Histology Core

组织学核心

基本信息

批准号：
10270975
负责人：
Colin K Combs
金额：
$ 14.28万
依托单位：
UNIVERSITY OF NORTH DAKOTA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-13 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10270975
关键词：
Applications Grants Biomedical Research Businesses Centers of Research Excellence Cities Communities Core Facility Coupled Drops Ensure Equipment Experimental Designs Fee-for-Service Plans Fees Floor Growth Health Sciences Histological Techniques Histology Human Image Image Analysis Infrastructure Institution Instruction Investments Maintenance Morphology North Dakota Nutritional Study Outcome Pathologist Phase Preparation Productivity Publications Recommendation Research Research Personnel Resolution Resources Safety Sampling Services Slide Stains Structure Students Suggestion Techniques Time Tissue Banks Tissue Fixation Tissue Sample Tissues Training United States National Institutes of Health Universities Veterinarians Vision analytical tool base cost detection method fluorescence imaging improved instrument instrumentation medical schools meetings member pathogen programs response sample fixation tissue preparation tribal college undergraduate student whole slide imaging

项目摘要

Summary The Histology Core at UND was established to improve the infrastructure supporting our successful implementation of the Phase 1 Center for Excellence in Host Pathogen Interactions COBRE at the University of North Dakota School of Medicine and Health Sciences. The Core was developed to provide high quality instrumentation, tissue preparation, staining, image analysis services, and training in a wide spectrum of fundamental and advanced histological techniques to COBRE research investigators. The Core also provides access and support to non-COBRE investigators within and outside the UND SMHS, as well as those from institutions adjoining (USDA-Grand Forks Human Nutrition Research Center) and in neighboring cities (North Dakota State University, North Dakota primarily undergraduate institutions and tribal colleges). The Core remains essential for successful growth of the host pathogen interaction enterprise at UND and completing al four of the projects proposed in this Phase 2 renewal application. The Core evolved from being a primarily shared equipment facility with provided user training to now a complete drop off service facility for users across the UND campus. Multiple tissue sectioning and staining services coupled with whole slide brightfield or fluorescent imaging and image quantitation have made the Core invaluable to growth of the research enterprise at UND. In Phase 2, the Core will continue to assist COBRE team members and the broader UND/ND research community with experimental design specifically with regards to application-specific sample preparation techniques, identifying appropriate analytical tools available, resolution restrictions, and quantitative morphological techniques. The Core will also provide service, training, and instruction to COBRE and other users in all aspects of instrument use, safety, tissue sample preparation, and aid with trouble shooting all aspects of tissue preparation and analysis. Finally, the Core will implement a business plan that includes strategies to continue expanding the user base and provide fee-for-service assistance in all aspects of histo- and immunochemical detection methods and analyses, thus paving a way to long-term sustainability of the Core.

概括建立了UND的组织学核心，以改善支持我们成功的基础设施大学期间1阶段卓越中心的宿主病原体互动中心的实施北达科他州医学与健康科学学院开发核心以提供高质量仪器，组织制备，染色，图像分析服务和培训基本和先进的组织学技术针对毛病研究人员。核心也提供访问和支持UND SMH内外的非近代调查人员以及来自毗邻的机构（USDA-Grand Forks人类营养研究中心）和邻近城市（北部北达科他州达科他州立大学主要是本科机构和部落学院。核心对于在UND上成功增长并完成AL仍然是成功的增长在此阶段2更新申请中提出的四个项目。核心从主要是共享设备设施，并提供提供的用户培训，以便为用户提供完整的服务设施和校园。多个组织切片和染色服务以及整个幻灯片Brightfield或荧光成像和图像定量使核心与研究的增长无价企业在und。在第2阶段，核心将继续协助山湾团队成员和更广泛的核心成员 und/nd研究社区，具有针对特定应用的样本专门针对实验设计准备技术，确定可用的合适分析工具，解决方案限制和定量形态学技术。核心还将为山子和其他的服务，培训和教学用户在仪器使用，安全，组织样品准备方面的各个方面以及所有麻烦射击的帮助组织制备和分析方面。最后，核心将执行包括继续扩大用户群并在Histo-的各个方面提供费用的服务援助的策略以及免疫化学检测方法和分析，从而为长期可持续性铺平了一种方法核。