Clinical Core

临床核心

• 批准号: 8329981
• 负责人: Joseph J Eron
• 金额: $ 34.51万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8329981
• 关键词: AIDS Malignancy Consortium; AIDS clinical trial group; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Acute; Advocate; Applications Grants; Area; Behavioral; Behavioral Research; Blood; Cancer Center; Caring; Centers for Disease Control and Prevention (U.S.); Clinic; Clinical; Clinical Research; Collaborations; Communities; Complex; County; Coupled; Criminal Justice; Data; Databases; Development; Discipline; Drug Formulations; Early treatment; Epidemiologist; Epidemiology; Evaluation; Face; Faculty; Feedback; Fostering; Genotype; Goals; Grant; Growth; HIV; HIV Infections; Health; Health Services Research; Housing; Human Resources; Individual; Industry; Institutional Review Boards; Instruction; International; Joints; K-Series Research Career Programs; Laboratories; Lead; Leadership; Link; Malignant Neoplasms; Manuscripts; Mentors; Mentorship; Methods; Molecular; North Carolina; Pathogenesis; Patients; Population; Populations at Risk; Postdoctoral Fellow; Prema; Prevention; Research; Research Design; Research Personnel; Research Priority; Research Project Grants; Research Support; Resources; Risk; Role; Sampling; Scientist; Screening procedure; Services; Specimen; Strategic Planning; Students; Surveys; Testing; Tissues; Training; Translational Research; United States National Institutes of Health; Work; base; biobank; cohort; design; epidemiological model; experience; graduate student; improved; innovation; meetings; neoplasm registry; patient oriented; population based; programs; repository; research study; skills; success; translational study; transmission process; willingness

PROJECT SUMMARY (See instructions): The Clinical Core of the FHI/RTI/UNC CFAR is led by Dr. Joseph Eron, Director, Dr. Prema Menezes, co-Director, and Dr. Sonia Napravnik, Core Epidemiologist, who also leads the UNC CFAR HIV Clinical Cohort (UCHCC). The goals of the Clinical Core are 1) to enhance the clinical, translational and epidemiological research capacity of a diverse array CFAR investigators by providing essential services such as subject recruitment, sample access and regulatory assistance, study design and management, study coordinator services and unique resources such as access to a detailed clinical cohort with links to larger cohorts and specimen and tissue repositories coupled with state-of-the-art epidemiological expertise and 2) to provide leadership and foster collaboration in high priority research areas and provide mentorship to students and faculty and educational opportunities to the wider community. The Core includes a dedicated staff of over 15 individuals with the needed skills to accomplish these goals. The Core is housed centrally on the UNC Health Affairs campus and is easily accessible to investigators either because of close proximity or because the leadership and several of our services are readily available electronically facilitating interactions with FHl, RTI and international investigators. The Core supports research from molecular to geographic (even combining the extremes) using methods ranging from patient oriented qualitative work to complex epidemiological modeling. Over the past four years the Core served over 100 investigators on over 150 projects supported by the NIH, the Agency for Health Care Research and Quality (AHRQ) and CDC among others. The Core supports multiple CFARiCFAR research projects and NIH-sponsored HIV networks while having a strong mentoring presence. The Core also provides data, leadership and investigator access to two large HIV-focused collaborative cohorts. The Clinical Core is essential for the continued success of the UNC/FHI/RTI CFAR as the services and research opportunities provided by the Core and the UCHCC have proved invaluable to investigators and are not duplicated by other Cores or facilities on the UNC, FHl or RTI campuses.

项目摘要（参见说明）： FHI/RTI/UNC CFAR 的临床核心由主任 Joseph Eron 博士、联合主任 Prema Menezes 博士和核心流行病学家 Sonia Napravnik 博士领导，她还领导 UNC CFAR HIV 临床队列 (UCHCC) ）。临床核心的目标是 1) 通过提供受试者招募、样本获取和监管援助、研究设计和管理、研究等基本服务，增强多样化 CFAR 研究人员的临床、转化和流行病学研究能力。 协调员服务和独特的资源，例如获得详细的临床队列，并链接到更大的队列和样本和组织存储库，再加上最先进的流行病学专业知识，2) 在高度优先的研究领域提供领导和促进合作，并提供对学生和教师的指导以及对更广泛社区的教育机会。核心包括一个专用的 超过 15 名具备实现这些目标所需技能的员工。该核心位于北卡罗来纳大学卫生事务部校园的中心，调查人员可以轻松访问该中心，因为距离很近，或者因为领导层和我们的一些服务可以随时通过电子方式获得，从而促进与 FHl、RTI 和国际调查人员的互动。 核心支持从分子到地理（甚至结合极端）的研究，使用从以患者为导向的定性工作到复杂的流行病学建模等方法。在过去四年中，核心为 100 多名研究人员提供了 NIH（美国卫生署）支持的 150 多个项目的服务 护理研究和质量 (AHRQ) 以及 CDC 等。该核心支持多个 CFARiCFAR 研究项目和 NIH 资助的 HIV 网络，同时拥有强大的指导力量。该核心还为两个以艾滋病毒为重点的大型合作队列提供数据、领导力和研究人员访问权限。 临床核心对于 UNC/FHI/RTI CFAR 的持续成功至关重要，因为该核心和 UCHCC 提供的服务和研究机会已被证明对研究人员来说非常宝贵，并且 UNC、FHl 或 UNC 的其他核心或设施不会重复。 RTI 校园。