports

Elevated liver enzymes: unusual presentation of anti-MDA5 antibody-associated juvenile dermatomyositis.

肝酶升高：抗 MDA5 抗体相关幼年皮肌炎的异常表现。

• DOI: 10.55563/clinexprheumatol/25znui
• 发表时间: 2024
• 期刊: Clinical and experimental rheumatology
• 影响因子: 3.7
• 作者: Yi,BelinaY;Marrs,Joshua;Schenker,Rachel;Suddock,Jolee;Cotter,JenniferA;Cidon,Michal
• 通讯作者: Cidon,Michal