Duke/UNC Alzheimer's Disease Research Center

杜克大学/北卡罗来纳大学阿尔茨海默病研究中心

• 批准号: 10263683
• 负责人: GWENN A GARDEN
• 金额: $ 312.8万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263683
• 关键词: Advocacy; Affect; Age; Age-associated memory impairment; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Award; Back; Bioinformatics; Biological; Biological Aging; Biological Markers; Biological Models; Biology of Aging; Biomedical Research; Brain; Caliber; Cardiovascular Diseases; Caregivers; Catchment Area; Clinical; Collaborations; Collection; Communication; Communities; Community Outreach; Complex; Coupled; Data; Data Analyses; Data Management Resources; Data Set; Data Store; Dementia; Development; Disease; Doctor of Philosophy; Down Syndrome; Education; Elderly; Elements; Enrollment; Environment; Event; Faculty; Family Caregiver; Fostering; Funding; Future; Gardenal; Generations; Geroscience; Goals; Health; Health Services; Heritability; Image; Impairment; Individual; Inflammation; Information Dissemination; Infrastructure; Institution; Investments; Joints; K-Series Research Career Programs; Leadership; Link; Liquid substance; Longevity; Longitudinal cohort; Mediating; Mentors; Metabolism; Minority-Serving Institution; Modeling; Neurologist; Neurology; North Carolina; Participant; Pathology; Pathway interactions; Patients; Phenotype; Pilot Projects; Positioning Attribute; Prevalence; Prevention; Process; Registries; Research; Research Activity; Research Personnel; Research Support; Resources; Role; Rural Community; Schools; Sensory; Services; Surveys; Symptoms; Syndrome; Testing; Tissue Banks; Training; Training Programs; Translations; United States National Institutes of Health; Universities; Update; Vision; Work; age related; biobank; care systems; clinical biomarkers; clinical center; cohort; comorbidity; data curation; data management; data resource; data sharing; design; disease phenotype; education research; experience; human data; improved; innovation; investigator training; meetings; middle age; minority communities; neuropathology; novel; outreach; pre-clinical; programs; proteostasis; recruit; rural disparities; service engagement; statistics; translational pipeline; volunteer

ABSTRACT - OVERALL Before it kills, Alzheimer’s disease (AD) exacts a devastating toll on patients, families, caregivers, and communities. Moreover, even in 2020, there is still no prevention or cure for AD. To meet this challenge, the new Duke/University of North Carolina ADRC is poised to transform AD-related research and services across the Research Triangle and Eastern North Carolina. The new Duke/University of North Carolina Alzheimer’s Disease Research Center (Duke/UNC ADRC)’s theme is identifying age-related changes across the lifespan that mediate development, progression, and experience of Alzheimer’s disease (AD). In support of this theme, the Duke/UNC ADRC clinical cohort design and biomarker collection equips investigators with data and resources to discover new opportunities to intervene in the years before AD symptoms manifest. A related Center goal is to identify how factors that arise in early and mid-life contribute to racial and urban/rural disparities in dementia. The Center plans to provide infrastructure and resources aligned with the following specific aims: 1) Stimulate and support research on AD and Alzheimer’s disease-related dementias (AD+ADRD) for investigators from many fields by providing access to well-characterized subjects, curated data and biospecimens from diverse individuals across a wide age-spectrum with and without dementia, with emphasis on pre-clinical and early disease; 2) Attract and prepare diverse, creative, well-trained investigators to conduct high caliber research on AD+ADRD and 3) Improve lives impacted by age-related cognitive decline and increase the inclusiveness of this research. The Center’s Cores (Clinical, Biomarker, Neuropathology, Data Management and Statistics (DMS), Outreach, Recruitment, and Engagement (ORE), Administrative) and Research Education Component (REC) work collectively to pursue these aims, aided by our team’s decades of dementia outreach across North Carolina, strong existing ties to minority and rural communities, and institutional resources and experts in disparities research. The Center’s Clinical, Biomarker, and Neuropathology Cores, in conjunction with the ORE Core will support collection of images, biospecimens, and fluids from over 500 well-characterized participants across a broad age range. The DMS Core will support data curation and analysis by providing integrated data management and statistical/bioinformatics collaborative expertise. The REC will develop a robust and diverse pipeline of future leaders in AD+ADRD research through an innovative combination of widely disseminated curricular elements and more personalized mentoring experiences. The REC’s educational platforms extend to three additional Universities in our catchment area, including two majority minority institutions. The ADRC’s Cores and the REC, supported by the Administrative Core, will work in a coordinated manner to generate and store data and resources from people with and without dementia or AD risk, share data and expertise as widely as possible, and ultimately contribute back to the AD community through dissemination of results, education, and health services.

摘要 - 总体 在杀死之前，阿尔茨海默氏病（AD）对患者，家庭，看护人和 社区。此外，即使在2020年，AD仍然没有预防或治愈。为了满足这一挑战， 新杜克大学/北卡罗来纳大学ADRC被毒死，以改变广告相关的研究和服务 研究三角研究和北卡罗来纳州东部。新的北卡罗来纳州阿尔茨海默氏二公爵/大学 疾病研究中心（Duke/UNC ADRC）的主题是确定整个生命周期的变化 介导了阿尔茨海默氏病（AD）的发展，进步和经验。为了支持这个主题 Duke/UNC ADRC临床队列设计和生物标志物收集配备研究人员的数据和 在广告符号表现出来的几年中，发现新机会进行干预的资源。一个相关 中心目标是确定早期和中期中产生的因素如何促进种族和城市/农村 痴呆症的差异。该中心计划提供与以下内容保持一致的基础架构和资源 具体目的：1）刺激和支持对AD和阿尔茨海默氏病有关的痴呆症的研究 （AD+ADRD）用于许多领域的调查人员，通过提供对特征良好的受试者的访问，策划数据 以及来自有或没有痴呆症的广泛年龄谱的潜水员的生物测量， 强调临床前和早期疾病； 2）吸引和准备潜水员，富有创造力，训练有素的调查员 对AD+ADRD进行高素质研究和3）改善与年龄有关的认知能力下降影响的生活 并增加这项研究的包容性。该中心的核心（临床，生物标志物，神经病理学， 数据管理和统计（DMS），外展，招聘和参与（矿石），行政管理）和 在我们团队的数十年中，研究教育部分（REC）共同追求这些目标，以实现这些目标 整个北卡罗来纳州的痴呆症宣传，与少数民族和农村社区的现有牢固联系，以及 机构资源和差异研究专家。该中心的临床，生物标志物和 神经病理学核心与矿石核心一起支持图像，生物测量和 超过500个特征良好的参与者的流体在广泛的年龄范围内。 DMS核心将支持数据 通过提供集成的数据管理和统计/生物信息学协作来进行策划和分析 专业知识。 Rec将通过 广泛传播的课程元素和更个性化的心理的创新组合 经验。 REC的教育平台扩展到我们集水区的另外三所大学， 包括两个多数少数族裔机构。 ADRC的核心和Rec，由行政管理支持 核心，将以协调的方式工作，从和 没有痴呆症或广告风险，共享数据和专业知识尽可能广泛，最终贡献 广告社区通过传播结果，教育和卫生服务。