A Patient-Oriented Research Program in Geriatric Oncology

以患者为中心的老年肿瘤学研究项目

• 批准号: 10590987
• 负责人: Supriya G. Mohile
• 金额: $ 16.75万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10590987
• 关键词: Advanced Malignant Neoplasm; Advocate; Affect; Aging; American Society of Clinical Oncology; Award; Caregivers; Caring; Clinic; Clinical; Clinical Oncology; Clinical Trials; Cluster randomized trial; Communication; Communication Research; Community Clinical Oncology Program; Contracts; Data; Data Analyses; Data Set; Decision Making; Dose; Effectiveness; Elderly; Endowment; Exclusion; Fostering; Funding; Geriatric Assessment; Goals; Grant; Growth; Guidelines; Health; Health Status; High-Risk Cancer; Hospitalization; Intervention; Investigation; K-Series Research Career Programs; Knowledge; Lead; Leadership; Learning; Low Prevalence; Malignant Neoplasms; Manuscripts; Medicine; Mentors; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Modification; Oncologist; Oncology; Outcome; Outcomes Research; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Polypharmacy; Principal Investigator; Procedures; Prognosis; Publishing; Randomized; Recommendation; Relative Risks; Reporting; Research; Research Personnel; Resources; Risk; Scientist; Site; Symptoms; Testing; Time; Toxic effect; Training Support; Treatment Protocols; Treatment-related toxicity; United States National Institutes of Health; Universities; Woman; adverse outcome; cancer clinical trial; cancer therapy; career; career development; chemotherapy; clinical care; clinical practice; comorbidity; editorial; falls; functional improvement; health assessment; implementation evaluation; implementation science; implementation strategy; improved; improved outcome; interest; older patient; oncology program; patient oriented; patient oriented research; programs; provider factors; randomized, clinical trials; satisfaction; secondary analysis; skills; standard of care; success; treatment risk; uptake

PROJECT SUMMARY The principal investigator (PI), Dr. Supriya Mohile, of this K24 renewal proposal leads an independently funded patient-oriented geriatric oncology research program at the University of Rochester Wilmot Cancer Institute. Over the last K24 funding period, Dr. Mohile completed two large multi-site cluster-randomized trials that evaluated whether geriatric assessment and management (GAM) improves outcomes of older patients with advanced cancer. GAM, a validated patient-centered approach for assessing health status, identifies older patients with cancer who are at risk of adverse outcomes and guides management for cancer treatment and for aging-related conditions. Both trials demonstrated, for the first time, that a GAM intervention improves patient- centered outcomes (communication and patient/caregiver satisfaction) and clinical outcomes (treatment toxicity, falls, and polypharmacy). Integrally involved in this research, mentees at the University of Rochester and through the Cancer and Aging Research Group (CARG) have utilized data from the GAM trials to successfully compete for their own career development and independent awards. Of the ten early career scientists that Dr. Mohile currently mentors at the University of Rochester, eight are women and four identify as underrepresented in medicine. Mentees have received over 20 grants and have published over 80 manuscripts with Dr. Mohile. Dr. Mohile is currently a primary mentor or co-mentor on seven career development awards. Further, over the last K24 funding period, Dr. Mohile successfully competed for three new R-level awards as PI from the Patient Centered Outcomes Research and the National Institutes of Health to evaluate strategies for implementing GAM in oncology practices and to expand understanding about cancer treatment tolerability in older adults. The original K24 allowed Dr. Mohile and her mentees to enhance skills in communication research; the renewal will allow them to learn about implementation science and leadership with expert consultants at the University of Rochester and in CARG. The overarching aims of this proposal are: 1) to develop and evaluate implementation strategies for GAM in oncology practices; and 2) to examine treatment tolerability in older patients with advanced cancer and aging-related conditions starting a new high-risk cancer treatment regimen. This research will have a positive impact by providing information on pragmatic mechanisms for implementing GAM in oncology care. Importantly, this proposal will allow for the career development of mentees pursuing patient-oriented research focused on geriatric oncology, an understudied field. Through funded research, an endowment from the Wilmot Cancer Institute, and the NIA-funded CARG (MPI: Mohile), Dr. Mohile has the resources to continue to foster the careers of investigators interested in geriatric oncology research across the academic career trajectory. The renewal of this K24 Award will enable Dr. Mohile to expand mentoring to enhance the growth of patient-oriented research in geriatric oncology.

项目摘要 该K24更新提案的首席研究员（PI），Supriya Mohile博士领导了一个独立资助的 罗切斯特大学威尔莫特癌症研究所的面向患者的老年肿瘤学研究计划。 在最后一个K24资金期间，Mohile博士完成了两个大型多站点集群的试验，这些试验 评估老年评估和管理（GAM）是否改善了老年患者的结局 晚期癌症。 GAM是一种以患者为中心的评估健康状况的验证方法 癌症患者有不良后果的风险和指导癌症治疗和指导管理的患者 与衰老有关的条件。两项试验都首次表明，GAM干预改善了患者 - 集中的结果（沟通和患者/照顾者满意度）和临床结果（治疗 毒性，跌倒和多药）。罗切斯特大学的训练者在这项研究中始终参与 并通过癌症和衰老研究小组（CARG）利用了从GAM试验到 成功竞争自己的职业发展和独立奖项。十个早期职业 罗切斯特大学莫希尔（Mohile）目前指导的莫希尔（Mohile 医学的代表性不足。受训者已获得20多个赠款，并出版了80多个手稿 与Mohile博士。 Mohile博士目前是七个职业发展奖的主要导师或同事。 此外，在最后一个K24资金期间，Mohile博士成功地争夺了三个新的R级奖项，为PI 从以患者为中心的结果研究和美国国立卫生研究院来评估策略 在肿瘤学实践中实施GAM，并扩展对癌症治疗耐受性的理解 老年人。最初的K24允许Mohile博士和她的受训者提高交流技能 研究;续签将使他们能够与专家了解实施科学和领导 罗切斯特大学和卡格的顾问。该提议的总体目的是：1） 制定和评估GAM肿瘤学实践中的实施策略； 2）检查治疗 老年患者晚期癌症和与衰老有关的疾病的耐受性开始新的高危癌症 治疗方案。这项研究将通过提供有关务实的信息产生积极的影响 实施GAM在肿瘤护理中的机制。重要的是，该建议将允许职业 从事以老年肿瘤学为重点的以患者为导向的研究的受训者的发展，一项研究了 场地。通过资助的研究，威尔莫特癌症研究所的捐赠和NIA资助的Carg （MPI：Mohile），Mohile博士有资源继续培养对调查人员的职业 整个学术职业轨迹的老年肿瘤学研究。该K24奖的续订将启用 Mohile博士扩大指导，以增强老年肿瘤学中面向患者的研究的增长。