Advanced Immunobiology Traning Program for Surgeons

外科医生高级免疫生物学培训计划

• 批准号: 10598547
• 负责人: Allan D. Kirk
• 金额: $ 25.42万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10598547
• 关键词: Immunobiology; Surgeon; programs

Project Summary/Abstract Immunobiology has become increasingly relevant to surgical practice, influencing diverse disciplines including oncology, inflammatory bowel disease, transplantation, trauma and critical care. Although the importance of immune manipulation has become an evident adjunct to surgical practice, surgical training neither includes advanced immunology nor prepares surgeon-scientists to participate in immune-related research. This training grant application seeks funding for the formation of the Advanced Immunobiology Training Program (AITP) at Duke University to create surgeon-scientists capable of participating in and leading surgically relevant areas of immunobiological research. The training program will combine the substantial academic rigor of the Duke University School of Medicine with the Duke Department of Surgery's longstanding and highly successful commitment to training the next generation of surgical researchers. The program will be co-directed by an academic surgeon and a basic sciences researcher, each with expertise in immunology. Supplemented by mentors with expertise in basic, translational, and clinical research, this multidisciplinary team is uniquely qualified to merge basic and applied immunobiology with evolving surgical practice. Program participants will consist of postdoctoral trainees who have completed medical school and initiated surgical residency. At least six individuals will be trained during the proposed funding period. Based on individual development plans, each trainee will choose to participate in either a two- or three-year training program, with opportunities to complete a Master of Health Sciences degree in Clinical Research, or pursue a PhD in Immunology. Trainees will select a primary mentor from a highly experienced and diverse group of 16 basic, translational or clinical immunobiological researchers. Guided by their mentor, they will follow a structured didactic curriculum that will transition to a mentored research experience. A robust research infrastructure and substantial departmental resources will support the students, facilitating their conduct and publication of original investigations with complete protection from clinical service. Specific instruction in immunological investigation will be provided, as will mentorship in scientific writing, publication, ethics and clinical time management.

项目摘要/摘要 免疫生物学已与外科实践越来越相关，影响了包括 肿瘤学，炎症性肠病，移植，创伤和重症监护。虽然重要性 免疫操纵已成为手术练习的明显辅助手术，手术训练都不包括 先进的免疫学也不准备外科医生科学家参加与免疫相关的研究。这个培训 Grant申请寻求资金用于成立高级免疫生物学培训计划（AITP） 杜克大学创建能够参与和领导外科手术相关领域的外科医生科学家 免疫生物学研究。培训计划将结合公爵的严格严格 杜克大学外科部长的大学医学院长期以来的长期成功 致力于培训下一代外科研究人员。该程序将由 学术外科医生和基础科学研究人员，每个研究人员都有免疫学专业知识。补充 具有基础，转化和临床研究专业知识的导师，这个多学科团队是独特的 有资格将基本和应用的免疫生物学与不断发展的手术实践合并。计划参与者会 由已完成医学院并开始手术居住的博士后学员组成。至少 在拟议的资助期间，将对六个人进行培训。根据个人发展计划，每个计划 受训者将选择参加为期两年或三年的培训计划，并有机会完成 临床研究的健康科学硕士学位，或攻读免疫学博士学位。学员将选择 来自经验丰富且多样化的16个基本，翻译或临床的主要导师 免疫生物学研究人员。在他们的导师的指导下，他们将遵循结构化的教学课程 过渡到指导的研究经验。强大的研究基础设施和实质性的部门 资源将支持学生，促进他们的行为和发表原始调查的行为 完全保护临床服务。将提供免疫学调查中的具体指导，如 将指导科学写作，出版，道德和临床时间管理。

项目成果

Gene Therapy: Will the Promise of Optimizing Lung Allografts Become Reality?

• DOI: 10.3389/fimmu.2022.931524
• 发表时间: 2022
• 期刊: Frontiers in immunology
• 影响因子: 7.3

Complement-targeting therapeutics for ischemia-reperfusion injury in transplantation and the potential for ex vivo delivery.

• DOI: 10.3389/fimmu.2022.1000172
• 发表时间: 2022
• 期刊: Frontiers in immunology
• 影响因子: 7.3

Harnessing the B Cell Response in Kidney Transplantation - Current State and Future Directions.

• DOI: 10.3389/fimmu.2022.903068
• 发表时间: 2022
• 期刊: Frontiers in immunology
• 影响因子: 7.3

Complement-targeted therapies in kidney transplantation-insights from preclinical studies.

• DOI: 10.3389/fimmu.2022.984090
• 发表时间: 2022
• 期刊: FRONTIERS IN IMMUNOLOGY
• 影响因子: 7.3
• 作者: Anwar, Imran J.;DeLaura, Isabel;Ladowski, Joseph;Gao, Qimeng;Knechtle, Stuart J.;Kwun, Jean
• 通讯作者: Kwun, Jean