2023 Mechanisms of Membrane Transport GRC & GRS

2023 GRC膜传输机制

基本信息

批准号：
10609187
负责人：
Janice L Robertson
金额：
$ 2.5万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-12-01 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10609187
关键词：
Academia Affect Allosteric Regulation Atomic Force Microscopy Awareness Brain Cell membrane Cells Cellular Membrane Communication Country Cryoelectron Microscopy Data Disease Ensure Environment Epilepsy Equity Europe Financial Support Fluorescence Microscopy Functional disorder Future Goals Hour Human body International Ion Channel Lead Lipid Bilayers Location Mass Spectrum Analysis Mediating Membrane Membrane Proteins Membrane Transport Proteins Mental disorders Mission Mutation National Institute of Neurological Disorders and Stroke Nerve Nerve Degeneration Pain Participant Pathologic Pathway interactions Physiological Physiology Postdoctoral Fellow Proteins Pump Regulation Research Research Personnel Role Running Science Scientist Senior Scientist Sex Bias Spottings Structure Students Techniques Time Training Transmembrane Transport Travel Underrepresented Populations United States National Institutes of Health Universities Woman Work addiction body system career cohort equity, diversity, and inclusion graduate student human disease insight macromolecular assembly meetings neurotransmission novel therapeutic intervention peer pharmacologic posters programs protein structure recruit sensory stimulus single molecule symposium

Academia Affect Allosteric Regulation Atomic Force Microscopy Awareness Brain Cell membrane Cells Cellular Membrane Communication Country Cryoelectron Microscopy Data Disease Ensure Environment Epilepsy Equity Europe Financial Support Fluorescence Microscopy Functional disorder Future Goals Hour Human body International Ion Channel Lead Lipid Bilayers Location Mass Spectrum Analysis Mediating Membrane Membrane Proteins Membrane Transport Proteins Mental disorders Mission Mutation National Institute of Neurological Disorders and Stroke Nerve Nerve Degeneration Pain Participant Pathologic Pathway interactions Physiological Physiology Postdoctoral Fellow Proteins Pump Regulation Research Research Personnel Role Running Science Scientist Senior Scientist Sex Bias Spottings Structure Students Techniques Time Training Transmembrane Transport Travel Underrepresented Populations United States National Institutes of Health Universities Woman Work addiction body system career cohort equity, diversity, and inclusion graduate student human disease insight macromolecular assembly meetings neurotransmission novel therapeutic intervention peer pharmacologic posters programs protein structure recruit sensory stimulus single molecule symposium

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项目摘要

Abstract: The Mechanisms of Membrane Transport GRC has been running since 1966. The mission of this GRC is to advance the understanding of ion channels, transporters and ATP driven pumps at the structural, mechanistic and physiological levels. Membrane transport is fundamental to the physiology of all cells. The dysfunction of membrane transport proteins, including ion channels, transporters and pumps, is associated with numerous diseases affecting every organ system in the human body. In particular, these proteins are of critical importance in the brain where they mediate all aspects of neurotransmission, and in nerves where they propagate sensory stimuli such as pain. Even subtle dysfunction of these proteins due to mutations, regulatory changes or pathological conditions leads to devastating human diseases such as epilepsy, neurodegeneration, and addiction and mental disorders. A fundamental understanding of the mechanisms of membrane transporters paves pathways towards developing novel therapeutic strategies and increasing their utility as pharmacological targets. The 2023 GRC, subtitled “Unraveling the Mechanisms of Membrane Transport: Structure, Dynamics and Allosteric Regulation” aims to generate vigorous discussions with a specific emphasis on exploring rigorous mechanistic studies of membrane transport proteins within the context of their physiologic environments and in view of their specific roles in cells. The GRC also aims to provide an effective forum for promoting early-career and under-represented scientists, facilitating them in achieving their career goals in science. A Gordon Research Seminar, organized by graduate students and post-doctoral fellows, will run together with the GRC during the preceding two days. The 2023 GRS will serve to promote scientific research by junior attendees and to further NIH training priorities through discussions of career options and strategies, and of gender biases in academia.

抽象的：膜运输GRC的机制自1966年以来一直在运行。该GRC的任务是在结构，机械和物理水平上提高对离子通道，转运蛋白和ATP驱动泵的理解。膜转运是所有细胞生理学的基础。膜转运蛋白的功能障碍，包括离子通道，转运蛋白和泵，与影响人体每个器官系统的许多疾病有关。特别是，这些蛋白质在大脑中介导神经传递的各个方面以及在传播感觉刺激（例如疼痛）的神经中至关重要。由于突变，调节性变化或病理状况引起的这些蛋白质的细微功能障碍也会导致毁灭性的人类疾病，例如癫痫，神经变性，成瘾和精神疾病。对膜转运蛋白机制的基本理解铺平了发展新型治疗策略并增加其作为药物靶标的效用的途径。 2023年的GRC副标题为“揭开膜运输的机制：结构，动力学和变构调节”旨在产生剧烈的讨论，并特别强调在其生理环境的背景下探索对膜转运蛋白的严格机械性研究，并在其细胞中的特定疾病中观察到。 GRC还旨在提供一个有效的论坛来促进早期职业和代表性不足的科学家，并支持他们实现科学领域的职业目标。由研究生和博士后研究员组织的戈登研究研讨会将在前两天与GRC一起运行。 2023年的GRS将通过讨论职业选择和策略以及学术界的性别偏见来促进初级参与者的科学研究，并进一步培训NIH培训优先级。