South Texas Alzheimer's Disease Center Research and Education Core

南德克萨斯阿尔茨海默病中心研究和教育核心

• 批准号: 10270733
• 负责人: Jose E Cavazos
• 金额: $ 23.98万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10270733
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Astrocytes; Award; Basic Science; Behavioral; Big Data; Biological Markers; Biology; Biometry; Blood; Blood Pressure; Blood Vessels; Capsicum; Caregiver Burden; Caring; Certification; Clinical; Clinical Trials; Congresses; Data; Dementia; Development; Discipline; Doctor of Philosophy; Doctor' s Degree; Education; Environment; Epidemiology; Epigenetic Process; Face; Faculty; Fostering; Funding; Genetic; Goals; Grant; Growth; Health; Health Knowledge, Attitudes, Practice; Health Professional; Hispanics; Hour; Image; Inflammation; Instruction; Laboratories; Learning; Length; Machine Learning; Magnetic Resonance Imaging; Malignant Neoplasms; Mentors; Metabolic; Methods; Mexican Americans; Microglia; Military Personnel; Mind; Minority; Minority Access; Neurodegenerative Disorders; Neurosciences; Pathway interactions; Pattern; Persons; Plant Roots; Population; Population Sciences; Population Study; Populations at Risk; Positron-Emission Tomography; Prevention; Prevention strategy; Program Effectiveness; Protein Isoforms; Proteomics; Race; Research; Research Personnel; Research Support; Risk; Science; Scientist; Shock; Social Sciences; South Texas; Systems Biology; Tablets; Technology; Time; Training; Translations; Underrepresented Minority; United States National Institutes of Health; Vocational Guidance; Woman; analytical method; aphasia rehabilitation; base; career; cohort; community center; community engagement; connectome; cost; data sharing; dementia care; digital; education research; experience; flexibility; health disparity; healthy lifestyle; improved; insight; lifestyle intervention; metabolomics; minority investigator; mixed dementia; neurocognitive test; neuroregulation; new technology; patient population; peer; person centered; pre-clinical; precision medicine; programs; public health intervention; radioligand; recruit; resilience; risk stratification; senior faculty; social; tau Proteins; treatment strategy

The cost of dementia care in the US will be $1 Trillion by 2050. Moreover, this burden will be highest among minorities, a group that is itself diverse. The Hispanic/Latino population of South Texas, comprised of persons of Mexican American ancestry, is the nation’s fastest growing minority but is woefully under-represented in ADRD research. Reaching and studying this population requires a culturally attuned, highly skilled cohort of researchers and clinicians who recognize that dementia in this group is likely to have different genetic, social, environmental and behavioral risk and resilience factors, heterogenous biology (e.g. greater vascular/metabolic contributions) and care needs (e.g. higher caregiver burden). Expanding the research and clinical workforce will necessitate attracting the brightest minds from related disciplines to dementia research. It also requires being able to recruit, retain and support the career growth of fellows and faculty, with diverse race-, ethnic-, social backgrounds, providing additional, targeted support for promising women and under-represented minority researchers who may lack access to mentoring networks or key information. The Research Education Core (REC) of the STAC, will be a leader in achieving this and sharing our insights nationally. The REC is led by Profs. Cavazos, Maestre and Mahaney who each have deep roots in the Hispanic community and South Texas, a superb track record of successful NIH and VA funding and of academic mentoring especially minority (Hispanic) MD and MD/PhD researchers. They will be supported by other outstanding senior faculty and an impressive cadre of emerging mentors. The REC will offer a 12 credit- hour Graduate Certificate on Dementia and developmental grants to introduce a wide range of health professionals to issues in dementia research. The flagship program of our REC will be to identify and support 9 outstanding faculty candidates, through 2- year K type awards that include a mentored research experience, strong career guidance and culminate in external research funding. Our goal is to grow thought leaders in ADRD research. We propose these Specific Aims: 1) Grow a cadre of researchers representing and/or focusing on all aspects of Hispanic health 2) Broad training across clinical, laboratory, imaging, computational, omics, epidemiology, biostatistics, social science and community engagement domains 3) Emphasis on training clinician, basic and population science researchers to become independent investigators skilled in T1 and T2 translation, team science and mentoring 4) Emphasis on instruction in cutting-edge technologies and analysis methods with a focus on precision medicine approaches and optimal, community and person centered prevention and care. We will carefully evaluate program effectiveness and adjust accordingly. UTHSA and UTRGV are national leaders in Hispanic education and recruitment and the STAC REC will leverage the rich local training environment (AD-RCMAR, CTSI, Pepper, Nathan Shock, GRECC, military research/researchers) to grow superb ADRD researchers.

到2050年，美国的痴呆症护理费用将为1万亿美元。此外，这种烧伤将在 少数群体，本身就是潜水员。南德克萨斯州的西班牙裔/拉丁裔人口由人组成 墨西哥裔美国人的血统是美国增长最快的少数群体，但人数不足 ADRD研究。到达和研究该人群需要一个文化调整，高技能的队列 认识到这一群体痴呆症的研究人员和临床医生可能具有不同的遗传，社会， 环境和行为风险和弹性因素，异质生物学（例如，血管/代谢更大 贡献）和护理需求（例如，更高的护理人员伯恩（Burnen））。扩大研究和临床劳动力 将有必要吸引从相关学科到痴呆症研究的最聪明的头脑。这也需要 能够与潜水，种族，种族，招募，保留和支持研究员和教师的职业发展 社会背景，为承诺妇女提供额外的针对性支持，并且代表性不足 可能无法访问心理网络或关键信息的少数派研究人员。 Stac的研究教育核心（REC）将成为实现这一目标并分享我们的领导者 全国见解。 REC由教授领导。卡瓦佐斯（Cavazos），马斯特（Maestre）和马哈尼（Mahaney）都有深深的根源 西班牙裔社区和南德克萨斯州，成功的NIH和VA资金的出色记录以及 学术精神尤其是少数民族（西班牙裔）医学博士和医学博士/博士学位研究人员。他们将得到 其他杰出的高级教师和令人印象深刻的紧急事务干部。 REC将提供12个学分 - 小时痴呆症和发育补助金的研究生证书，以引入各种健康 专业人士涉及痴呆症研究问题。我们REC的旗舰计划将是识别和支持 9个出色的教师候选人，至2年K型奖项，包括一项指导研究 经验，强大的职业指导并在外部研究资金中达到顶峰。我们的目标是发展思想 ADRD研究的领导者。我们提出了这些具体目的：1）成长一组代表的研究人员 和/或专注于西班牙裔健康的各个方面2）跨临床，实验室，成像， 计算，法学，流行病学，生物统计学，社会科学和社区参与领域3） 强调培训临床，基础和人群科学研究人员成为独立研究人员 熟练T1和T2翻译，团队科学和心理4）强调尖端的教学 技术和分析方法侧重于精确医学方法和最佳社区 以及以人为中心的预防和护理。我们将仔细评估程序有效性并调整 据此。 Uthsa和Utrgv是西班牙裔教育和招聘的国家领导人以及Stac REC将利用丰富的当地培训环境（AD-RCMAR，CTSI，PEPPER，NATHAN SHOCK，GRECC， 军事研究/研究人员）成长出色的ADRD研究人员。