Role of early postnatal exposure to non-persistent pesticides through breast milk on neurodevelopment

产后早期通过母乳接触非持久性农药对神经发育的作用

• 批准号: 10576859
• 负责人: Ameer Taha
• 金额: $ 23.55万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-21 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10576859
• 关键词: Address; Agriculture; Biological Assay; Blood; Brain; Carbamates; Chemicals; Child; Chlorpyrifos; Clinical assessments; Cognitive; Cognitive deficits; Data; Development; Enrollment; Exposure to; Family; Foundations; Future; General Population; Goals; Half-Life; Human; Human Milk; Impairment; Individual; Infant; Knowledge; Lactation; Learning; Link; Mass Spectrum Analysis; Maternal Exposure; Measurement; Measures; Milk; Modernization; Monitor; Neurodevelopmental Impairment; Neurodevelopmental Problem; Organophosphates; Outcome; Pesticides; Policies; Postpartum Period; Predisposition; Pregnant Women; Process; Research; Risk; Rodent; Role; Sampling; Serum; Suggestion; Testing; Time; Vulnerable Populations; Woman; Work; agricultural pesticide; autism spectrum disorder; autistic children; child bearing; cohort; early life exposure; high risk; lipophilicity; maternal serum; neurobehavioral; neurodevelopment; observational cohort study; offspring; pesticide exposure; postnatal; postnatal period; prenatal exposure; prospective; public health relevance; pyrethroid; risk mitigation; social

PROJECT SUMMARY Non-persistent pesticides are the cornerstone of modern agriculture, yet their routine application is particularly worrisome to child-bearing and lactating women in view of studies linking maternal exposures to increased risk of autism and neurodevelopmental problems in infants. The majority of studies to date have linked prenatal exposures to autism spectrum disorders and impairments in social and cognitive domains. Data on risks associated with early postnatal exposures via breast milk appears to be lacking, despite recent evidence showing the presence of non-persistent pesticides in breast milk. Additionally, it is not known which circulating pesticides accumulate in breast milk, and whether postnatal exposure risks to the infant are elevated for compounds that preferentially partition into breast milk. The goal of this proposal is to quantify an array of non-persistent pesticides in maternal breast milk and serum collected postnatally, in order to 1) relate pesticide concentrations in breast milk to the risk of neurodevelopmental impairments; 2) understand the extent of non-persistent pesticide partitioning from serum into breast milk; and 3) determine whether compounds that preferentially bioconcentrate in milk pose more of a risk to infant neurodevelopment compared to those that partition less. These objectives will be addressed in the “Markers of Autism Risk in Babies - Learning Early Signs” (MARBLES) cohort, which enrolled pregnant mothers who have had a previous child with autism spectrum disorders and therefore are at high risk of delivering another child who develops autism or atypical neurodevelopment in social and cognitive domains. We hypothesize that non-persistent pesticides that highly partition into breast milk, will be associated with increased risk of autism spectrum disorders and atypical neurodevelopment. This research will provide new information on the neurodevelopmental risks associated with early postnatal exposure to non-persistent pesticides, and determine whether these risks are specific to compounds that preferentially partition from blood to breast milk. Identifying non-persistent compounds in breast milk that may adversely impact neurodevelopment in the child, provides the basis for actively monitoring these chemicals in at-risk individuals.

项目摘要 非持久农药是现代农业的基石，但他们的常规应用尤其是 鉴于将母校暴露与风险增加联系的研究，令人担忧的是育儿和哺乳期妇女 婴儿的自闭症和神经发育问题。迄今为止的大多数研究都关联了产前 自闭症谱系障碍和社会和认知领域障碍的暴露。有关风险的数据 与早期通过母乳暴露有关的早期暴露有关，最近的证据表明 母乳中存在非持久性农药。此外，尚不清楚哪种循环农药 在母乳中积聚，以及出生后暴露于婴儿的风险是否会升高 优先分配为母乳。该提案的目的是量化一系列非持久性 产后收集的母乳和血清中的农药，以便为1）关联农药浓度 在母乳中有神经发育障碍的风险； 2）了解非持久农药的程度 从血清分割成母乳； 3）确定是否优先生物浓缩的化合物是否 与分区的牛奶相比，牛奶对婴儿神经发育的风险更大。这些目标 将在“婴儿自闭症风险标记的标记 - 学习早期迹象”（大理石）同类中解决，这是 入学的怀孕母亲患有自闭症谱系障碍的孩子，因此 交付另一个发展自闭症或非典型神经发育的孩子的高风险 域。我们假设高度分配为母乳的非持久性农药将与 自闭症谱系障碍和非典型神经发育的风险增加。这项研究将提供新的 与早期出生后接触的神经发育风险有关的信息 农药，并确定这些风险是否特定于优先分配血液的化合物 母乳。鉴定母乳中的非持久化合物，可能会对神经发育产生不利影响 在儿童中，为积极监测高危个体中的这些化学物质提供了基础。