Estimating the Seroincidence of Melioidosis, Typhoid Fever and Scrub Typhus from Cross-sectional Serosurveys

从横断面血清调查中估计类鼻疽、伤寒和恙虫病的血清发病率

• 批准号: 10588900
• 负责人: Kristen Aiemjoy
• 金额: $ 18.03万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-21 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10588900
• 关键词: Acute; Address; Age; Antibodies; Antibody Response; Bayesian Modeling; Blood; Child; Clinical; Communicable Diseases; Complement; Complex; Coupled; Cross-Sectional Studies; Data; Data Set; Data Sources; Dependence; Development; Diagnosis; Diagnostic; Disease; Enrollment; Epidemiology; Etiology; Fever; Geography; Goals; Immunology; Incidence; India; Infection; Infectious Diseases Research; International; Intervention; Kinetics; Knowledge; Leadership; Longitudinal cohort; Machine Learning; Measures; Melioidosis; Mentored Research Scientist Development Award; Mentors; Mentorship; Methods; Modeling; Performance; Persons; Population; Prevention strategy; Province; Public Health; Recording of previous events; Reporting; Research; Research Priority; Research Support; Resources; Sampling; Schools; Scientist; Scrub Typhus; Selection Bias; Serology; Seroprevalences; Serum; Shapes; Symptoms; Thailand; Time; Training; Translating; Typhoid Fever; Undifferentiated; Universities; age related; analytical method; base; burden of illness; care seeking; computerized tools; design; evidence base; experience; global health; high dimensionality; innovation; international partnership; mathematical model; models and simulation; pathogen; population based; professor; programs; prospective; public health intervention; public health priorities; response; science teacher; seroconversion; serological marker; serosurvey; sex; simulation; skill acquisition; skills; tool; transmission process; treatment strategy

SUMMARY/ABSTRACT This mentored International Research Scientist Development Award (K01) from UC Davis and Mahidol University-Thailand will support Dr. Kristen Aiemjoy, Assistant Professor of Epidemiology, to establish an impactful, independent global health research program developing seroepidemiologic tools to measure and reduce the burden on infectious diseases globally. In Thailand, a priority research need is scalable tools to understand the population-level burden for etiologies of acute fever, with acute undifferentiated fever being the second-leading cause of care-seeking nationwide. To meet this need, the scope of this K01 is to evaluate innovative and pragmatic seroepidemiologic tools to characterize the population-level burden of three etiologies of acute undifferentiated fever: scrub typhus, melioidosis, and typhoid fever. The Specific Aims are Aim 1A) To model longitudinal antibody responses for scrub typhus and melioidosis and estimate peak antibody response, decay rate, and decay shape, and Aim 1B) To determine if antibody responses vary according to age; Aim 2) To develop an analytic approach for estimating the seroincidence of scrub typhus, melioidosis and typhoid fever from cross-sectional survey data; and Aim 3) To quantify the magnitude of selection bias induced by a school- based sample relative to a random population-based sample when estimating the incidence of scrub typhus, melioidosis, and typhoid fever. Data sources for the research strategy include existing longitudinal data from confirmed melioidosis, scrub typhus, and typhoid fever cases; high-dimensional simulated data; and prospective population-level serosurveys in Nong Khai province in Northeast Thailand. The research aims are paired with training goals designed to provide Dr. Aiemjoy with the skills and experiences necessary to build an independent global health research program. The specific training goals are to 1) acquire technical proficiency in the fundamental immunology of scrub typhus, enteric fever, melioidosis infections relevant for seroepidemiology; 2) establish expertise in innovative analytic approaches and computation tools for serologic data; and 3) cultivate the leadership, professional skills, and research partnerships necessary to become an independent global health research scientist. The training plan will be guided by a team of experienced mentors led by Dr. Narisara Chantratita (primary co-mentor, Mahidol University), a globally recognized leader in melioidosis immunology with over 30 years of clinical and laboratory infectious disease research in Thailand. Dr. Jason Andrews (primary co- mentor, Stanford University), a clinical scientist with expertise in statistical inference and mathematical modeling, will provide mentorship to evaluate diagnostics and interventions for tropical infectious diseases. The prolonged field experience and collaborative research supported by this IRSDA-K01, coupled with strong institutional support from UC Davis (Dr. Pollock, UCD Chair of Public Health Sciences and professional development mentor), will cultivate a sustained international research partnership with Dr. Aiemjoy and Mahidol University aimed at reducing the burden of infectious disease in Thailand and Globally.

摘要/摘要 该指导的国际研究科学家发展奖（K01）来自加州大学戴维斯分校和马希多 泰国大学将支持流行病学助理教授Kristen Aiemjoy博士，以建立 有影响力的独立全球卫生研究计划开发了血清ePIDEMIologic工具来衡量和 减轻全球传染病的负担。在泰国，优先研究需要是可扩展的工具 了解急性发烧病因的人口级负担，急性未分化的发烧是 全国范围内寻求照顾的第二大原因。为了满足这种需求，此K01的范围是评估 创新且务实的血清ePidemiologic工具来表征三种病因的人口级负担 急性未分化的发烧：磨砂鼠伤寒，黑梅利病和伤寒。具体目的是目标1a） 模型的纵向抗体反应，用于磨砂鼠伤寒和黑胶病，并估计峰值抗体反应， 衰减率和衰减形状，目标1B）确定抗体反应是否根据年龄变化；目标2） 开发一种分析方法来估计磨砂鼠伤寒，黑胶和伤寒的血清含量 来自横断面调查数据；目标3）量化学校引起的选择偏差的幅度 - 基于样本相对于基于群体的随机样本，估计磨砂鼠伤寒的发生率时， Melioidosis和伤寒。研究策略的数据源包括现有的纵向数据 确认的黑胶病，磨砂伤寒和伤寒病例。高维模拟数据；和潜在的 泰国东北部的北喀伊省的人口级血清武器。研究目的与 旨在为Aiemjoy博士提供建立独立所必需的技能和经验的培训目标 全球健康研究计划。具体培训目标是1）获得技术水平 灌木斑疹伤寒，肠发烧，黑胶病毒感染的基本免疫学； 2） 建立有关血清学数据创新分析方法和计算工具的专业知识； 3）种植 成为独立全球健康所需的领导，专业技能和研究伙伴关系 研究科学家。培训计划将由Narisara博士领导的经验丰富的导师团队指导 Chantratita（Mahidol University初级联合委员），全球公认的Melioidosis免疫学领导者， 在泰国进行了30年以上的临床和实验室传染病研究。 Jason Andrews博士（主要共同 斯坦福大学的导师），一名临床科学家，具有统计推断和数学建模方面的专业知识， 将提供指导，以评估热带传染病的诊断和干预措施。长时间 该IRSDA-K01支持的现场经验和协作研究，加上强大的机构 UC Davis的支持（UCD公共卫生科学与专业发展主席Pollock博士 导师），将与Aiemjoy博士和Mahidol大学建立持续的国际研究伙伴关系 旨在减轻泰国和全球传染病的负担。