Animal Imaging Shared Resource

动物成像共享资源

• 批准号: 10599138
• 负责人: RICHARD D SCHULICK
• 金额: --
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-04 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10599138
• 关键词: Animal Cancer Model; Animal Model; Animals; Applications Grants; Area; Award; Bioluminescence; Breast Cancer Model; Budgets; Cancer Center; Cancer Center Support Grant; Cancer Model; Cancer Patient; Canis familiaris; Capital; Cellularity; Child; Clinical Trials; Collaborations; Colorado; Consultations; Continuing Education; Contracts; Contrast Media; Dedications; Detection; Development; Diffusion Magnetic Resonance Imaging; Doctor of Philosophy; Education; Educational workshop; Enrollment; Ependymoma; Equipment; Extramural Activities; Faculty; Fees; Fluorescence; Fostering; Funding; Future; Grant; Hand; Human; IACUC; Image; Image Analysis; Imaging Techniques; Imaging technology; Inflammation; Inflammatory; Institution; Leadership; Macrophage; Magnetic Resonance Imaging; Malignant Neoplasms; Manuscripts; Measures; Medical; Mentorship; Metabolic; Mission; Molecular Probes; Multimodal Imaging; Mus; Nanotechnology; Neoplasm Metastasis; Optics; Participant; Patients; Peer Review; Peptides; Physics; Physiology; Positron; Positron-Emission Tomography; Preparation; Protocols documentation; Publications; Publishing; Quality of life; Radioisotopes; Radiology Specialty; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Resource Sharing; Science; Secure; Services; Students; Techniques; Technology; Training; Transgenic Model; Translating; Translations; United States National Institutes of Health; Universities; Update; Validation; Veterinarians; Work; X-Ray Computed Tomography; anatomic imaging; animal colony; animal facility; animal imaging; anticancer research; cancer clinical trial; cancer imaging; cancer survival; companion animal; contrast enhanced; cost; cost effective; diffusion weighted; early phase clinical trial; equipment acquisition; human imaging; image translation; imaging facilities; imaging modality; imaging probe; imaging science; imaging scientist; imaging study; imaging system; in vivo; in vivo imaging system; innovation; instrumentation; interest; iron oxide; member; microCT; microPET; microSPECT; molecular imaging; multimodal neuroimaging; multimodality; nanoparticle; non-invasive imaging; novel; optical imaging; patient derived xenograft model; postpartum breast cancer; pre-clinical; programs; quantitative imaging; quantum; single photon emission computed tomography; treatment response; tumor; tumor progression; ultra high resolution; ultrasound; web page

ABSTRACT Overview: The Animal Imaging Shared Resource (AISR) provides access to state-of-the-art animal scanners and expertise to study tumor progression, metastases, microenvironment and response to therapies using non- invasive imaging in animal models of cancer. The AISR, created in 2006, is the only comprehensive high-end Animal Imaging facility in Colorado. The AISR supports cancer research with high-end imaging services, validation of novel contrast agents, collaboration and training in animal imaging, study design, quantitative image analysis and translation of imaging technologies to human clinical trials. Equipment: Since the last renewal, the AISR worked diligently to leverage extramural and institutional funding to upgrade and maintain cutting edge imaging equipment, resulting in $4.3M in capital equipment investments since 2016. The AISR has added three state-of-the-art preclinical scanners - a Bruker 9.4 Tesla MRI, an IVIS Spectrum, and a Quantum GX2 CT to the existing Siemens Inveon PET/CT, Mediso SPECT/CT, IVIS200 and Bruker 4.7 Tesla MRI. Services and Expertise: The AISR, located within the UCAMC Animal Facilities, offers easy access to advanced imaging equipment and full-service support for imaging studies including study design, IACUC approved protocols, animal handling, image acquisition, multimodal image analysis, and preparation of grant proposals, study reports and publications. In addition to ultra-high resolution (20-50 microns) anatomical imaging, the AISR has established advanced imaging protocols for tumor physiology and microenvironment such as diffusion weighted/ tensor imaging (DWI/ DTI), dynamic contract-enhanced MRI (DCE-MRI), vessel-size imaging (VSI), iron oxide macrophage MRI, metabolic PET and peptide SPECT/CT protocols. Dr. Natalie Serkova, AISR Director since 2006, has developed a robust imaging research infrastructure, based on her MR physics/ animal imaging expertise. Consultation and Education: The AISR offers advanced imaging and image analysis workshops regionally twice per year to enhance researchers' in-vivo study designs. Since 2016, over 300 participants across the State have enrolled in the AISR workshops. Management: The AISR is an institutional shared resource managed by the UCCC. Operating Budget: CCSG funding represents 42% of the current operating budget. Remaining support is from user fees (54%) and institutional support (4%). NIH shared instrumentation grants, matching institutional support and CCSG subsidies are critical to AISR's mission to serve UCCC members at the uppermost level possible while minimizing costs in a relatively expensive technology-centric field. Use of Services: Since 2016, 97 investigators have used the AISR, 42% (n=41) of whom were UCCC members who accounted for 66% of the total use. Future Directions: AISR is working to acquire two new imaging systems, a hands-free ultrasound and an upgraded PET/CT. The added scanners and continuing educational efforts will increase animal imaging applications in studies of tumor detection, microenvironment, and treatment response enhancing cancer research and ultimately the quality of life and survival for cancer patients.

抽象的 概述：动物成像共享资源（AISR）提供了对最先进的动物扫描仪的访问 以及研究肿瘤进展，转移，微环境和对疗法反应的专业知识 癌症动物模型中的侵入性成像。 AISR于2006年创建，是唯一的全面高端 科罗拉多州的动物成像设施。 AISR通过高端成像服务支持癌症研究， 验证新颖的对比剂，动物成像中的协作和培训，研究设计，定量图像 成像技术对人类临床试验的分析和翻译。设备：自上次续签以来 AISR努力地利用壁外和机构资金来升级和保持最前沿 成像设备，自2016年以来产生了430万美元的资本设备投资。 最先进的临床前扫描仪-Bruker 9.4 Tesla MRI，IVIS光谱和量子GX2 CT 现有的西门子Inveon PET/CT，MEDISO SPECT/CT，IVIS200和BRUKER 4.7 TESLA MRI。服务和 专业知识：位于UCAMC动物设施内的AISR可轻松访问高级成像 设备和用于成像研究的全方位服务支持，包括研究设计，IACUC批准的方案， 研究报告 和出版物。除了超高分辨率（20-50微米）解剖成像外，AISR还具有 建立的用于肿瘤生理和微环境的高级成像方案，例如扩散加权/ 张量成像（DWI/ DTI），动态合同增强MRI（DCE-MRI），容器尺寸成像（VSI），氧化铁 巨噬细胞MRI，代谢PET和肽SPECT/CT方案。自从AISR董事Natalie Serkova博士以来 2006年，基于她的MR物理/动物成像，开发了强大的成像研究基础架构 专业知识。咨询和教育：AISR提供高级成像和图像分析研讨会 每年两次区域，以增强研究人员的体内研究设计。自2016年以来，超过300名参与者 该州已参加AISR研讨会。管理：AISR是一种机构共享资源 由UCCC管理。运营预算：CCSG资金占当前运营预算的42％。 剩余的支持来自用户费用（54％）和机构支持（4％）。 NIH共享仪器赠款， 匹配机构支持和CCSG补贴对于AISR为UCCC成员服务的使命至关重要 在相对昂贵的以技术为中心的领域中，最高水平可以最大程度地减少成本。使用 服务：自2016年以来，有97名调查人员使用了AISR，其中42％（n = 41）是UCCC成员 占总使用量的66％。未来的方向：AISR正在努力获得两个新的成像系统，一个 免提超声波和升级的宠物/CT。增加的扫描仪和持续的教育工作将 在肿瘤检测，微环境和治疗反应的研究中增加动物成像的应用 增强癌症患者的癌症研究以及最终的生活质量和生存质量。