Core-001

核心001

• 批准号: 10609609
• 负责人: CHRISTIAN P LARSEN
• 金额: $ 35.71万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2023-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10609609
• 关键词: Address; Biological Assay; Cellular Immunology; Chronic; Clinical; Collaborations; Complex; Development; Elements; Flow Cytometry; Goals; Histopathology; Immune Tolerance; Immunity; Immunogenetics; Immunosuppression; Infection; Kidney Transplantation; Life; Maintenance; Molecular Immunology; Molecular Virology; Patient-Focused Outcomes; Procedures; Public Health; Research; Research Personnel; Services; Transplantation Tolerance; Virus; experimental study; improved; member; nonhuman primate

This U19 Consortium benefits from an integrated approach to performing non-human primate (NHP) transplant tolerance research. The hub of this integration is the Molecular and Cellular Immunology Core (MCIC), which coordinates and streamlines all common assays and procedures, as well as the NHP MHC typing needs for all members of this U19 collaborative group. The MCIC is comprised of five interacting elements: (1) The MHC Immunogenetics and Typing Core, (2) the Flow Cytometry Core, (3) the NHP Histopathology Core, (4) the Molecular Immunology and Virology Core, and (5) the Functional Protective Immunity Core. Each Core addresses a critical need for the conduct of the complex experiments that are proposed in each of the projects and promotes collaboration between investigators. As such, the development of these integrated services has significantly increased the efficiency and the rigor with which our group is able to execute complex NHP transplantation tolerance research.

该 U19 联盟受益于执行非人类灵长类动物 (NHP) 的综合方法 移植耐受研究。这种整合的核心是分子和细胞免疫学核心 (MCIC)，协调和简化所有常见的检测和程序，以及 NHP MHC U19 协作小组所有成员的打字需求。 MCIC 由五个相互作用的部分组成 要素：(1) MHC 免疫遗传学和分型核心，(2) 流式细胞术核心，(3) NHP 组织病理学核心，(4) 分子免疫学和病毒学核心，以及 (5) 功能保护 免疫核心。每个核心都满足进行复杂实验的关键需求 在每个项目中提出并促进研究人员之间的合作。因此， 这些综合服务的发展显着提高了效率和严谨性 我们小组能够进行复杂的NHP移植耐受性研究。