Core C -Centralized Laboratory Support Core

核心C - 集中实验室支持核心

• 批准号: 10609765
• 负责人: Grace M Aldrovandi
• 金额: $ 19万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-08 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609765
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Bioinformatics; Biological Assay; Biological Markers; Blood; Blood Cells; CLIA certified; Clinical; Clinical Research; Communities; Computer Analysis; Consultations; DNA; Dedications; Diagnostic; Disease remission; Education; Enzyme-Linked Immunosorbent Assay; Funding; Genome; Genomics; Goals; Grant; HIV; HIV-1; HIV/AIDS; Human; Immune response; Immunoassay; Immunology; Immunology procedure; Infection; Interdisciplinary Study; Laboratories; Laboratory Study; Link; Los Angeles; Measurement; Mentors; Modeling; Mucous Membrane; Needs Assessment; Plasma; Proteome; Proteomics; Publications; RNA; Reporting; Research; Research Design; Research Personnel; Resources; Science; Scientist; Services; Shotguns; Specimen; Techniques; Technology; Tissues; Training; Training and Education; Umbilical Cord Blood; Viral Load result; Work; complex data; cost effective; cytokine; design; innovation; interest; lectures; metabolome; metabolomics; metagenomic sequencing; microbiome; microbiome sequencing; multidisciplinary; new technology; next generation sequencing; novel; programs; response; tool; virology

Core C: Project Summary/Abstract: A major focus of the UCLA-CDU Center for AIDS Research (CFAR) is facilitation of multidisciplinary science to advance research in HIV prevention, treatment, and ART-free remission. The Centralized Laboratory Support Core functions to provide investigators with a one-stop center for consultation and access to laboratory assays, cutting-edge technologies, and expertise to support innovative, multidisciplinary research. Laboratory services include assays focused on virology, immunology, and `omics' technologies including microbiome. In addition, this Core provides novel access to valuable human blood and mucosal specimens. These services enable timely and cost-effective access to these assays and tissues, which would be otherwise unattainable for many CFAR investigators. The Core will also work to develop new assays and research tools in response to the scientific interests of its users. The Core will also offer CAP/CLIA-certified laboratory services to support advancement of clinical research. Finally, the Core will also provide important training and education services to keep the CFAR community up to date on the latest technologies and specifically support early stage investigators in the transition to independence. Specifically, we propose to: 1) Facilitate basic and translational HIV/AIDS research through comprehensive laboratory services to assess HIV- 1 infection and immune responses; 2) Provide expertise in the design, implementation, and analysis of studies examining HIV-1 and the microbiome, metabolome, or proteome; 3) Support clinical research on HIV prevention, treatment, and ART-free remission through CAP/CLIA-certified laboratory services; and 4) Support and stimulate translational HIV/AIDS research by providing mentoring, training, and education programs in relevant laboratory techniques.

核心C：项目摘要/摘要：UCLA-CDU艾滋病研究中心（CFAR）的主要重点是 促进多学科科学的促进，以提高预防艾滋病毒，治疗和无艺术的研究 缓解。集中实验室支持核心功能，为调查人员提供一个一站式中心 咨询和获取实验室测定，尖端技术和专业知识以支持创新的专业知识， 多学科研究。实验室服务包括专注于病毒学，免疫学和“ OMICS”的测定法 包括微生物组在内的技术。此外，该核心为有价值的人类血液和 粘膜标本。这些服务使及时且具有成本效益的访问这些测定法和组织，这 对于许多CFAR调查人员来说，否则是无法实现的。核心也将努力开发新测定 和研究工具，以响应其用户的科学利益。核心还将提供CAP/CLIA认证 实验室服务以支持临床研究的进步。最后，核心也将提供重要的 培训和教育服务，以使CFAR社区有关最新技术和 特别支持早期研究人员过渡到独立性。具体来说，我们建议：1） 通过全面的实验室服务来促进基本和转化的艾滋病毒/艾滋病研究，以评估HIV- 1感染和免疫反应； 2）在研究，实施和分析方面提供专业知识 检查HIV-1和微生物组，代谢组或蛋白质组； 3）支持预防艾滋病毒的临床研究， 通过CAP/CLIA认证的实验室服务治疗和无艺术的缓解； 4）支持和刺激 转化艾滋病毒/艾滋病研究通过在相关实验室提供指导，培训和教育计划 技术。