Genetic Literacy and Patient-Caregiver Communication of Prognostic Genetic Technology for Localized Prostate Cancer

局部前列腺癌预后基因技术的遗传素养和患者与护理人员的沟通

• 批准号: 10261503
• 负责人: Ewan Kemar Cobran
• 金额: $ 17.2万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-10 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10261503
• 关键词: Address; Adoption; Adult; African American; Alabama; Biochemical; Cancer Biology; Cancer Prognosis; Caregivers; Communication; Communities; Comprehension; Data; Diagnosis; Diffusion of Innovation; Disadvantaged; Education; Educational Background; Educational workshop; Ethnic group; Focus Groups; Funding; Genetic; Genomic medicine; Genomics; Geographic Locations; Goals; Group Interviews; Health Benefit; Health Sciences; Impairment; Incidence; Knowledge; Literature; Louisiana; Low Literacy Population; Low income; Malignant neoplasm of prostate; Maryland; Mentors; Methods; Microarray Analysis; Minority; Mission; Mississippi; National Comprehensive Cancer Network; National Human Genome Research Institute; Neoplasm Metastasis; North Carolina; Nurses; Participant; Patients; Prognosis; Prostate Cancer therapy; Prostatectomy; Public Health; Race; Radiation; Recurrence; Research; Risk; Rural; Rural Population; South Carolina; Structure; Technology; Time; Tissues; Training; Treatment outcome; United States; United States National Institutes of Health; Virginia; base; cancer education; cancer health disparity; design; directed attention; efficacy evaluation; evidence based guidelines; genetic technology; genetic testing; genome sciences; health disparity; health literacy; improved; innovation; literacy; low socioeconomic status; mRNA Expression; mathematical ability; men; mortality; next generation sequencing; novel; novel strategies; oncotype; prognostic; prognostic value; programs; randomized controlled study; skills; theories; treatment planning

Project Summary/Abstract Novel genomic technology, such as microarray analyses and next-generation sequencing, have improved the understanding of prostate cancer biology and prognosis. The National Comprehensive Cancer Network (NCCN), in 2016, recommended that patients and clinicians consider tissue-based genetic tests for localized prostate cancer. However, while much enthusiasm currently exits for the rapidly increasing field of genomic medicine, the use of multi-gene mRNA expression panels raises the potential for further divergence in prostate cancer treatment outcomes by race and low socioeconomic status. We know that health disparities persist in low income groups despite the existence of evidence-based guidelines and that adoption of state-of-the-art methods often lag behind in these groups. The goals of this NCI K01 application are to (1) explore how men with localized prostate cancer and their caregivers comprehend prognostic genetic technology, and (2) examine how an educational video about genetics impacts patient-caregiver communication of prognostic genetic technology. The study rationale is that without direct attention to genomic comprehension, the enthusiasm that exists in the rapidly increasing field of prostate cancer genomic medicine may not translate into health benefits for men with localized prostate cancer. The central hypotheses are (1) men and caregivers with lower levels of education will demonstrate a severe lack of genomic comprehension of tissue-based genetic tests for localized prostate cancer; and (2) tailored prostate cancer education, communication coaching, and a genomic literacy educational video will significantly improve patient-caregiver communication in a low literacy population. The study approach is innovative because it applies a mixed-methods community-engagement research framework to explore how African American and rural White men with localized prostate cancer, comprehend and interpret data generated from genetic technology. The proposed research is significant because of its potential to improve public health by (1) improving the understanding of prognostic genetics in minority, low income, and rural populations, and (2) engage and educate these diverse communities about genomics. The proposed research, in combination with a structured mentoring and training plan that includes didactic course and workshops, is designed to facilitate Dr. Ewan Cobran’s long term goal of developing an independently-funded research program in prostate cancer disparities, consistent with the mission of the NCI.

项目摘要/摘要 新型的基因组技术，例如微阵列分析和下一代测序，已改善 了解前列腺癌生物学和预后。国家综合癌症网络 （NCCN）在2016年建议患者和临床医生考虑基于组织的基因检测 前列腺癌。但是，尽管目前有很多热情对基因组迅速增加的领域迅速退出 医学，多基因mRNA表达面板的使用增加了前列腺进一步发散的潜力 种族和社会经济状况低下的癌症治疗结果。我们知道健康差异持续存在 低收入群体尽管存在基于证据的准则，并且采用了最先进的 在这些群体中，方法通常落后于这些方法。 该NCI K01应用的目标是（1）探讨患有局部前列腺癌及其局部性男性 看护人理解预后遗传技术，以及（2）检查有关教育视频的方式 遗传学会影响预后遗传技术的患者照顾者的沟通。研究理由是 没有直接关注基因组理解的，而是在迅速增加的领域中存在的热情 前列腺癌基因组医学可能不会转化为局部前列腺男性的健康益处 癌症。中心假设是（1）受过教育水平较低的男性和照顾者将证明 严重缺乏基于组织的基因测试对局部前列腺癌的理解； （2） 量身定制的前列腺癌教育，传播教练和基因组素养教育视频将 在低识字人群中，显着改善了患者保养者的沟通。 研究方法具有创新性，因为它应用了混合方法社区参与研究 探索非洲裔美国人和粗糙的白人局部前列腺癌的框架， 理解和解释遗传技术产生的数据。拟议的研究很重要 因为它有可能通过（1）提高对预后遗传学的理解来改善公共卫生的潜力 少数群体，低收入和农村人口，（2）与这些潜水员社区互动和教育 基因组学。拟议的研究结合了一个结构化的心理和培训计划，包括 教学课程和讲习班旨在促进Ewan Cobran博士的长期目标，即开发一个 由前列腺癌分布中的独立资助的研究计划，与 NCI。