2023 Cilia, Mucus and Mucociliary Interactions GRC & GRS

2023 纤毛、粘液和粘液纤毛相互作用 GRC

• 批准号: 10601200
• 负责人: BRIAN M BUTTON
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601200
• 关键词: Address; Adult; Area; Asthma; Automobile Driving; Biochemical; Biochemistry; Biological; Biological Models; Biology; Biomedical Engineering; Biophysics; COVID-19 pandemic; Cellular biology; Child; Chronic Bronchitis; Chronic Disease; Chronic Obstructive Pulmonary Disease; Cilia; Clinical; Collaborations; Cystic Fibrosis; Data; Development; Developmental Biology; Diagnosis; Diagnostic; Discipline; Disease; Education; Elements; Emerging Technologies; Environment; Epithelial Cells; Etiology; Faculty; Female; Fostering; Foundations; Functional disorder; Genetic; Genetic Diseases; Genetic Research; Genomics; Glycoproteins; Goals; Growth; Hair; Image; Infection; Inhalation; Italy; Knowledge; Leadership; Link; Lung diseases; Mechanics; Medicine; Mentors; Mentorship; Methods; Minority; Mission; Molecular; Mucins; Mucociliary Clearance; Mucous body substance; Oral; Participant; Pathologic; Physiology; Polymers; Postdoctoral Fellow; Primary Ciliary Dyskinesias; Production; Regulator Genes; Research; Research Personnel; Respiratory System; Respiratory Tract Diseases; Scientist; Senior Scientist; Structure; Surface; Talents; Technology; Translational Research; Underrepresented Minority; United States National Institutes of Health; Veins; Woman; Work; airway epithelium; burden of illness; career; cilium motility; empowerment; human disease; idiopathic pulmonary fibrosis; innovation; knowledge integration; lectures; meetings; minority scientist; molecular scale; multidisciplinary; multiple omics; nanoscale; novel; pathogen; posters; programs; public health relevance; research and development; respiratory health; stem; success; symposium; translational scientist

PROJECT SUMMARY This application seeks support for a Gordon Research Conference (GRC) and corresponding Gordon Research Seminar (GRS) on Cilia, Mucus and Mucociliary Interactions from February 18-24, 2023 in Barga, Italy. This is a highly integrated and unique meeting that unites basic scientists, bioengineers, translational investigators, and clinicians who study the components and fundamentals of cilia and mucus biology, their interface as a mucociliary apparatus, and human diseases related mucociliary dysfunction. Mucociliary clearance (MCC) is essential for respiratory tract defense against inhaled pathogens. MCC dysfunction leads to infections and to complications in asthma, rhinosinusitus, chronic obstructive lung disease (COPD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), and primary ciliary dyskinesia (PCD). Advancing technologies have led to growing knowledge of the assembly and function of cilia, the production and secretion of mucin glycoproteins, and the cilia-mucus interactions required for MCC. These innovations stem from the on-going work of established teams and new entrants, including young investigators. Thus, an important element of this meeting is promoting trainees and young investigators and involving women and minorities in alignment with missions of the GRC and the NIH. This GRS/GRC meeting will lay foundations and provide new ideas for current and emerging leaders in the mucociliary biology. A cohesive program is proposed to enhance the interplay between specialized disciplines that seek to integrate knowledge and impact advances in biochemistry, biophysics, cell biology, development, genetics, and translational research of common respiratory tract diseases. To enhance the educational strength of the meeting, trainees will be invited to participate in a GRS, to present oral summaries of their posters during morning lecture blocks, and in some cases give 10 min talks during the GRC meeting. The GRS and GRC leadership teams have the shared goal of fostering an innovative, informative, and integrated forum for discussing novel research and current challenges in mucociliary biology. The conference will emphasize the following scientific themes: a) genetic and gene regulatory mechanisms of mucociliary components, b) structure and function of mucin glycoprotein polymers and motile cilia, c) secretion of mucins and mechanics of ciliary activity, d) the effects of mucociliary function and dysfunction on host physiology and pathophysiology, and e) the on-going application of cilia and mucus biology to develop promote respiratory health and reduce the burden of disease. With this approach, we seek to achieve three Specific Aims: 1) To disseminate, discuss, and integrate the latest, unpublished, cutting-edge data on cilia, mucus and mucociliary interactions in a forum of world experts and early career scientists; 2) to provide a platform that links fundamental scientific knowledge related to cilia, mucus, and mucociliary interactions to human disease and avenues for diagnosis and therapies; and 3) to facilitate and promote the involvement and advancement of underrepresented minorities, women, and trainees in the study of cilia, mucus and mucociliary interactions.

项目摘要 该申请寻求支持戈登研究会议（GRC）和相应的戈登研究 从2023年2月18日至24日在意大利巴尔加的2月18日至24日开始，在纤毛，粘液和粘膜胶体相互作用上进行了研讨会（GRS）。这是 高度综合和独特的会议，将基础科学家，生物工程师，翻译调查员和 研究纤毛和粘液生物学的组成部分和基础的临床医生，它们的界面是 粘膜助剂和人类疾病相关的粘膜功能障碍。粘膜纤毛清除（MCC）为 对于防止吸入病原体的呼吸道防御必不可少的。 MCC功能障碍会导致感染和 哮喘的并发症，鼻鼻，慢性阻塞性肺疾病（COPD），特发性肺纤维化 （IPF），囊性纤维化（CF）和原发性睫状运动障碍（PCD）。发展技术导致了增长 了解纤毛的组装和功能，粘蛋白糖蛋白的产生和分泌以及 MCC所需的纤毛菌相互作用。这些创新源于已建立团队的持续工作 和新的参赛者，包括年轻的调查员。因此，这次会议的重要组成部分是促进 受训人员和年轻的调查人员，妇女和少数民族与GRC的任务保持一致 NIH。这次GRS/GRC会议将奠定基础，并为当前和新兴领导者提供新的想法 在粘膜生物学中。提出了一个有凝聚力的计划，以增强专业之间的相互作用 试图整合知识并影响生物化学，生物物理学，细胞生物学， 常见呼吸道疾病的发展，遗传学和翻译研究。增强 会议的教育力量，将邀请学员参加GRS，以介绍口头摘要 在早上的演讲街区的海报中，在某些情况下，在GRC会议上进行了10分钟的会谈。 GRS和GRC领导团队的共同目标是促进创新，内容丰富且综合的目标 讨论粘膜生物学新颖研究和当前挑战的论坛。会议将 强调以下科学主题：a）粘毛的遗传和基因调节机制 成分，b）粘蛋白糖蛋白聚合物和纤毛的结构和功能，c）粘蛋白分泌 和睫状活性的力学，d）粘膜功能和功能障碍对宿主生理学和功能障碍的影响 病理生理学以及e）纤毛和粘液生物学持续应用促进呼吸健康 并减轻疾病的负担。通过这种方法，我们试图实现三个具体目标：1） 传播，讨论和整合有关纤毛，粘液和粘膜纤毛的最新，未发表的尖端数据 在世界专家和早期职业科学家的论坛上进行互动； 2）提供一个链接基本的平台 与纤毛，粘液和与人类疾病的粘膜相互作用有关的科学知识以及 诊断和疗法； 3）促进和促进代表不足的参与和进步 在研究纤毛，粘液和粘膜互动的研究中，少数族裔，妇女和受训者。