North Carolina Diabetes Research Center

北卡罗来纳州糖尿病研究中心

基本信息

批准号：
10609099
负责人：
Morgana Lee Mongraw-Chaffin
金额：
$ 18.4万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-07 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10609099
关键词：
Bioinformatics Biological Cells Clinical Clinical Management Complement Complex Computer Analysis DNA DNA Methylation DNA sequencing Data Data Analyses Development Diabetes Mellitus Disease Disease Progression Epigenetic Process Faculty Functional disorder Gene Expression Gene Expression Profile Genes Genetic Determinism Genetic Predisposition to Disease Genetic Transcription Genome Genomics Goals Health Sciences Individual Institution Knowledge Label Lipids Lipoproteins Mass Spectrum Analysis Metagenomics Mitochondria Molecular Molecular Profiling North Carolina Pathway Analysis Plasma Play Post-Translational Protein Processing Preparation Process Proteins Proteomics RNA Research Research Design Research Personnel Resources Risk Sampling Serum Services Small RNA Stable Isotope Labeling System Technology Time Tissues Universities Variant Work biological systems cost efficient data integration diabetes risk disorder risk epigenetic regulation epigenomics exosome experience forest individual patient instrumentation member metabolomics multiple omics next generation sequencing novel strategies particle precision medicine programs sample collection small molecule statistics tool transcriptome sequencing whole genome

项目摘要

PROJECT SUMMARY/ABSTRACT – GENOMICS AND PROTEOMICS CORE As part of the North Carolina Diabetes Research Center (NCDRC), the Genomics and Proteomics Core (GPC) will utilize state-of-the-art resources and expertise in genomics and mass spectrometry at the Wake Forest Center for Precision Medicine to provide unique access to high-throughput instrumentation and analytical expertise to NCDRC faculty and affiliate members in support of ongoing and future research programs. The GPC builds on the extensive long-standing expertise and experience of several investigators who have supported Core components for other large-scale research efforts in genomics, epigenomics, proteomics and bioinformatics and statistics, and who are all part of the Center for Precision Medicine at Wake Forest University Health Sciences. The GPC will also coordinate the use of existing genomics, epigenomics, and proteomics resources at the partner institutions (UNC, NC A&T, and Duke University), and coordinate work and data analysis with the Metabolomics Core to provide the entire suite of omics analyses. The NCDRC GPC will offer analytic services, but equally importantly, the GPC will provide the knowledge and tools to integrate the data to better understand the interactive systems at play in disease processes.

项目摘要/摘要 - 基因组学和蛋白质组学核心作为北卡罗来纳州糖尿病研究中心（NCDRC）的一部分，基因组学和蛋白质组学核心（GPC）将利用Wake Forest的基因组学和质谱法的最先进资源和专业知识精密医学中心，可提供对高通量仪器和分析的独特访问 NCDRC教师和会员的专业知识，以支持正在进行的和未来的研究计划。 GPC 建立在支持支持的几位调查人员的丰富长期专业知识和经验的基础上用于基因组学，表观基因组学，蛋白质组学和生物信息学的其他大规模研究工作的核心组成部分和统计数据，并且都是Wake Forest University Health的精密医学中心的一部分科学。 GPC还将协调现有基因组学，表观基因组学和蛋白质组学资源的使用在合作伙伴机构（UNC，NC A＆T和Duke University），并协调工作和数据分析代谢组学核心提供整个OMICS分析套件。 NCDRC GPC将提供分析服务，但同样重要的是，GPC将提供知识和工具以整合数据以更好地理解疾病过程中发挥作用的交互式系统。