The Impact of Metals and Metal Mixtures on Cardiometabolic Disease Trajectories in Hispanics/Latinos

金属和金属混合物对西班牙裔/拉丁裔心血管代谢疾病轨迹的影响

• 批准号: 10617281
• 负责人: Margaret Schulz
• 金额: $ 5.27万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10617281
• 关键词: Address; Animals; Beta Cell; Biomedical Research; Biometry; Blood Pressure; Cardiometabolic Disease; Cardiovascular system; Cause of Death; Cell physiology; Cells; Chemicals; Clinical Medicine; Collaborations; Communities; Competence; Complement; Country; County; Data; Detection; Development; Diabetes Mellitus; Diastolic blood pressure; Disease; Education; Environmental Epidemiology; Environmental Exposure; Environmental Health; Exposure to; Fellowship; Fostering; Foundations; Future; Genetic Predisposition to Disease; Glycosylated hemoglobin A; Health; Heart Diseases; High Prevalence; Hispanic; Hispanic Populations; Hypertension; Impairment; Individual; Interdisciplinary Study; Intervention; Justice; Latino; Latino Population; Lead; Link; Measures; Mentorship; Metabolic; Metabolic Diseases; Metabolic dysfunction; Metabolism; Metal exposure; Metals; Methodology; Mexican Americans; Modeling; Myocardial Infarction; Not Hispanic or Latino; Nutrient; Outcome; Participant; Pathogenesis; Persons; Phenotype; Physicians; Play; Population; Population Study; Prevalence; Prevention strategy; Principal Component Analysis; Principal Investigator; Prospective cohort; Public Health; Publications; Pulse Pressure; Recording of previous events; Reduce health disparities; Regression Analysis; Regulation; Research Project Grants; Research Training; Risk; Risk Factors; Role; Scientist; Solid; Stroke; Techniques; Texas; Time; Toxic Environmental Substances; Training; Underrepresented Populations; United States; Vascular Diseases; blood glucose regulation; blood pressure elevation; cardiometabolic risk; cardiometabolism; cardiovascular risk factor; clinical training; cohort; community living; cost; diabetes risk; disease disparity; disorder prevention; disorder risk; empowerment; environmental justice; epidemiologic data; fasting plasma glucose; glycemic control; health disparity; high risk; high risk population; improved; insight; insulin sensitivity/resistance; lifestyle factors; lifetime risk; longitudinal analysis; modifiable risk; non-diabetic; prospective; skill acquisition; trait; urinary

Project Summary/Abstract Cardiometabolic diseases (CMDs), including diabetes and hypertension, impact two-thirds of people in the United States and are among the leading causes of death worldwide. CMDs lead to devastating consequences for those afflicated by them, such as the increased risk of vascular and heart disease, leading to future lethal complications such as myocardial infarction or stroke. Importantly, these conditions do not impact all individuals equally. CMDs are more prevalent in Hispanics/Latinos, and this population suffers worse complications and outcomes than non-Hispanic whites. While lifestyle factors and genetic predisposition play a role in CMD development, the potential contributions of environmental exposures has not been well-established. Starr County, Texas, is a predominantly Mexican-American community with staggering rages of CMDs, specifically diabetes mellitus. Interestingly, our preliminary data indicate that metal and metalloid exposures may increase the risk for CMDs and CMD-related traits in this population. Therefore, we hypothesize that exposure to metals/metalloids contributes to the observed heightened risk of CMDs in this population. To address this, we will leverage data from a well-established prospective cohort from Starr County, Texas, a community of >90% Hispanic/Latino origin. Utilizing already measured urinary metal/metalloid concentrations, we will evaluate longitudinal cardiovascular and metabolic trajectories of blood pressure, hemoglobin A1c, fasting plasma glucose, and homostatic measures of assessment for individual metal exposures and metal mixtures in 600 individuals over 3 years. Given the substantial individual and societal burden of CMDs, it is vital to identify modifiable risk factors in order to empower action for disease prevention, detection, and treatment. Through the project proposed in this application, valuable insight will be gained into the role of metal/metalloid exposures and CMD risk in a historically underrepresented population in biomedical research. Lastly, through this proposed research project and training plan, the applicant for this fellowship will receive comprehensive and complementary mentorship from a team of experts with a long history of collaboration, numerous opportunities for publication and presentation of scientific progress, and an overall outstanding education empowering her to become an independent principal investigator and physician-scientist devoted to improving environmental health and health justice.

项目摘要/摘要 心脏代谢疾病（CMD），包括糖尿病和高血压，影响三分之二的人 美国，是全球死亡的主要原因之一。 CMD导致毁灭性后果 对于那些被他们围困的人，例如增加血管和心脏病的风险，导致未来的致命 并发症，例如心肌梗塞或中风。重要的是，这些条件并不影响所有个人 同样。 CMD在西班牙裔/拉丁美洲人中更为普遍，并且该人口的并发症更严重，并且 结果比非西班牙裔白人。而生活方式因素和遗传倾向在CMD中起作用 发展，环境暴露的潜在贡献尚未得到良好的建立。斯塔尔 德克萨斯州县是一个主要是墨西哥裔美国人社区，CMD的愤怒，特别是 糖尿病。有趣的是，我们的初步数据表明金属和金属暴露可能会增加 该人群中CMD和CMD相关性状的风险。因此，我们假设接触 金属/金属剂会导致观察到的该人群中CMD的风险增加。为了解决这个问题，我们 将利用来自德克萨斯州斯塔尔县的公认的潜在队列的数据，一个> 90％的社区 西班牙裔/拉丁裔。利用已经测量的尿中金属/金属浓度，我们将评估 血压的纵向心血管和代谢轨迹，血红蛋白A1c，禁食等离子体 葡萄糖和600种单个金属暴露和金属混合物评估的均衡度量 个人超过3年。考虑到CMD的实质性和社会负担，必须确定 可修改的危险因素，以增强预防疾病，检测和治疗的能力。通过 在本应用程序中提出的项目，将获得有价值的见解，以获得金属/金属暴露的作用和 在历史上代表性不足的生物医学研究中，CMD风险。最后，通过这个建议 研究项目和培训计划，该奖学金的申请人将获得全面 拥有悠久合作历史的专家团队的补充指导，许多机会 为了发表和呈现科学进步，以及赋予她能力的整体杰出教育 成为独立的首席研究员和医师科学家，致力于改善环境健康 和健康正义。