Biostatistics/Epidemiology Core

生物统计学/流行病学核心

• 批准号: 10242675
• 负责人: GLEB R HAYNATZKI
• 金额: $ 0.08万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2021-10-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10242675
• 关键词: AIDS related cancer; Acquired Immunodeficiency Syndrome; Archives; Area; Biological; Biometry; Clinical Data; Clinical Management; Clinical Research; Collection; Complex; Computerized Medical Record; Consultations; Core Facility; Data; Data Analyses; Data Analytics; Data Collection; Data Reporting; Data Set; Databases; Development; Diagnosis; Disease; Educational workshop; Elements; Ensure; Epidemiologic Methods; Epidemiology; Experimental Designs; Future; Generations; Goals; Grant; Guidelines; HIV-1; Hospitals; Laboratories; Laboratory Research; Laboratory Study; Malignant Neoplasms; Manuals; Manuscripts; Measures; Mentors; Mentorship; Methodology; Modeling; Paper; Pathogenesis; Phase; Pilot Projects; Practice Management; Protocols documentation; Publications; Quality Control; Questionnaire Designs; Records; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Sample Size; Services; Statistical Data Interpretation; Statistical Methods; Teaching Hospitals; Testing; Training; Training Support; Transferable Skills; United States National Institutes of Health; Universities; Update; Zambia; anticancer research; career; complex data; data management; data quality; database design; design; epidemiology study; innovation; meetings; neoplasm registry; peer; peer coaching; programs; prospective; research study; skill acquisition; success; user-friendly; wasting

STUDY DESCRIPTION/ABSTRACT Despite a focus on the clinical management of HIV-1 and HIV-1 associated malignancies, the University Teaching Hospital (UTH) and the Zambia Cancer Diseases Hospital (CDH) in Lusaka currently lack research infrastructure and expertise for epidemiology and biostatistics. Thus, the establishment of a Biostatistics and Epidemiology Core facility is essential to support the training, research, and capacity-building emphasis of the proposed Zambia AIDS Malignancies Diagnosis and Pathogenesis Program (ZAMDAPP). Such a core is critical in the design of high quality research studies that are precise, accurate, and rigorous. The service provided by the core will include consultation in study design concepts, establishing study size to achieve statistical power, data management practices and quality controls, and statistical analysis of complex data sets to answer current and future research questions. These services will be provided to the two consortium- supported research projects as essential elements of successful project implementation. It will also be imparted to Zambian trainees and to the recipients of ZAMDAPP pilot projects, and ultimately to all cancer researchers at UTH and CDH, an overall goal of expanding Zambian research infrastructure and expertise. As such, the goals of the core are to provide experimental design and implementation support in developmental phases for the research projects and pilot projects and meet data analysis needs of the research and future pilot projects, including: statistical data analyses, descriptive analysis, hypothesis testing, estimations, modeling, generation of statistical reports, development of materials for presentation, and publication of study findings. Finally, the core will prioritize training and skills transfer by organizing workshops related to relevant biostatistics and epidemiological needs in cancer research and HIV-1 associated malignancies, by conducting regular meetings, facilitate progress with data collection, quality controls and analysis, and by contributing to the Career Enhancement Core by providing expertise, resources and facilitation for peer-to-peer mentoring sessions focused on epidemiology and biostatistics.

研究描述/摘要 尽管专注于HIV-1和HIV-1相关的恶性肿瘤的临床管理，但该大学 卢萨卡的教学医院（UTH）和赞比亚癌症疾病医院（CDH）目前缺乏研究 流行病学和生物统计学的基础设施和专业知识。因此，建立生物统计学和 流行病学核心设施对于支持培训，研究和能力建设的重点至关重要 拟议的赞比亚AIDS恶性肿瘤诊断和发病程序（Zamdapp）。这样的核心是 对于精确，准确和严格的高质量研究设计至关重要。服务 由核心提供的将包括对研究设计概念的咨询，建立研究规模以实现 统计能力，数据管理实践和质量控制以及复杂数据集的统计分析 回答当前和未来的研究问题。这些服务将提供给两个财团 - 支持研究项目是成功实施项目的基本要素。也将是 授予赞比亚学员和Zamdapp飞行员项目的接受者，并最终授予所有癌症 UTH和CDH的研究人员，这是扩大赞比亚研究基础设施和专业知识的总体目标。作为 这样的核心目标是在发展中提供实验设计和实施支持 研究项目和试点项目的阶段，并满足研究和未来的数据分析需求 试点项目，包括：统计数据分析，描述性分析，假设测试，估计， 建模，统计报告的产生，开发材料供介绍和出版 发现。最后，核心将通过组织与相关的研讨会来优先考虑培训和技能转移 癌症研究和HIV-1相关的恶性肿瘤的生物统计学和流行病学需求，通过进行 定期会议，促进数据收集，质量控制和分析以及通过 通过为点对点指导提供专业知识，资源和便利化来提高职业增强核心 会议的重点是流行病学和生物统计学。