Advancing a Bio-Psycho-Social Alcohol Treatment Research and Mentoring Program

推进生物心理社会酒精治疗研究和指导计划

• 批准号: 7950555
• 负责人: PETER M. MONTI
• 金额: $ 23.59万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950555
• 关键词: ARHGEF5 gene; Abstinence; Address; Admission activity; Adverse effects; Alcohol consumption; Alcohol dependence; Alcoholic beverage heavy drinker; Alcohols; Applications Grants; Area; Award; Behavioral Mechanisms; Benefits and Risks; Clinical; Communities; Complement; Consumption; Data; Data Set; Development; Disclosure; Dose; Early treatment; Environment; Epidemiologist; Equilibrium; Event; Faculty; Feedback; Funding; Gender; Genetic; Goals; Grant; HIV; Head; Hospitals; Individual; Individual Differences; Injury; Intervention; Intervention Studies; K-Series Research Career Programs; Laboratories; Laboratory Study; Learning; Left; Magnetic Resonance Imaging; Manuscripts; Measures; Mediating; Mediator of activation protein; Medical; Mentors; Mentorship; Modality; Motivation; National Institute on Alcohol Abuse and Alcoholism; Neurosciences; Outcome Assessment; Palm-Top Computers; Paper; Participant; Patient Self-Report; Patients; Pattern; Personal Digital Assistant; Pharmacological Treatment; Pharmacotherapy; Phase; Placebo Control; Placebos; Population; Positioning Attribute; Probability; Procedures; Psychologist; Public Health; Publications; Publishing; Qualifying; Randomized; Readiness; Records; Recruitment Activity; Reporting; Research; Research Design; Research Personnel; Risk; Sampling; Scientist; Self Efficacy; Senior Scientist Award; Severities; Site; Social support; Time; Titrations; Trauma; Treatment Efficacy; Treatment outcome; Universities; Visit; Wages; Woman; Work; Youth; abstracting; addiction; adolescent alcohol; alcohol abuse therapy; alcohol craving; alcohol effect; alcohol intervention; alcohol related problem; alcohol research; alcohol response; attenuation; base; behavioral/social science; biobehavior; biopsychosocial; brief intervention; career; contextual factors; cost; craving; cue reactivity; design; drinking; drinking behavior; experience; high risk; improved; interest; men; motivational enhancement therapy; problem drinker; professor; programs; public health relevance; reduced alcohol use; response; skills; social; standard care; topiramate; trauma centers; trauma units; treatment response; young adult

DESCRIPTION (provided by applicant): This is a new application for a Senior Research and Mentorship Award (K05). The candidate, Peter M. Monti, Distinguished Professor of Alcohol and Addiction Studies, Director, Center for Alcohol and Addiction Studies and Head of the Behavioral and Social Sciences Section at Brown University, proposes an initial period of intense research mentoring to four outstanding Brown University scientists in his Center and a shift in his research program to youth and young adults. Therefore, Dr. Monti proposes to transition from a VA Senior Career Scientist Award to the K05. Mentees and Mentoring Plan. One of the proposed mentees, Don Operario (a social psychologist) was recently recruited from Oxford University and is in a tenure-track position. The other two proposed faculty mentees, Robert Miranda (a clinical psychologist) and Tara White (a neuroscientist) are on a "research" track. While all three have excellent publication records, only Miranda has published alcohol papers and has received funding from NIAAA (a K23 and 2 R21s). Operario and White are NIDA-funded. None have been funded at the R01 level from NIAAA, though all three have demonstrated strong interest in becoming alcohol researchers. Miranda is furthest along, though both Operario and White have submitted alcohol applications as part of the candidate's pending P60 Center Grant Proposal. The fourth mentee, Margie Skeer (a social epidemiologist) is a postdoctoral candidate working with Monti. She too has a strong publication record. However, she has only just published her first alcohol manuscript, though she has indicated interest in alcohol, as this was her reason for coming to Brown. Mentoring goals for all applicants involve providing both targeted and general guidance and support for grantsmanship, the development of alcohol research programs, and more general professional development issues including feedback on how to mentor their own trainees. Importantly, all four mentees have been incorporated into the applicant's research program which is moving in the direction of youth alcohol intervention and the study of alcohol/HIV interactions. The applicant intends to gain complementary expertise in this area as well as in neuroscience and MRI modalities - all topics of his P60. With respect to the Research Plan, the applicant intends to continue to focus on a research agenda that is broad and yet focused on treatment mechanisms, pharmacotherapy, contextual factors and individual differences. Using his existing data sets he proposes to study mediators and moderators of treatment outcomes and the assessment of daily drinking behavior in the context of his brief intervention work. In addition he will add a study of lab-based alcohol effects onto his ongoing trial of topiramate for heavy drinkers, thus enabling the study of the effects of topiramate and drinking both in the lab (new data to be collected) and in the natural environment (through Ecological Momentary Assessment data that are already collected as part of his ongoing R01). Finally, as funding for his pending P60 application becomes clearer, he will begin pertinent pilot work on aspects of this project. PUBLIC HEALTH RELEVANCE: Advancing biopsychosocial approaches to alcohol treatment and mentoring has the potential to influence public health by reducing alcohol use in youth through improved early intervention and treatment. More and better mentored alcohol treatment scientists will facilitate the goal of reduced use in youth.

描述（由申请人提供）：这是高级研究和指导奖（K05）的新申请。候选人彼得·M·蒙蒂（Peter M. Monti）是布朗大学酒精与成瘾研究杰出教授、酒精与成瘾研究中心主任兼行为与社会科学部门负责人，他建议对布朗大学四所杰出的大学进行初期的密集研究指导他的中心的科学家以及他的研究计划转向青年和年轻人。因此，蒙蒂博士建议从 VA 高级职业科学家奖过渡到 K05。受训者和指导计划。唐·奥佩拉里奥（Don Operario，社会心理学家）是拟议的受训者之一，最近从牛津大学招聘，目前正处于终身教职职位。另外两名拟议的教员学员罗伯特·米兰达（临床心理学家）和塔拉·怀特（神经科学家）正在“研究”轨道上。虽然三人都有出色的发表记录，但只有米兰达发表过酒精论文并获得了 NIAAA 的资助（K23 和 2 R21）。 Operario 和 White 均由 NIDA 资助。尽管三人都表现出了成为酒精研究人员的浓厚兴趣，但没有人获得 NIAAA 的 R01 级别资助。米兰达走得最远，尽管 Operario 和 White 都提交了酒精申请，作为候选人待决的 P60 中心拨款提案的一部分。第四位学员玛吉·斯基尔（社会流行病学家）是与蒙蒂一起工作的博士后候选人。她也拥有良好的出版记录。然而，她刚刚发表了她的第一篇酒精手稿，尽管她已经表现出对酒精的兴趣，因为这是她来到布朗大学的原因。所有申请人的指导目标包括为资助、酒精研究项目的开发以及更一般的专业发展问题（包括如何指导自己的学员提供反馈）提供有针对性和一般性的指导和支持。重要的是，所有四名学员均已纳入申请人的研究计划，该计划正朝着青少年酒精干预和酒精/艾滋病毒相互作用研究的方向发展。申请人打算获得该领域以及神经科学和 MRI 模式的补充专业知识 - 他的 P60 的所有主题。关于研究计划，申请人打算继续关注广泛的研究议程，但重点关注治疗机制、药物治疗、背景因素和个体差异。他建议利用现有的数据集，在其简短的干预工作中研究治疗结果的中介因素和调节因素以及日常饮酒行为的评估。此外，他还将在他正在进行的托吡酯对重度饮酒者的试验中添加一项基于实验室的酒精影响的研究，从而能够在实验室（有待收集的新数据）和自然环境中研究托吡酯和饮酒的影响（通过生态瞬时评估数据，这些数据已作为他正在进行的 R01 的一部分收集）。最后，随着他待决的 P60 申请的资金变得更加明确，他将开始对该项目的各个方面进行相关的试点工作。 公共卫生相关性：推进酒精治疗和指导的生物心理社会方法有可能通过改善早期干预和治疗减少青少年饮酒，从而影响公共健康。更多更好的受指导的酒精治疗科学家将促进减少青少年饮酒的目标。