A Gesture-Powered Software Platform of Neurologic Music Therapy Games and Puzzles: To Stimulate Neuroplasticity and Prolong Functional Independence in Individuals Diagnosed with Alzheimer's Disease

神经音乐治疗游戏和谜题的手势驱动软件平台：刺激阿尔茨海默病患者的神经可塑性并延长功能独立性

• 批准号: 10611831
• 负责人: Peter Gray
• 金额: $ 50.45万
• 依托单位: OUTLIER TECHNOLOGY, LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10611831
• 关键词: Acceleration; Address; Aging; Algorithms; Alzheimer' s Disease; Alzheimer' s disease patient; Board Certification; Brain; Brain region; Catalogs; Cerebral hemisphere; Characteristics; Childhood; Cognition; Cognitive; Collaborations; Communication; Communities; Computer Vision Systems; Computer software; Curriculum Management System; Data; Data Analytics; Data Display; Development; Diagnosis; Disease; Disparate; Educational Curriculum; Elements; Emotional; Esthetics; Event; Evidence based intervention; Exhibits; Feasibility Studies; Feedback; Focus Groups; Gestures; Goals; Habilitation; Health; Human; Impaired cognition; Impairment; Improve Access; Individual; Institutional Review Boards; Intervention; Intuition; Learning; Life; Lighting; Machine Learning; Maps; Medical; Memory; Methods; Modality; Modeling; Modernization; Motion; Motor; Movement; Music; Music Therapy; Neurodegenerative Disorders; Neurologic; Neuronal Plasticity; Neurosciences; Nutrient; Outcome; Pathogenesis; Patient-Focused Outcomes; Patients; Pattern Recognition; Personal Satisfaction; Persons; Pharmaceutical Preparations; Phase; Phase II Clinical Trials; Play; Process; Rehabilitation therapy; Resources; Sampling; Senile Plaques; Social outcome; Source; Structure; System; Taste Perception; Technology; Therapeutic; Therapeutic Intervention; Time; Toxin; Training; Translating; Treatment Protocols; Validation; Variant; Well in self; algorithm training; brain repair; brain tissue; cerebral atrophy; computer science; data portal; deep learning; design; evidence base; executive function; experience; functional independence; haptic feedback; healing; improved; innovation; insight; instrument; musician; neural; neural circuit; neural network; neuropathology; next generation; novel; novel strategies; pain reduction; phase 2 designs; prototype; regression algorithm; repaired; structured data; success; symptom management; targeted treatment; tau aggregation; therapeutic candidate; trait; usability

Abstract The inclusion of music therapy into a total treatment modality can be used to improve the cognitive, physical, emotional, and social outcomes of patients diagnosed with neurological aging disorders, such as Alzheimer’s Disease (AD). Moreover, the healing benefits of music therapy and music-based interventions may be optimized when the patient is actively engaged in the process of creating music (composing, singing, moving), as opposed to sole reliance on receptive or passive music listening. The process of creating music has been shown to enhance neuroplasticity, reduce pain, and promote mental wellness. AD, in particular, as a neurodegenerative disease characterized by adverse neuropathological changes that impair neural connectivity and the brain’s natural ability to repair itself, is a prime candidate for the therapeutic neurological benefits that arise from creating music. Unfortunately, however, those who stand to gain the most from creating music often find the challenging process of relearning, learning, and/or manipulating a musical instrument to be impractical. Outlier Technology (Outlier) seeks to address this issue by developing a novel, Neurologic Music Therapy (NMT)-based software platform to help modernize the rehabilitation and habilitation of function & well-being among people suffering from AD. This next-generation approach to NMT will offer the medical community an innovative new way to enhance neuroplasticity and mitigate cognitive decline. The hallmark of this platform is a proprietary algorithm which utilizes computer vision as an input modality to translate body movements into an interactive, aesthetically pleasing musical experience integrated with a data-driven curriculum of NMT-based puzzles and games designed in collaboration with Board-Certified Music Therapists (MT-BCs) to target therapeutic objectives. This platform can be utilized by therapists to augment their traditional treatment regimens or by patients who do not have regular access to therapy resources but seek the potential benefits of such use. This proposal describes the development of a gesture-powered “smart instrument” that combines an interactive, adaptive, and therapeutic music creation experience with structured data analytics. Musical data from studio musicians will be sampled, analyzed, and mapped onto an aesthetically refined decision matrix that produces pleasing, software-generated music that may be customized to the user’s personal tastes. Computer vision will be used to map physical movements onto sensible musical outcomes to develop a “smart instrument” with intuitive, motion-powered haptic feedback. A curriculum of NMT-based games and puzzles that utilize this instrument will be developed with neuroscientists and MT-BCs to stimulate neuroplasticity and prolong functional independence. We will also integrate a data portal which allows the practitioner to record real-time patient events and notes about session progress, and access organized displays of data from each session which identify musical characteristics with strong associations to positive patient outcomes. The proposed development will yield a prototype demonstrating proof-of-concept for a groundbreaking new approach to AD rehabilitation.

抽象的 将音乐疗法纳入总治疗方式可以用于改善认知，身体， 诊断患有神经衰老疾病的患者的情绪和社会结果，例如阿尔茨海默氏症 疾病（AD）。此外，可能优化音乐疗法和基于音乐的干预措施的康复益处 当患者积极参与创作音乐的过程（作曲，唱歌，移动）时， 唯一依赖接受或被动音乐的聆听。创作音乐的过程已显示为 增强神经塑性，减轻疼痛并促进心理健康。特别是AD作为神经退行性 以不良神经病理学变化为特征的疾病会损害神经元连通性和大脑 自然修复的能力是创造治疗性神经系统益处的主要候选人 音乐。但是，不幸的是，那些从创作音乐中获得最大收益的人经常会发现挑战 学习，学习和/或操纵乐器的过程是不切实际的。 Outier Technology（Outier）试图通过开发一种新颖的神经音乐疗法来解决这个问题 （NMT）基于基于的软件平台，以帮助现代化功能与福祉的康复和居住 在患有广告的人中。 NMT的下一代方法将为医学界提供 创新的新方法来增强神经可塑性并减轻认知能力下降。这个平台的标志是 专有算法利用计算机视觉作为输入方式将身体运动转化为 与基于NMT的数据驱动的课程集成的互动性，美学上令人愉悦的音乐体验 与董事会认证的音乐治疗师（MT-BC）合作设计的难题和游戏 治疗目标。治疗师可以利用该平台来增强其传统治疗方案 或者没有定期获得治疗资源但寻求这种使用的潜在好处的患者。 该提案描述了一个手势驱动的“智能工具”的发展，该工具结合了一个 结构化数据分析，交互式，适应性和治疗性音乐创造体验。音乐数据来自 录音室音乐家将进行采样，分析和映射到美学精致的决策矩阵中 请生产可以根据用户个人品味定制的软件生成的音乐。电脑 视觉将用于将物理运动映射到敏感的音乐成果上，以开发“智能乐器” 具有直观的动力触觉反馈。利用这一点的基于NMT的游戏和难题的课程 仪器将使用神经科学家和MT-BC开发，以刺激神经塑性并延长功能 独立。我们还将集成一个数据门户，该门户允许从业者记录实时患者事件 以及有关会话进度的注释，以及每个会话的访问有组织的数据显示，以识别 音乐特征与积极的患者结局有很强的联系。拟议的发展将 产生一个原型，展示了一种开创性的广告康复方法的概念验证。