Clinical Core

临床核心

• 批准号: 10263710
• 负责人: Alan J Lerner
• 金额: $ 61.42万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263710
• 关键词: Address; Affect; Alleles; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Autopsy; Basic Science; Behavioral; Behavioral Symptoms; Biological Markers; Biology; Blood; Blood specimen; Brain; Cerebrospinal Fluid; Characteristics; Clinical; Clinical Data; Clinical Sciences; Cognitive; Collaborations; Collection; Communities; Consent; Data; Data Store; Dementia; Dementia with Lewy Bodies; Development; Disease; Enrollment; Functional Imaging; Future; Genetic Risk; Goals; Guidelines; Heterogeneity; Human; Image; Individual; Infrastructure; International; Language; Lewy Body Dementia; Logistics; Magnetic Resonance Imaging; Medical; Mentors; Minority Recruitment; Mission; Motor; Nerve Degeneration; Neuropsychology; Older Population; Outcome; Participant; Pathologic; Pathology; Persons; Phenotype; Population; Population Heterogeneity; Positron-Emission Tomography; Process; Registries; Research; Research Personnel; Research Support; Resources; Retrieval; Safety; Sampling Studies; Scientist; Sleep; Structure; Target Populations; Therapeutic; Therapeutic Trials; Time; Training; Translating; Update; Variant; Visual; Work; apolipoprotein E-4; base; biomarker development; brain behavior; clinical heterogeneity; cohort; community clinic; data management; data sharing; education research; ethnic diversity; experience; follow-up; imaging biomarker; inflammatory marker; insight; meetings; mild cognitive impairment; neuroimaging; neuroimaging marker; neuropathology; next generation; nuclear imaging; outreach; precision medicine; recruit; social; socioeconomics; statistics

Project Summary The theme of the Cleveland Alzheimer's Disease Center (CADRC) is focused on understanding the clinical and pathologic heterogeneity observed in Alzheimer's disease (AD) and the AD-related dementias (ADRD), which is in alignment with the broader goal of the National Alzheimer's Plan Act (NAPA). The Clinical Core (CC) and Clinical Core Registry (CCR), a key resource of the CADRC, focus on several populations that can provide special insights into this broad goal. The process of meeting this goal encompasses the major activities of the CC, which include enrolling, characterizing, and following longitudinally a diverse population of older individuals in the CCR (Specific Aims 1,2). Extensive interactions of the CC with other cores are essential for the function of the CADRC and to meet this important goal. The diverse populations targeted for furthering this goal include participants with Mild Cognitive Impairment/AD, dementia with Lewy bodies, Atypical AD dementias (Rapidly progressive/Cortical Variant AD), and a cohort of cognitively normal controls with a large proportion having at least one APOE e4 allele. A strong minority recruitment effort spanning multiple community- and clinic-based approaches is outlined and builds upon the experience of the investigators working with this community, and across cores, especially the Outreach, Recruitment, and Engagement Core (Specific Aim 6). The CC team works with the Data Management and Statistics Core to store data to facilitate future research and to share data with the National Alzheimer's Coordinating Center in a timely manner (Specific Aim 5). The CC is the starting point for collection of biomarker, imaging and post-mortem autopsies to advance our understanding of brain-behavior relationships by coordination with the Neuroimaging, Biomarker and Neuropathology Cores. This involves the collection from CCR participants of blood and cerebral spinal fluid biomarkers, 3T and 7T brain MRI and Amyloid PET imaging, and obtaining consent for post-mortem neuropathology examination with brain autopsy across all of these diverse cohorts in a culturally sensitive and efficient manner (Specific Aims 3,4). The CC is committed to support future Administrative Core development projects and the Translational Therapeutics Core and the Research Education Component in their mission to support basic scientist investigators both locally, nationally, and internationally, and training the next generation of basic and clinical science researchers (Specific Aims 7,8). Overall, the CC contributes to understanding AD in its fullest extent across cultures and its varied clinical forms, while providing vital infrastructure for the basic, social, and clinical researchers in our larger medical community.

项目摘要 克利夫兰阿尔茨海默氏病中心（CADRC）的主题专注于了解临床和 在阿尔茨海默氏病（AD）和广告相关痴呆症（ADRD）中观察到的病理异质性， 与《国家阿尔茨海默氏症计划法》（NAPA）的更广泛目标保持一致。临床核心（CC）和 CADRC的关键资源临床核心注册表（CCR）专注于几个可以提供的人群 对这个广泛目标的特殊见解。实现此目标的过程涵盖了 CC，包括参加，表征和跟随纵向的年龄较大的人群 在CCR中（特定目标1,2）。 CC与其他内核的广泛相互作用对于功能至关重要 CADRC并实现这一重要目标。促进此目标的针对性的不同人群包括 有轻度认知障碍/AD的参与者，有Lewy身体的痴呆症，非典型AD痴呆症（迅速 进行性/皮质变体AD），以及一系列认知正常对照组，有很大比例的对照 至少一个Apoe E4等位基因。跨越多个社区和诊所的少数族裔招聘工作 概述了方法，并建立在与该社区合作的调查人员的经验基础上，以及 跨核心，尤其是外展，招聘和参与核心（特定目标6）。 CC团队 与数据管理和统计核心合作以存储数据，以促进未来的研究并分享 及时与国家阿尔茨海默氏症协调中心的数据（特定目标5）。 CC是收集生物标志物，成像和验尸后的尸检的起点 通过与神经影像，生物标志物和 神经病理学核心。这涉及血液和脑脊髓液的CCR参与者的收集 生物标志物，3T和7T脑MRI和淀粉样蛋白PET成像，并获得验尸的同意 在文化敏感和 有效的方式（特定目的3,4）。 CC致力于支持未来的行政核心发展项目和翻译 在支持基础科学家的使命中，治疗核心和研究教育部分 调查人员在本地，国内和国际上都在培训下一代基本和临床 科学研究人员（具体目的7,8）。总体而言，CC最大程度地有助于理解广告 跨文化及其多样化的临床形式，同时为基本，社会和临床提供重要的基础设施 我们大型医学界的研究人员。