Intention Treatment for Anomia: Investigating Dose Frequency Effects and Predictors ofTreatment Response to Improve Efficacy and Clinical Translation

失智症的意向治疗：研究剂量频率效应和治疗反应的预测因素，以提高疗效和临床转化

• 批准号: 10597989
• 负责人: Amy D Rodriguez
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10597989
• 关键词: Address; Adjuvant; Age; Anomia; Aphasia; Behavior; Behavior assessment; Brain; Brain region; Chronic; Chronic Disease; Clinical; Cognitive; Computers; Data; Development; Dose; Family; Frequencies; Gestures; Goals; Hand; Health Care Costs; Healthcare Systems; Hospitalization; Image; Impairment; Individual; Intention; Intervention; Knowledge; Language; Learning; Left; Lesion; Location; Maintenance; Memory; Neurologic; Neurophysiology - biologic function; Outcome; Participant; Patients; Prediction of Response to Therapy; Quality of life; Research; Resources; Retrieval; Schedule; Service delivery model; Societies; Stroke; Time; Training; Treatment Factor; Treatment outcome; Veterans; Word Processing; Work; aphasia rehabilitation; clinical decision-making; clinical practice; clinical translation; cognitive function; cost; experience; follow-up; health related quality of life; image processing; improved; language impairment; military veteran; neural; neuroimaging; novel; optimal treatments; predicting response; response; stroke-induced aphasia; telehealth; therapy design; treatment group; treatment response; trial comparing; verbal

Difficulty retrieving words is one of the most common language complaints in individuals with stroke- induced aphasia. The negative consequences related to word retrieval impairment include increased health care costs and decreased quality of life. A variety of treatment approaches exist to improve word retrieval, and most of the treatments result in immediate improvement on trained words. However, long-term improvement and improvement on untrained words or behaviors is less common. Additionally, we currently know very little about optimal treatment administration parameters and we know even less about predictors of treatment response. Our current healthcare system is not resourced to provide ongoing treatment for individuals with chronic aphasia. To make the best use of the clinical resources available for aphasia treatment, and to maximize outcomes for Veterans with aphasia, we must: 1) develop clinically translatable treatments that yield widespread and lasting effects and 2) develop clinically accessible ways of identifying who will acquire benefit from a specific treatment approach. The proposed study in this Merit Review Application takes on these two challenges by investigating dose frequency (massed vs. distributed practice) effects and identifying the language, cognitive and neural predictors of response to Intention treatment (INT), a novel word retrieval treatment. Our preliminary studies provide strong support for the proposed study, which we expect will increase the efficacy, clinical translatability, and potential for use of INT as an adjuvant to other word retrieval treatments. From a broader perspective, our results will help guide selection of the right treatment for the right Veteran. This work has direct implications for clinical practice in aphasia rehabilitation and has the potential to make a significant positive impact on the VA Healthcare System and on Veterans living with aphasia.

单词检索困难是中风患者最常见的语言抱怨之一 诱发失语症。与单词检索障碍相关的负面后果包括健康状况恶化 护理费用和生活质量下降。存在多种处理方法来改善单词检索，并且 大多数治疗都会立即改善受过训练的单词。但长期改善 而未经训练的言语或行为的改善则不太常见。此外，我们目前所知甚少 关于最佳治疗管理参数，我们对治疗的预测因素知之甚少 回复。我们当前的医疗保健系统没有资源为患有此病的个人提供持续的治疗 慢性失语症。充分利用可用于失语症治疗的临床资源，并 为了最大限度地提高失语症退伍军人的治疗效果，我们必须：1）开发可临床转化的治疗方法 广泛和持久的影响，2) 开发临床上可行的方法来确定谁将受益 从具体的治疗方法来看。本优点审查申请中拟议的研究涉及这两项 通过调查剂量频率（集中与分布式实践）的影响并确定挑战 意图治疗（INT）反应的语言、认知和神经预测因子，一种新颖的单词检索 治疗。我们的初步研究为拟议的研究提供了强有力的支持，我们预计该研究将 提高 INT 的功效、临床可翻译性以及作为其他单词检索辅助手段的潜力 治疗。从更广泛的角度来看，我们的结果将有助于指导针对正确的患者选择正确的治疗方法 老将。这项工作对失语症康复的临床实践具有直接影响，并有可能 对退伍军人管理局医疗保健系统和患有失语症的退伍军人产生重大积极影响。