Los Angeles CRS for the MACS/WIHS Combined Cohort Study

洛杉矶 CRS 的 MACS/WIHS 联合队列研究

基本信息

批准号：
10612795
负责人：
Roger Detels
金额：
$ 442.41万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-15 至 2026-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10612795
关键词：
Acquired Immunodeficiency Syndrome Address Adherence Affect African American population Age Aging Alcohols Area Behavior Behavioral Biological Markers Blood Body Composition Brain imaging Cancer Survivorship Cardiac Cardiovascular Diseases Cessation of life Characteristics Cigarette Clinical Clinical Data Cognitive Cohort Studies Collection Data Data Analyses Databases Development Discipline Disease Disease Progression Dropout Elderly Environment Epigenetic Process Etiology Evaluation Event Feces Fostering Fracture Functional disorder General Population Genetic Geography Guidelines HIV HIV Infections HIV Seronegativity Hair Healthcare Healthcare Systems Hispanic Americans Hospitalization Iatrogenesis Immunologics Immunology Incidence Infrastructure Joints Laboratories Laboratory Study Leadership Los Angeles Lung diseases Malignant Neoplasms Measures Mental Depression Modality Molecular Morbidity - disease rate Natural History Neurologic Oral Outcome Participant Pathogenesis Persons Pharmaceutical Preparations Physical Function Physiological Play Process Protocols documentation Psychosocial Factor Publications Research Research Personnel Respiratory Signs and Symptoms Risk Risk Factors Role Sleep Disorders Specimen Standardization Students The Multicenter AIDS Cohort Study Tissues Treatment outcome Urine Viral reservoir Women&apos s Interagency HIV Study antiretroviral therapy biobehavior career career development clinical research site co-infection cohort comorbidity compliance behavior data submission disability experience falls follow-up frailty health care availability health disparity healthy aging innovation men men who have sex with men molecular marker mortality neurocognitive disorder optimal treatments psychologic psychosocial pulmonary function recruit repository sleep quality success tumor working group

项目摘要

Abstract The UCLA Clinical Research Site (CRS) of the Multicenter AIDS Cohort Study (MACS) / Women's Interagency ‐ ‐ ‐‐ HIV Study (WIHS) Combined Cohort Study (CCS) proposes to continue to document clinical, immunologic, ‐‐ ‐ physiologic, behavioral, virologic, genetic and psychosocial changes in HIV infected and uninfected men who ‐‐ have sex with men (MSM). This includes proposed studies to document these changes in MSM recruited ‐ previously, as well as plans to recruit new untreated and recently treated HIV infected MSM (primarily African ‐‐ and Hispanic Americans), to maintain the cohort. The UCLA CRS will provide leadership and participation in the working groups, CCS wide and local studies and research publications, as well as collaborative multi ‐ cohort studies, as it has since the inception of the MACS 35 years ago. The UCLA CRS has recruited a large team of early career and established co investigators from a wide range of disciplines. These investigators have developed, and are continuing to develop, innovative proposals to advance our understanding of co- morbid conditions that arise in people living with treated HIV infection, as well as the pathophysiology, immunology, genetics a‐nd bio-behavioral characteristics of treated and untreated HIV infection. The breadth, enthusiasm, experience and innovation of the UCLA CRS investigators, combined with the experience and commitment of the long term staff, and our leadership of several areas of HIV/AIDs research, will continue to play an invaluable role in the success of the CCS over the next seven years.

抽象的加州大学洛杉矶分校多中心艾滋病队列研究 (MACS) 临床研究中心 (CRS) / Women's Interagency ‐‐‐‐ HIV 研究 (WIHS) 联合队列研究 (CCS) 建议继续记录临床、免疫学、 ‐‐‐ HIV 感染者和未感染者的生理、行为、病毒学、遗传和心理社会变化 --- 与男性发生性关系 (MSM) 这包括记录所招募的 MSM 的这些变化的拟议研究。 - 之前，以及计划招募新的未经治疗和最近接受治疗的艾滋病毒感染男男性行为者（主要是非洲人） --- 和西班牙裔美国人），以维持该群体，加州大学洛杉矶分校 CRS 将提供领导和参与。工作组、CCS 范围内和地方的研究和研究出版物，以及多方协作 - 自 35 年前 MACS 成立以来，加州大学洛杉矶分校 CRS 已招募了大量人员。团队由早期职业生涯和来自广泛学科的联合研究人员组成。已经制定并将继续制定创新提案，以增进我们对合作的理解接受治疗的艾滋病毒感染者出现的病状以及病理生理学，治疗和未治疗的 HIV 感染的免疫学、遗传学和生物行为特征。 UCLA CRS 研究人员的热情、经验和创新，结合经验和长期工作人员的承诺以及我们在艾滋病毒/艾滋病研究多个领域的领导地位将继续为 CCS 在未来七年的成功发挥了不可估量的作用。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Characterization of T Follicular Helper Cells and T Follicular Regulatory Cells in HIV-Infected and Sero-Negative Individuals.

DOI：
10.3390/cells12020296
发表时间：
2023-01-12
期刊：
CELLS
影响因子：
6
作者：
Salvatore, Bradley;Resop, Rachel S.;Gordon, Brent R.;Epeldegui, Marta;Martinez-Maza, Otoniel;Comin-Anduix, Begona;Lam, Alex;Wu, Ting-Ting;Uittenbogaart, Christel H.
通讯作者：
Uittenbogaart, Christel H.

Long-term intra- and inter-individual biological variation of serum lipid of HIV-infected and uninfected men participating in the Los Angeles Multi-Center AIDS Cohort Study (MACS).

DOI：
10.1186/s12944-022-01668-0
发表时间：
2022-07-27
期刊：
LIPIDS IN HEALTH AND DISEASE
影响因子：
4.5
作者：
Aziz, Najib;Gjertson, David W.;Mimiaga, Matthew J.;Azarkman, Chantel D.;Soto, Rey;Alexopoulos, Nicole;Detels, Roger
通讯作者：
Detels, Roger

Relationship among serum levels of IL-6, sIL-6R, s gp130 and CD126 on T-cell in HIV-1 infected and uninfected men participating in the Los Angeles Multi-Center AIDS Cohort Study.