Biomarkers of Early Experimental Glaucoma - Resubmission - 1

早期实验性青光眼的生物标志物 - 重新提交 - 1

基本信息

批准号：
10613439
负责人：
Gadi Wollstein
金额：
$ 71.08万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10613439
关键词：
3-Dimensional Acute Angiography Animal Model Animals Astrocytes Axon Axoplasmic Streaming Biological Markers Biomechanics Blindness Blood Vessels Brain Characteristics Chronic Clinical Treatment Complex Contrast Sensitivity Development Diagnosis Disease Early Diagnosis Electroretinography Ensure Event Experimental Designs Experimental Models Exposure to Eye Functional disorder Future Glaucoma Goals Health Health Transition Human Imaging technology In Situ Individual Individual Differences Intervention Intracranial Pressure Knowledge Life Location Macaca mulatta Measurement Mechanics Methods Modeling Monitor Morbidity - disease rate Nutritional Support Ocular Hypertension Optic Disk Optic Nerve Outcome Oxygen Consumption Papillary Pattern Perfusion Perimetry Physiologic Intraocular Pressure Predisposition Process Reporting Research Research Project Grants Retina Retinal Ganglion Cells Rhesus Risk Role Scanning Site Structure Testing Thick Three-dimensional analysis Time Tissues Translating Travel Visible Radiation Vision biomarker identification cell injury clinical care clinical diagnostics diagnostic tool early detection biomarkers follow-up image processing improved in vivo in vivo imaging insight new technology nonhuman primate ocular imaging optic nerve disorder preservation pressure response retinal damage spatial relationship timeline tissue oxygenation tool

项目摘要

PROJECT SUMMARY Glaucoma is a leading cause of vision morbidity and blindness with irreversible damage to retinal ganglion cells. Identifying biomarkers for early detection of glaucoma are paramount for timely initiation of treatment for preservation of functional vision throughout life. This project uses a chronic ocular hypertension animal model that provides unique insight into the changes the eye undergoes as it transitions from health to fully-manifest glaucoma. Using advanced ocular imaging technologies and state-of-the-art image processing methods we will monitor longitudinal structural and functional ocular changes, both global and local, of each animal as they develop glaucoma. We will determine the response of the optic nerve to two of the major causes of glaucoma – intraocular pressure (IOP) and intracranial pressure (ICP) – by acutely modulating these pressures and quantifying changes in optic nerve deformation at different time points along the course of the follow-up. This will allow determining the role of these pressures at the various stages of glaucoma development and changes in the optic nerve resulting from chronic exposure to elevated IOP, also known as remodeling. Lastly, we will identify structural and functional features and locations in the eye that are associated with future development of glaucomatous damage. The outcome of this project will provide insight into sensitive ocular biomarkers and their timeline of occurrence for early detection of glaucoma. Our model and tools ensure that the results can be translated to humans with substantial impact on clinical care.

项目概要青光眼是导致视力障碍和失明的主要原因，对视网膜神经节造成不可逆转的损害识别青光眼早期检测的生物标志物对于及时开始治疗至关重要。该项目使用慢性高眼压动物模型。提供对眼睛从健康过渡到完全显现时所经历的变化的独特见解使用先进的眼部成像技术和最先进的图像处理方法，我们将监测每只动物的纵向结构和功能性眼部变化，包括整体和局部我们将确定视神经对青光眼的两个主要原因的反应 - 眼内压 (IOP) 和颅内压 (ICP) – 通过急剧调节这些压力并量化随访过程中不同时间点视神经变形的变化。将有助于确定这些压力在青光眼发展和变化的各个阶段的作用长期暴露于升高的眼压而导致的视神经，也称为重塑。识别与未来发育相关的眼睛结构和功能特征以及位置青光眼损伤。该项目的成果将深入了解敏感的眼部生物标志物及其时间表我们的模型和工具确保可以将结果转化为早期检测青光眼的发生。对临床护理具有重大影响的人类。