3D Multi-Functional Catheter-Based Imaging of Coronary Lesion Composition, Structure, and Hemodynamics in Intermediate Stenoses

基于 3D 多功能导管的中间狭窄冠状动脉病变成分、结构和血流动力学成像

基本信息

批准号：
10608207
负责人：
Brooks D Lindsey
金额：
$ 62.47万
依托单位：
GEORGIA INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2025-03-31
项目状态：
未结题

项目摘要

PROJECT SUMMARY / ABSTRACT More than 1 million patients in the U.S. undergo cardiac catheterization each year, and more than 200k of these patients have stable coronary artery disease. Approximately 10% of patients with stable disease will experience a major adverse event within a given two year period. Current imaging approaches based on independent indicators have largely failed to predict adverse events, thus there are currently no techniques capable of determining which patients are likely to experience adverse events such as myocardial infarction (MI). The ability to make treatment decisions based on comprehensive, simultaneous measurements of the complete coronary environment—including biomechanics and hemodynamics—rather than independent indicators could improve outcomes and reduce costs in at-risk patients. This project proposes to develop a very small, forward-viewing ultrasound catheter capable of simultaneously interrogating the comprehensive 3D coronary environment in order to guide decisions in the cardiac catheterization lab. Specifically, the CoSHIS catheter (Composition, Structure, and Hemodynamics in Intermediate Stenoses) will simultaneously quantify the coronary environment (including plaque mechanics and blood flow) in real-time 3D, unlike current imaging approaches that seek to identify independent indicators of plaque rupture. In order to enable this multi- functional quantification to guide treatment decisions, technological development is needed to ensure accurate performance in a very small form factor. By leveraging recent advances in ultrasound imaging technology including array design, data reconstruction, high frame rate image formation, and internal flow catheters designed to minimize flow disturbance, this project will develop the core technology on for 4D mapping of the coronary mechanical enviornment This technology for imaging-guided intervention in the cardiac catheterization lab will unite expertise in ultrasound imaging and technology development, imaging-based computational modeling, animal models of coronary artery disease, and interventional cardiology, and will be developed according to the following three Aims: 1. Development of a forward-viewing system for 3D intravascular ultrasound (US) imaging of lesion morphology, hemodynamics, and plaque composition. 2. Validation of novel ultrasound measurement technology with established techniques including computed tomography (CT), computational fluid dynamics (CFD) based on angiography, and virtual histology intravascular ultrasound. 3. Evaluation of simultaneous US-based measurement in animal models of intermediate stenoses with validation using established techniques.

项目摘要 /摘要美国每年有超过100万患者接受心脏导管插入术，其中超过200k 患有稳定的冠状动脉疾病。大约10％的患有稳定疾病的患者会遭受重大不良在给定的两年内的事件。基于独立指标的当前成像方法在很大程度上未能预测不良事件，因此目前尚无能力确定哪些患者的技术体验不良事件，例如心肌梗塞（MI）。根据全面的，同时测量完整的冠状动脉环境 - 包括生物力学和血液动力学 - 比独立指标可以改善预后并降低处于危险患者的成本。这个项目提出的提议要开发一个非常小的，前视的超声导管，能够简单地询问全面的3D冠状动脉环境，以指导心脏导管插入术实验室的决策。具体而言，COSHIS导管（中间狭窄中的组成，结构和血液动力学）将类似地，在实时3D中量化冠状动脉环境（包括斑块力学和血流），与当前试图识别斑块破裂的独立指标的成像方法。为了启用这个多功能量化以指导治疗决策，需要技术发展以确保准确表现非常小。通过利用超声成像技术的最新进展，包括数组设计，数据重建，高帧速率图像形成和旨在最小化流量的内流动导管干扰，该项目将开发用于冠状动脉机械环境4D映射的核心技术这项用于成像引导干预心脏导管插入实验室的技术将在超声波上团结专业知识成像和技术开发，基于成像的计算建模，冠状动脉疾病的动物模型，和介入心脏病学，将根据以下三个目标开发： 1。开发用于3D血管内超声（US）病变形态成像的前视系统，血液动力学和斑块组成。 2。使用既定技术（包括计算机断层扫描）的新型超声测量技术的验证（CT），基于血管造影的计算流体动力学（CFD）和虚拟组织学内血管内超声。 3。评估中间stenose的动物模型中的简单基于美国的测量，并使用建立的技术。