TRANSFER Neural Underpinnings of Emotion Regulation and Drinking to Cope among Problem Alcohol Drinkers

转移情绪调节和饮酒的神经基础以应对有问题的饮酒者

• 批准号: 10594117
• 负责人: Pilar M Sanjuan
• 金额: $ 10.72万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10594117
• 关键词: Alcohol abuse; Alcohol consumption; Alcohols; Amygdaloid structure; Anterior; Area; Arousal; Bioethics; Brain; Chiroptera; Clinical; Cognitive Science; Collection; Computer software; Coping Skills; Coupled; Cues; Data; Data Analyses; Data Set; Development; Development Plans; Dissociation; Distress; Dorsal; Ecological momentary assessment; Educational workshop; Emotional; Emotions; Evaluation; Expressed Emotion; Failure; Feeling; Functional Magnetic Resonance Imaging; Funding; Grant; Hippocampus (Brain); Incidence; Individual; Insula of Reil; Intervention; Judgment; Knowledge; Laboratories; Laboratory Study; Lateral; Life; Light; Link; Literature; Maintenance; Measurement; Measures; Medial; Memory; Mental disorders; Mentors; Methods; Neurons; Neurosciences; Patients; Peripheral Nervous System; Persons; Prefrontal Cortex; Process; Psychologist; Psychophysiology; Regulation; Research; Research Methodology; Sampling; Self Assessment; Signal Transduction; Stimulus; Stress; Stressful Event; Structure; Technology Assessment; Time; Training; Training Programs; Treatment outcome; Ventral Striatum; Writing; alcohol craving; alcohol misuse; alcohol research; alcohol use disorder; base; biological adaptation to stress; career development; cognitive neuroscience; craving; design; drinking; emotion regulation; emotional reaction; experience; human subject protection; improved; investigator training; meetings; negative affect; negative emotional state; negative mood; neural network; neuroimaging; neuromechanism; patient oriented research; problem drinker; programs; public health relevance; relating to nervous system; response; secondary analysis; social; symposium

Project Summary/Abstract This Mentored Patient-Oriented Research Career Development application (K23) will provide protected time for Dr. Pilar Sanjuan to develop a focused program of experimental alcohol research and its application to the study of neural mechanisms of emotion regulation underlying alcohol problems. The aims of the 5-year career development plan are tightly integrated and will increase her knowledge and experience in the areas of 1) collecting and analyzing objective neural (fMRI) and psychophysiological emotion regulation data, 2) utilizing advanced quantitative analysis and ecological momentary assessment (EMA) technology for real-time collection of longitudinal data in the field, and 3) grant writing and professional development. The career development plan includes structured meetings with mentors; five graduate level courses in neuroscience, cognitive psychology, and bioethics; and relevant conferences and workshops to develop substantive expertise and training in quantitative/research methods and uses of statistical software. Specific plans are described to consolidate knowledge gains associated with the career development aims through secondary analyses of extant fMRI and EMA data sets. These activities will culminate in the development of an R01 proposal using preliminary data from the associated study in the third and fourth years of the funding period, thus facilitating the transition of Dr. Sanjuan from clinical psychologist to independent neuroscientist. The proposed study will have 3 components and is sequenced to support career development aims: (1) a laboratory-based design to identify emotion regulation and craving neural networks associated with subjective distress and psychophysiological reactivity during emotion regulation in problem drinkers, (2) a field-based design using EMA to determine the relationship of problem drinking with subjective distress, alcohol craving, and drinking to cope, and (3) a lab-to-field analysis to assess the efficacy of laboratory-based neural activation to predict real life craving and drinking to cope measured via EMA. fMRI and psychophysiological assessments will be used to examine neural underpinnings of emotion regulation and EMA methods will be used to examine the real life emotion regulation to drinking to cope relationship. Dr. Eric Claus will be primary mentor and has recognized expertise in cognitive neuroscience, especially alcohol-related neuroimaging. Drs. J. Scott Tonigan and James Gross will serve as secondary mentors supporting the candidate in selected areas including laboratory study of emotion regulation, grant writing, human subjects protections, and data analysis. Drs. Marsha Bates and Matthew Pearson will serve as consultants to assist Dr. Sanjuan to consolidate knowledge gains in applying psychophysiology and EMA methods and analyses in the context of alcohol research.

项目摘要/摘要 这项受到指导的以患者为导向的研究职业发展应用程序（K23）将为受保护的时间 Pilar Sanjuan博士开发了一项重点的实验性酒精研究计划及其在 研究酒精问题的情绪调节的神经机制。 5年职业的目标 发展计划紧密整合，将在1的领域增加她的知识和经验） 收集和分析客观神经（fMRI）和心理生理情绪调节数据，2）利用 实时的高级定量分析和生态瞬时评估（EMA）技术 在现场收集纵向数据，以及3）授予写作和专业发展。职业 发展计划包括与导师的结构性会议；神经科学的五个研究生级课程， 认知心理学和生物伦理学；以及相关的会议和研讨会，以发展实质性专业知识 以及定量/研究方法的培训和统计软件的使用。特定计划被描述为 通过对职业发展相关的知识收益的旨在通过二次分析的旨在 现有的fMRI和EMA数据集。这些活动将在使用R01提案的开发中最终使用 相关研究的初步数据在资金期的第三年和第四年，从而促进 Sanjuan博士从临床心理学家转变为独立的神经科学家。拟议的研究将 有3个组件，并进行了测序以支持职业发展目的：（1）一种基于实验室的设计 确定情绪调节并渴望与主观困扰相关的神经网络 问题饮酒者的情绪调节期间的心理生理反应性，（2）一种基于现场的设计 EMA确定问题饮酒与主观困扰，渴望和饮酒的关系 COPE和（3）实验室到现场分析，以评估基于实验室的神经激活的功效以预测实际 通过EMA测量的生活渴望和饮酒。 FMRI和心理生理评估将被使用 检查情绪调节和EMA方法的神经基础将用于检查现实生活 饮酒的情绪调节。埃里克·克劳斯（Eric Claus）博士将成为主要导师，并已认可 认知神经科学，尤其是与酒精相关的神经影像学方面的专业知识。博士。 J. Scott Tonigan和James 总体将担任辅助导师，支持选定领域的候选人，包括 情绪调节，赠款写作，人类受试者的保护和数据分析。博士。玛莎·贝茨（Marsha Bates）和 Matthew Pearson将担任顾问，以协助Sanjuan博士巩固知识收益申请 在酒精研究的背景下，心理生理学和EMA方法和分析。

项目成果

Medication for Opioid Use Disorder During Pregnancy - Maternal and Infant Network to Understand Outcomes Associated with Use of Medication for Opioid Use Disorder During Pregnancy (MAT-LINK), 2014-2021.

• DOI: 10.15585/mmwr.ss7203a1
• 发表时间: 2023-05-05
• 期刊: MMWR SURVEILLANCE SUMMARIES
• 影响因子: 24.9
• 作者: Miele, Kathryn;Kim, Shin Y;Jones, Rachelle;Rembert, Juneka H;Wachman, Elisha M;Shrestha, Hira;Henninger, Michelle L;Kimes, Teresa M;Schneider, Patrick D;Sivaloganathan, Vaseekaran;Sward, Katherine A;Deshmukh, Vikrant G;Sanjuan, Pilar M;Maxwell, Jessie R;Seligman, Neil S;Caveglia, Sarah;Louis, Judette M;Wright, Tanner;Bennett, Carolyne Cody;Green, Caitlin;George, Nisha;Gosdin, Lucas;Tran, Emmy L;Meaney-Delman, Dana;Gilboa, Suzanne M
• 通讯作者: Gilboa, Suzanne M

Abnormal target detection and novelty processing neural response in posttraumatic stress disorder.

• DOI: 10.1016/j.pnpbp.2018.04.003
• 发表时间: 2018-07-13
• 期刊: Progress in neuro-psychopharmacology & biological psychiatry
• 影响因子: 5.6
• 作者: Sanjuan PM;Andrews C;Claus ED
• 通讯作者: Claus ED

Prenatal maternal posttraumatic stress disorder as a risk factor for adverse birth weight and gestational age outcomes: A systematic review and meta-analysis.

• DOI: 10.1016/j.jad.2021.08.079
• 发表时间: 2021-12-01
• 期刊: JOURNAL OF AFFECTIVE DISORDERS
• 影响因子: 6.6
• 作者: Sanjuan, Pilar M.;Fokas, Kathryn;Tonigan, J. Scott;Henry, Melissa C.;Christian, Korinna;Rodriguez, Andrea;Larsen, Jessica;Yonke, Nicole;Leeman, Lawrence
• 通讯作者: Leeman, Lawrence

Alcohol and other substance use disorder recovery during pregnancy among patients with posttraumatic stress disorder symptoms: A qualitative study.

• DOI: 10.1016/j.dadr.2021.100013
• 发表时间: 2021-12
• 期刊: Drug and alcohol dependence reports
• 作者: Henry MC;Sanjuan PM;Stone LC;Cairo GF;Lohr-Valdez A;Leeman LM
• 通讯作者: Leeman LM

Best Practices for Engaging Pregnant and Postpartum Women at Risk of Substance Use in Longitudinal Research Studies: a Qualitative Examination of Participant Preferences.

• DOI: 10.1007/s42844-020-00019-1
• 发表时间: 2020
• 期刊: Adversity and resilience science
• 作者: Beasley LO;Ciciolla L;Jespersen JE;Chiaf AL;Schmidt M;Shreffler KM;Breslin FJ;Bakhireva LN;Sanjuan PM;Stephen JM;Coles CD;Chambers CD;Kable JA;Leeman L;Singer LT;Zellner J;Morris AS;Croff JM
• 通讯作者: Croff JM