Malawi Cancer Outcomes Research Program (M-CORP)

马拉维癌症结果研究计划 (M-CORP)

基本信息

批准号：
10613541
负责人：
Lameck Chinula
金额：
$ 26.83万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10613541
关键词：
AIDS Malignancy Consortium AIDS related cancer Acquired Immunodeficiency Syndrome Address Africa South of the Sahara African Cancer Burden Cancer Control Cervical Cancer Screening Cessation of life Clinical Trials Collaborations Country Databases Educational Curriculum Ensure Environment Epidemiology Foundations Funding Generations Grant HIV Human Development Institution International Leadership Lymphoma Malaria Malawi Malignant Neoplasms Malignant neoplasm of cervix uteri Malignant neoplasm of esophagus Medicine Mentors National Cancer Institute North Carolina Outcome Outcomes Research Postdoctoral Fellow Program Evaluation Research Research Personnel Research Priority Research Project Grants Testing Time Training Programs Tuberculosis USAID Universities anticancer research cancer clinical trial career clinical translation college experience improved indexing investigator training malignant breast neoplasm multidisciplinary programs skills success training opportunity

项目摘要

PROJECT SUMMARY Globally, there are more deaths from cancer than from HIV, tuberculosis, and malaria combined. In 2018, there were more than 18 million new cancer cases and 9.5 million cancer deaths worldwide, and, by 2030, these numbers will increase by at least 50%. Countries with low or medium Human Development Index account for more than 60% of cancer cases and 70% of cancer deaths. Cancer deaths in sub-Saharan Africa occur disproportionately from cancers that are preventable and/or curable including lymphoma, cervical cancer and breast cancer. Addressing the substantial burden of cancer requires a new generation of cancer researchers who can test hypotheses in the African context. The University of North Carolina Project- Malawi (UNCPM) has a rich cancer research environment that includes participation in the National Cancer Institute (NCI) U54 consortium for HIV associated malignancies, the AIDS Malignancy Consortium, the International Epidemiologic Databases to Evaluate AIDS (IeDEA), NCI African Esophageal Cancer Consortium, and a USAID-funded cervical cancer screening study. To date, UNCPM has had significant success in cancer clinical trials and translational research projects, and in establishing a handful of early- career investigators, but momentum is needed to build on this foundation. First, large improvements in cancer control in Malawi require approaches that extend beyond clinical trials to cancer outcomes research, a broader approach that requires unique skills. At this time, there are few cancer researchers with both the necessary cancer research skills and the local experience to develop cancer outcomes solutions adapted to the Malawian context. Second, there is no defined pipeline for early-career cancer research capacity. Finally, there are few opportunities for successful Malawian investigators to obtain the additional skills and experience necessary to be competitive for independent research funding. To address these gaps, we propose to establish the Malawi Cancer Outcomes Research Program (M-CORP). This application is led by UNC in conjunction with the University of Malawi College of Medicine (COM) and in collaboration with other national and international institutions and training programs. M-CORP aims to increase the cadre of trained investigators who can pursue independent research careers by: 1) establishing a robust curriculum and training opportunities across the continuum of cancer outcomes research specific to the Malawian environment and research priorities; 2) supporting advanced degrees; and 3) overcoming obstacles to research independence by providing post- doctoral opportunities including mentored pilot grants. We will use a multi-PD leadership strategy based at both UNC and UNCPM that will optimize our strengths across the spectrum of cancer outcomes research. An exceptional pool of multidisciplinary mentors, a detailed plan for program evaluation, and robust, broad-based partnerships between UNC and Malawian institutions ensure that M-CORP objectives will be met and will establish Malawi as an internationally recognized center of excellence for cancer outcomes research.

项目摘要在全球范围内，癌症的死亡人数多于HIV，结核病和疟疾的总和。在2018年全球超过1800万例新癌症病例和950万癌症死亡，到2030年，这些数字将至少增加50％。人类发展指数低或中等的国家占超过60％的癌症病例和70％的癌症死亡。撒哈拉以南非洲的癌症死亡发生不成比例地来自可预防和/或可治愈的癌症，包括淋巴瘤，宫颈癌和乳腺癌。解决癌症的重大负担需要新一代癌症可以在非洲背景下检验假设的研究人员。北卡罗来纳大学项目 - 马拉维（UNCPM）具有丰富的癌症研究环境，包括参与国家癌症研究所（NCI）U54艾滋病毒相关恶性肿瘤，艾滋病恶性财团，评估艾滋病的国际流行病学数据库（IEDEA），NCI非洲食管癌财团和美国国外资助的宫颈癌筛查研究。迄今为止，UNCPM有重要的癌症临床试验和转化研究项目的成功，并建立了一些早期职业调查人员，但需要势头才能建立在这个基础上。首先，癌症的大量改善马拉维的控制需要扩展到癌症结果研究的方法，这是更广泛的需要独特技能的方法。目前，癌症研究人员很少有必要癌症研究技能和当地的经验，以开发适合马拉维人的癌症结果解决方案语境。其次，没有针对早期癌症研究能力的定义管道。最后，很少成功的马拉维调查人员获得了获得所需的额外技能和经验的机会具有独立研究资金的竞争力。为了解决这些差距，我们建议建立马拉维癌症结果研究计划（M-CORP）。该应用程序由UNC与马拉维大学医学院（COM）并与其他国家和国际合作机构和培训计划。 M-CORP旨在增加可以追求的训练有素的调查人员的干部独立研究职业作者：1）在整个人中建立强大的课程和培训机会癌症结局的连续性研究特定于马拉维环境和研究重点； 2）支持高级学位； 3）克服研究独立的障碍，通过提供后包括指导的飞行员赠款在内的博士学位机会。我们将使用基于这两个的多PD领导策略 UNC和UNCPM将优化我们在癌症结果研究中的优势。一个多学科导师的特殊库，一个详细的计划评估计划，以及坚固的，基于广泛的计划 UNC与马拉维机构之间的伙伴关系确保将实现M-CORP目标并将将马拉维确立为国际公认的癌症结果研究卓越中心。