MCSP TORFP NO. NIH-NINDS-21-01: FLORIO (ANAGIN) - BASE EC (STROKE)

MCSP TORFP 编号

基本信息

批准号：
10586013
负责人：
MELISSA ALLARD
金额：
$ 131.13万
依托单位：
ALBANY MOLECULAR RESEARCH, INC.
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-26 至 2023-09-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10586013
关键词：
Area Biological Assay Chemistry Computer Assisted Contractor Drug Compounding Enzymes Excretory function In Vitro Ischemic Stroke Logistics Metabolism National Institute of Neurological Disorders and Stroke Parents Performance Performance at work Pharmaceutical Chemistry Phase Services Shipping Stroke Structure-Activity Relationship Toxicology United States National Institutes of Health absorption base computational chemistry design drug discovery inhibitor novel novel therapeutics pre-clinical programs small molecule therapeutically effective

Area Biological Assay Chemistry Computer Assisted Contractor Drug Compounding Enzymes Excretory function In Vitro Ischemic Stroke Logistics Metabolism National Institute of Neurological Disorders and Stroke Parents Performance Performance at work Pharmaceutical Chemistry Phase Services Shipping Stroke Structure-Activity Relationship Toxicology United States National Institutes of Health absorption base computational chemistry design drug discovery inhibitor novel novel therapeutics pre-clinical programs small molecule therapeutically effective

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项目摘要

The Contractor, in performance of work under this task order shall provide a full-service facility and staff who would support a medicinal chemistry discovery program beginning at the Exploratory Chemistry phase to develop structure activity relationship (SAR) analysis and design, synthesis, in vitro absorption, distribution, metabolism, excretion and toxicology (ADMET), computational chemistry/Computer Aided Drug Discovery (CADD) and compound logistics of storage and shipping to support the Contributor Florio (Anagin) to develop a novel therapeutic effective in stroke. This will be achieved by advancing the SAR/SPR of their small molecule heterocyclic starting compound utilizing their assays and in vitro ADMET to identify novel, selective inhibitors of the target enzyme that are directed at ischemic stroke. The scope of this Medicinal Chemistry Support Program (MCSP) task order shall be medicinal chemistry services under Performance Area 2: Medicinal Chemistry Support in support of preclinical drug discovery efforts supported by NIH, NINDS and its Contributors (as outlined in the Parent SOW).

承包商，在此工作的表现任务订单应提供提供全方位服务的设施，并支持支持药物化学的工作人员从探索化学阶段开始的发现计划，以发展结构活动关系（SAR）分析和设计，合成，体外吸收，分布，代谢，排泄和毒理学（ADMET），计算化学/计算机辅助药物发现（CADD）和存储和运输的复合物流，以支持撰稿人弗洛里奥（Anagin）开发一种有效的中风的新型治疗性。这将通过前进来实现他们的小分子杂环的SAR/SPR利用其测定和体外ADMET鉴定针对靶酶的新型，选择性抑制剂缺血性中风。该药物化学支持计划（MCSP）任务订单的范围应为性能领域的药物化学服务2：药物化学支持为了支持NIH，Ninds及其贡献者支持的临床前药物发现工作（如父母概述）。