Midcareer Development Award in Neuroaging and Geriatric Pharmacoepidemiology Research

神经衰老和老年药物流行病学研究职业中期发展奖

基本信息

批准号：
10576878
负责人：
Allison Willis
金额：
$ 16.22万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-01 至 2027-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10576878
关键词：
Address Advisory Committees Affect Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia American Anti-Cholinergics Basic Science Biological Biometry Caliber Caring Chronic Clinical Coupled Data Analyses Data Collection Data Set Dementia Dementia with Lewy Bodies Development Discipline Disease Disparity Dopaminergic Agents Drug Exposure Drug Interactions Drug Prescriptions Educational Background Elderly Electronic Health Record Environment Epidemiology Epilepsy Equity Evaluation Event Exposure to Funding Geriatrics Goals Guidelines Health Health Disparities Research Health Services Health Services Research Health system Huntington Disease Impaired cognition Individual Informatics Infrastructure Institution Intellectual functioning disability International Investigation K-Series Research Career Programs Knowledge Learning Lewy Body Dementia Link Medical Medicare claim Mentors Mentorship Methodology Mid-Career Clinical Scientist Award (K24)Minority Modeling Monitor Motor Multiple Sclerosis Neighborhoods Neurologic Neurologic Dysfunctions Neurologist Neurology Observational Study Outcome Parkinson Disease Parkinson&apos s Dementia Patients Pennsylvania Pharmaceutical Preparations Pharmacoepidemiology Pharmacology Pharmacotherapy Population Process Psychiatry Public Health Quality of Care Reporting Research Research Design Research Infrastructure Research Methodology Research Personnel Risk Role Safety Sampling System Time Training Training Programs Traumatic Brain Injury Treatment outcome Universities access disparities analytic epidemiology care delivery care outcomes career chronic neurologic disease clinical practice cognitive function collaborative environment dementia risk design disparity reduction drug development epidemiology study evidence base health care disparity health care service utilization health disparity health equity health service use high risk improved innovation insight medical specialties mild cognitive impairment mixed dementia multidisciplinary neighborhood disadvantage nervous system disorder neuroprotection next generation novel outcome disparities patient oriented patient oriented research poor health outcome programs prospective recruit research and development social factors success treatment adherence

Address Advisory Committees Affect Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia American Anti-Cholinergics Basic Science Biological Biometry Caliber Caring Chronic Clinical Coupled Data Analyses Data Collection Data Set Dementia Dementia with Lewy Bodies Development Discipline Disease Disparity Dopaminergic Agents Drug Exposure Drug Interactions Drug Prescriptions Educational Background Elderly Electronic Health Record Environment Epidemiology Epilepsy Equity Evaluation Event Exposure to Funding Geriatrics Goals Guidelines Health Health Disparities Research Health Services Health Services Research Health system Huntington Disease Impaired cognition Individual Informatics Infrastructure Institution Intellectual functioning disability International Investigation K-Series Research Career Programs Knowledge Learning Lewy Body Dementia Link Medical Medicare claim Mentors Mentorship Methodology Mid-Career Clinical Scientist Award (K24)Minority Modeling Monitor Motor Multiple Sclerosis Neighborhoods Neurologic Neurologic Dysfunctions Neurologist Neurology Observational Study Outcome Parkinson Disease Parkinson&apos s Dementia Patients Pennsylvania Pharmaceutical Preparations Pharmacoepidemiology Pharmacology Pharmacotherapy Population Process Psychiatry Public Health Quality of Care Reporting Research Research Design Research Infrastructure Research Methodology Research Personnel Risk Role Safety Sampling System Time Training Training Programs Traumatic Brain Injury Treatment outcome Universities access disparities analytic epidemiology care delivery care outcomes career chronic neurologic disease clinical practice cognitive function collaborative environment dementia risk design disparity reduction drug development epidemiology study evidence base health care disparity health care service utilization health disparity health equity health service use high risk improved innovation insight medical specialties mild cognitive impairment mixed dementia multidisciplinary neighborhood disadvantage nervous system disorder neuroprotection next generation novel outcome disparities patient oriented patient oriented research poor health outcome programs prospective recruit research and development social factors success treatment adherence

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项目摘要

Dr. Willis is a neurologist, neuroepidemiologist, and health services researcher who has established a nationally- and internationally- recognized, independently funded research program committed to patient-oriented research focused on drug effects, care process and outcome disparities, and health service use in older adults with neurological disease. She has a successful record in mentoring trainees who approach POR from multiple educational backgrounds. Proposal aims: (1) to conduct analytical epidemiology research examining the impact of prescribing practices, drug exposures, drug-drug and drug-disease interactions on clinical, patient-reported and health care utilization outcomes in older adults, particularly those with Parkinson Disease + Dementia; Dementia with Lewy Bodies (which together comprise Lewy Body Dementia, an Alzheimer’s Disease Related Dementia/ADRD), Alzheimer’s disease (AD), Mild cognitive impairment and chronic neurological disease; (2) to conduct health disparities and health services research in older adults with neurological disease, particularly those with the above ADRDs and AD, to gain actionable insights into systematic barriers to equal care; (3a) to develop new studies at the intersection of aging, neurology, and pharmacoepidemiology focused on the biological, clinical, and qualitative effects of deprescribing and safety-guided CNS drug prescribing on cognitive function and cognitive decline in individuals with the above ADRDs, AD, and MCI; (3b) to develop new studies at the intersection of aging, disparities, and health services research, focused on describing and decomposing the relative contributions of individual, neighborhood, and social factors on disparities in guideline adherent treatment initiation, escalation, and monitoring; treatment adherence and outcomes in older adults with neurological disease, including ADRDs and AD; (4) to use Dr. Willis’s research program to train and mentor new investigators in research methods that will improve health care outcomes for older adults with ADRDs, AD and chronic neurological disorders through neuroprotective prescribing, more effective and equitable care delivery. A K24 award will provide Dr. Willis with the protected time needed to develop new research focused on neuroprotective prescribing and health disparities, generate knowledge on the drivers and effects of medical care and drug therapies for neurological disorders. A K24 will also allow Dr. Willis to increase her mentoring expertise and develop a formal mentoring program for engaging young investigators drawn from neurology, epidemiology, geriatrics, psychiatry, pharmacology, informatics, and biostatistics. Dr. Willis’s mentoring program will (1) provide mentees with direct exposure to primary data collection and secondary data analysis (2) create an interdisciplinary environment where trainees from a range of specialties will learn directly from each other (3) provide mentees with individualized research and career mentoring from her. The outstanding institutional environment and the K24 Advisory Team Dr. Willis has assembled to monitor and guide her progress at the University of Pennsylvania support the success of this proposal.

威利斯博士是一名神经科学家，神经增活医生和卫生服务研究人员，他建立了一项全国性和国际认可的独立研究计划，致力于致力于患者的研究，专注于药物影响，护理过程和结果分布，以及在患有神经疾病的老年人中的卫生服务。她在心理学员方面有着成功的记录，他们从多个教育背景接近POR。提案的目的：（1）进行分析流行病学研究研究，研究开处方实践，药物暴露，药物 - 药物和药物疾病相互作用对老年人的临床，患者报告和医疗保健利用结果的影响，尤其是患有帕金森病 +痴呆症的老年人； Lewy身体的痴呆症（结合了Lewy身体痴呆，阿尔茨海默氏病有关的痴呆症/Adrd），阿尔茨海默氏病（AD），轻度认知障碍和慢性神经系统疾病；（2）在患有神经系统疾病的老年人，尤其是患有上述ADRD和AD的老年人中进行健康分配和卫生服务研究，以获得对同等护理的系统障碍的可行见解；（3a）在衰老，神经病学和药物epidemiology的交集上开发新的研究，重点介绍了在上述ADRDS，AD和MCI和MCI和MCI的个体中，脱落和安全引入的CNS药物对认知功能和认知下降的认知功能和认知下降的生物学，临床和定性作用；（3B）在衰老，差异和卫生服务研究的交集上开发新的研究，重点是描述和分解个人，邻里和社会因素对指南添加剂治疗计划，升级和监测的相对贡献；包括ADRD和AD在内的神经系统疾病的老年人的治疗依从性和结果；（4）使用威利斯博士的研究计划来培训和指导新的研究人员研究方法，以改善ADRDS，AD和慢性神经系统疾病的老年人的医疗保健成果，通过神经保护性疾病，更有效，更有效，更公平的护理。 K24奖将为Willis博士提供开发针对神经保护处方和健康差异的新研究所需的保护时间，从而对神经系统疾病的医疗保健和药物疗法的驱动因素和影响产生知识。 K24还将允许威利斯博士提高她的心理专业知识，并制定正式的心理计划，以吸引来自神经病学，流行病学，老年医学，精神病学，药理学，知情和生物统计学的年轻研究人员。威利斯博士的心理计划（1）将为Mentores提供直接接触主要数据收集和二级数据分析（2）创建一个跨学科环境，其中一系列专业的受训者将直接互相学习（3）为Mentores提供了个性化的研究和职业指导。杰出的机构环境和K24咨询团队威利斯博士已经组装了监视和指导她在宾夕法尼亚大学的进步，这支持了该提案的成功。