Core-001

核心001

• 批准号: 10609609
• 负责人: CHRISTIAN P LARSEN
• 金额: $ 35.71万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2023-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10609609
• 关键词: Address; Biological Assay; Cellular Immunology; Chronic; Clinical; Collaborations; Complex; Development; Elements; Flow Cytometry; Goals; Histopathology; Immune Tolerance; Immunity; Immunogenetics; Immunosuppression; Infection; Kidney Transplantation; Life; Maintenance; Molecular Immunology; Molecular Virology; Patient-Focused Outcomes; Procedures; Public Health; Research; Research Personnel; Services; Transplantation Tolerance; Virus; experimental study; improved; member; nonhuman primate

This U19 Consortium benefits from an integrated approach to performing non-human primate (NHP) transplant tolerance research. The hub of this integration is the Molecular and Cellular Immunology Core (MCIC), which coordinates and streamlines all common assays and procedures, as well as the NHP MHC typing needs for all members of this U19 collaborative group. The MCIC is comprised of five interacting elements: (1) The MHC Immunogenetics and Typing Core, (2) the Flow Cytometry Core, (3) the NHP Histopathology Core, (4) the Molecular Immunology and Virology Core, and (5) the Functional Protective Immunity Core. Each Core addresses a critical need for the conduct of the complex experiments that are proposed in each of the projects and promotes collaboration between investigators. As such, the development of these integrated services has significantly increased the efficiency and the rigor with which our group is able to execute complex NHP transplantation tolerance research.

该U19财团从进行非人类灵长类动物（NHP）的综合方法中受益 移植耐受性研究。该整合的枢纽是分子和细胞免疫学核心 （MCIC），它协调和简化所有常见的测定和程序以及NHP MHC 该U19协作小组的所有成员的打字需求。 MCIC由五个相互作用组成 元素：（1）MHC免疫遗传学和打字核心，（2）流式细胞仪核，（3）NHP 组织病理学核心，（4）分子免疫学和病毒学核心，以及（5）功能保护性 免疫力核心。每个核心都解决了对复杂实验的进行的关键需求 在每个项目中提出了提议，并促进了调查人员之间的合作。因此， 这些集成服务的开发显着提高了效率和严格性 我们的小组能够执行复杂的NHP移植耐受性研究。