Codevelopment of Sensory and Motor Function in Infants At Risk for Cerebral Palsy

有脑瘫风险的婴儿感觉和运动功能的共同发育

• 批准号: 10599885
• 负责人: Claudio Luis Ferre
• 金额: $ 21.02万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10599885
• 关键词: Acceleration; Affect; Age; Age Months; Animal Model; Area; Award; Behavior; Behavioral; Birth Place; Brain; Brain Diseases; Brain Injuries; Calibration; Career Choice; Cerebral Palsy; Child; Childhood; Clinical; Development; Development Plans; Developmental Disabilities; Disabled Children; Early Intervention; Evidence based treatment; Exhibits; Fiber; Foundations; Frequencies; Gestational Age; Goals; Growth; Imaging Techniques; Impairment; Infant; Intervention; Knowledge; Lateral; Life; Life Cycle Stages; Literature; Longitudinal Studies; Measurement; Measures; Mentorship; Mission; Modeling; Motor; Motor Activity; Motor Skills; Movement; Movement Disorders; Muscle Weakness; National Institute of Neurological Disorders and Stroke; Neonatal Brain Injury; Nervous System; Pathway interactions; Pattern; Perception; Positioning Attribute; Poverty; Pregnancy; Premature Birth; Premature Infant; Quality of life; Recovery; Research; Research Personnel; Risk; Sensorimotor functions; Sensory; Spinal Cord; Stretching; System; Teacher Professional Development; Time; Training; Unit of Measure; Uterus; Vulnerable Populations; career; career development; clinical diagnosis; design; disability; evidence base; expectation; experience; functional improvement; functional independence; functional near infrared spectroscopy; grasp; improved; insight; longitudinal analysis; motor behavior; motor control; motor impairment; motor recovery; nervous system disorder; neural; neurological rehabilitation; neurophysiology; novel; novel therapeutics; optical imaging; prenatal; prevent; programs; repaired; response; sensor; sensorimotor system; sensory system; social engagement; tool; trend

PROJECT SUMMARY Infants born prematurely (gestational age <32 weeks) are at risk (AR) for cerebral palsy (CP). CP is the most common pediatric movement disorder and is caused by damage to brain areas during development. Children with CP have motor and sensory impairments that cause muscle weakness, poor coordination, and difficulty grasping objects. These impairments prevent functional independence and reduce social participation. How these impairments arise throughout the course of life is not well understood. This is due in part to a limited understanding of how sensory and motor systems interact during development to organize brain circuits. The gap in knowledge is particularly problematic because the timing of motor and sensory brain area establishment (i.e. during the first year of life) coincides with a period in which the brain is highly plastic. Interventions for infants with CP are emerging, but little is known about the neural systems that can be targeted to optimize these novel interventions. We will longitudinally track infant movements and sensory function in relation to brain development in typically developing infants and infants AR for CP. By characterizing the development of sensorimotor function and brain activation patterns, we will identify key mechanisms of motor recovery. Understanding mechanisms of motor and sensory development during this age could provide potential targets for activity-dependent interventions at a time when the nervous systems is highly malleable. Thus, this project will provide novel insights aligned with the NINDS mission of advancing fundamental knowledge about the brain to improve treatments for neurological disease. My long-term goal is to develop a program of research that uses mechanistic information to develop evidence-based therapies that improve function in infants with CP. To accomplish this goal, I have developed a rigorous career development plan under the mentorship of an interdisciplinary team of researchers with expertise in content areas directly related to my training goals. My career development activities will focus on: 1) obtaining pragmatic professional development experiences to accelerate my career path, 2) developing expertise in integrated measurements of sensorimotor behavior and brain activity in infants, and 3) acquiring a strong foundation in clinical design and quantitative analyses for longitudinal studies. This training will position me to establish an active and rigorous research program that will advance knowledge and reduce the burden of pediatric brain disorders.

项目摘要 过早出生的婴儿（胎龄<32周）的脑瘫（CP）处于危险之中（AR）。 CP是最大的 常见的小儿运动障碍，是由发育过程中大脑区域损害造成的。孩子们 CP具有运动和感觉障碍，会导致肌肉无力，协调不佳和难度 抓住对象。这些障碍阻止了功能独立性并减少社会参与。如何 这些障碍在整个生命过程中都尚不清楚。这部分是由于有限的 了解感觉和运动系统在开发过程中如何相互作用以组织脑电路。这 知识差距尤其有问题，因为电动机和感觉脑区域建立的时机 （即，在生命的第一年）与大脑高度塑性的时期相吻合。干预措施 患有CP的婴儿正在出现，但对可以针对优化的神经系统知之甚少 这些新颖的干预措施。我们将纵向跟踪婴儿的运动和感官功能 CP的典型发育中的婴儿和婴儿AR的大脑发育。通过表征发展 感觉运动功能和大脑激活模式，我们将确定运动恢复的关键机制。 了解这个年龄段的运动和感觉发展的机制可以提供潜在的目标 对于在神经系统高度延展的时候，对于活动依赖性干预措施。因此，这个项目 将提供与Ninds的使命一致的新颖见解，该使命是推进有关 大脑改善神经疾病的治疗方法。我的长期目标是制定研究计划 使用机械信息来开发基于证据的疗法，以改善婴儿的功能 CP。为了实现这一目标，我已经制定了一项严格的职业发展计划 跨学科的研究人员团队在内容领域具有专业知识的研究人员与我的培训目标直接相关。我的 职业发展活动将重点关注：1）获得务实的专业发展经验 加速我的职业道路，2）在感觉运动行为的综合测量和 婴儿的大脑活动，3）在临床设计和定量分析方面获得强大的基础 纵向研究。这项培训将使我建立一个积极而严格的研究计划 提高知识并减轻小儿脑疾病的负担。