Neuropathology Core

神经病理学核心

基本信息

批准号：
10590704
负责人：
Julia K Kofler
金额：
$ 49.5万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-15 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10590704
关键词：
Access to Information Aging Algorithms Alzheimer disease prevention Alzheimer&apos s Disease Alzheimer&apos s disease patient Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Amyloid Area Autopsy Biological Markers Brain Classification Clinical Cognitive Collaborations Communities Consensus Data Databases Detection Diagnosis Diagnostic Disease Education Educational process of instructing Evaluation Family Feedback Fibroblasts Frontotemporal Lobar Degenerations Genetic Genetic Polymorphism Harvest Image Image Analysis Imaging technology Joints Knowledge Laboratories Liquid substance MRI Scans Measures Medical Students Mentors Microscopy Mission Molecular Nerve Degeneration Neurobiology Neurodegenerative Disorders Participant Pathologic Pathology Phenotype Positron-Emission Tomography Process Protocols documentation Psychoses Recommendation Recording of previous events Research Research Personnel Research Project Grants Resources Role Scanning Secure Slice Systems Analysis Technical Expertise Technology Time Tissue Banks Tissue Sample Tissues Triage United States National Institutes of Health Universities Update Variant Vascular Diseases alpha synuclein amyloid imaging brain tissue clinical diagnosis clinical phenotype cohort comorbidity computational pipelines data management data sharing diagnostic criteria digital digital imaging education research endophenotype histological image human tissue imaging agent imaging approach imaging biomarker imaging study improved in vivo instrumentation interest mild cognitive impairment neuroimaging neuroinflammation neuropathology novel personalized diagnostics protein TDP-43 psychiatric comorbidity repository research study resilience skills statistics tau Proteins therapeutic target tool treatment response web app whole slide imaging

项目摘要

Core D: Neuropathology Core. Summary/Abstract: The Neuropathology (NP) Core fulfills several important roles within the University of Pittsburgh ADRC (PITT-ADRC). Postmortem neuropathological confirmation of the clinical diagnosis of Alzheimer’s disease (AD) and related disorders and the assessment of co-existing neurodegenerative and vascular disease processes is essential to promote progress in diagnosis, treatment and prevention of AD. Since its inception, the NP Core has collected and characterized >739 brains from PITT-ADRC subjects at various disease stages. This resource has been extensively utilized for teaching purposes and for research studies by local and national investigators to develop amyloid PET imaging agents and correlate in vivo amyloid imaging results with postmortem findings, improve our understanding of genetic factors contributing to AD risk and advance our knowledge regarding the neurobiology of psychiatric comorbidities and neuroinflammatory processes. Our proposed approach to fulfill the diagnostic, tissue banking, research and educational roles of the NP Core is outlined in five specific aims: 1) The NP Core will continue to maintain and expand a well-catalogued bank of brain tissue samples and fibroblasts of ADRC participants and subjects from affiliated cohorts. A special emphasis will be placed on harvesting brains from subjects with premortem PiB and tau PET imaging studies. 2) All banked cases will undergo detailed diagnostic evaluation using the latest consensus criteria and detailed characterization of comorbid and aging-related pathologies. Results will be shared with ADRC clinical staff, families and uploaded to local and national databases (NACC). 3) The NP Core will provide neuropathological skills and expertise to researchers and will expand its efforts to utilize digital microscopy technologies and image analysis tools for identification and quantification of neurodegenerative pathologies. The generated pathology endophenotypes will be made available for association studies with genetic polymorphisms and clinical phenotypes such as the presence of psychiatric comorbidities, a major area of research at the PITT-ADRC. 4) The NP Core will continue to participate in local and national research efforts by providing brain bank tissue materials and neuropathology data from diagnostic evaluations. The NP core will closely collaborate with other PITT-ADRC cores and projects in joint research studies and will engage in NP Core-driven research projects. 5) In collaboration with the Research Education Component, the NP core will leverage brain bank materials and expertise to educate neuropathology fellows, residents, medical students and investigators about the neuropathologic features of neurodegenerative diseases. Through these aims, the NP core will provide precise diagnostic classifications of ADRC research participants, enable studies of phenotype variations and broadly support efforts to improve our understanding of the underlying disease processes.

核心D：神经病理学核心。摘要/摘要：神经病理学（NP）核心实现了几个匹兹堡ADRC（Pitt-ADRC）的重要角色。验尸神经病理学确认阿尔茨海默氏病（AD）和相关疾病的临床诊断以及评估共存神经退行性和血管疾病过程对于促进诊断进展至关重要，治疗和预防AD。自成立以来，NP核心已经收集并表征了> 739个大脑来自各种疾病阶段的Pitt-ADRC受试者。该资源已广泛用于教学目的和对地方和国家研究人员进行研究的研究并将体内淀粉样蛋白成像结果与事后发现相关联，提高我们对通用的理解导致AD风险并提高我们有关精神病神经生物学的知识的因素合并症和神经炎症过程。我们提出的履行NP诊断，组织银行，研究和教育作用的方法核心的五个特定目的概述：1）NP核心将继续维护和扩展良好的核心 ADRC参与者的脑组织样品和成纤维细胞和会员同胞的受试者。一个特别重点将放在带有Premortem Pib和Tau Pet成像的受试者的大脑上研究。 2）所有银行案件将使用最新的共识标准进行详细的诊断评估和合并症和与衰老有关的病理的详细表征。结果将与ADRC临床分享员工，家庭并上传到本地和国家数据库（NACC）。 3）NP核心将提供神经病理学技能和专业知识向研究人员，并将扩大其利用数字显微镜的努力用于识别和定量神经退行性病理的技术和图像分析工具。生成的病理内表型将用于与通用的关联研究多态性和临床表型，例如存在精神病合并症，这是一个主要领域 Pitt-Adrc的研究。 4）NP核心将继续参加本地和国家研究工作通过从诊断评估中提供脑库组织材料和神经病理学数据。 NP核心将与其他Pitt-ADRC核心和项目密切合作，并将参与 NP核心驱动的研究项目。 5）与研究教育部分合作，NP核心将利用脑库材料和专业知识来教育神经病理学研究员，居民，医疗学生和研究人员介绍了神经退行性疾病的神经病理学特征。通过这些目标，NP核心将提供ADRC研究的精确诊断分类参与者，启用对表型变化的研究，并广泛支持提高我们的理解的努力基础疾病过程。