Pulmonary Immunopathology

肺部免疫病理学

基本信息

批准号：
10588207
负责人：
Yogesh Saini
金额：
$ 36.51万
依托单位：
LOUISIANA STATE UNIV A&M COL BATON ROUGE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-01-02 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10588207
关键词：
Acute Lung Injury Address Allergens Animal Husbandry Animals Bacteria Biology Biomedical Research Board Certification Bronchoalveolar Lavage Fluid Cardiovascular Diseases Cell Culture Techniques Cell Separation Cells Censuses Centers of Research Excellence Collaborations Communities Computer software Consult Consultations Containment of Biohazards Contract Services Data Data Correlations Disease Disease model Educational workshop Ensure Enzyme-Linked Immunosorbent Assay Equipment Experimental Designs Extrinsic asthma Faculty Faculty Recruitment Flow Cytometry Funding Future Genetic Engineering Genetically Engineered Mouse Genotype Goals Heart Rate Histologic Histology Histopathology Immunohistochemistry Immunologics Immunology Individual Infection Inflammation Inflammatory Influenza Institution Knock-out Laboratories Lesion Louisiana Lung Lung diseases Maintenance Measurement Measures Microbe Modeling Mus Organ Outcome Pathogenesis Pathologic Pathologist Phase Physiological Physiology Postdoctoral Fellow Preparation Productivity Reagent Research Research Personnel Resources Sampling Serum Services Standardization Structure Students Techniques Temperature Training Training and Education Transgenic Organisms Tuberculosis Underrepresented Minority United States National Institutes of Health Update Viral airway inflammation chemokine cytokine experience graduate student immunopathology improved instrumentation laser capture microdissection lectures member microbial morphometry mouse model programs pulmonary function recruit repaired success undergraduate student

项目摘要

PROJECT SUMMARY Pulmonary Immunopathology (PIP) core offers expertise and technical support for investigators in the COBRE program. The goal of the proposed PIP Core is to provide animal and equipment facilities and specialized training for COBRE PJIs in pulmonary immunopathological techniques and to develop new experimental approaches that will assist Promising Junior Investigators (PJls) and other NIH-funded investigators to successfully pursue their research objectives. The establishment of this core will facilitate collaboration among investigators and members of the biomedical research community in Louisiana. This core will also educate our underrepresented minority (URM) undergraduate students, graduate students, postdoctoral fellows, summer scholars (DVM Students) with the application and the current advances in pulmonary immunology through lectures, laboratory classes, and workshops. In order to ensure the success of the COBRE in Lung Biology and Disease and of our COBRE PJIs, establishment of the PIP Core is essential to meet the current and future needs of LSU and other institutions because this is the only PIP core in the state of Louisiana. Thus, the PIP Core is intended to be a permanent core at LSU that we will establish, expand, and transit to an independent core during the 15-year COBRE support. The PIP Core has established 3 specific aims. Aim 1 is to centralize management of wild-type (control) and mouse genetically engineered mouse colonies and immunological reagents. Aim 2 is to provide the COBRE and other biomedical investigators with resources on comprehensive immunopathological assessments for mice, including instrumentation, technical support and consultation. Aim 3 is to educate faculty, staff, postdoctoral fellows, graduate students, undergraduate students and summer scholars regarding the application and the current advances in immunopathological assessments for mice.

项目摘要肺免疫病理学（PIP）核心为毛c的研究人员提供专业知识和技术支持程序。拟议的PIP核心的目标是提供动物和设备设施和专业在肺部免疫病理技术中培训毛皮PJIS并开发新的实验将有助于有前途的初级调查人员（PJLS）和其他NIH资助的调查人员的方法成功追求他们的研究目标。建立这个核心将有助于合作路易斯安那州生物医学研究社区的研究人员和成员。这个核心也将教育我们代表性不足的少数民族（URM）本科生，研究生，博士后研究员，夏季学者（DVM学生）以及肺部目前的进步通过讲座，实验室课程和研讨会的免疫学。为了确保成功肺部生物学和疾病的毛病以及我们的cobre pjis，建立PIP核心对于满足LSU和其他机构的当前和未来需求，因为这是状态下唯一的PIP核心路易斯安那州。因此，PIP核心旨在成为LSU的永久核心，我们将建立，扩展和在15年的毛培养支持期间转移到独立核心。 PIP核心已经建立了3个特定的目标。目标1是集中野生型（对照）和鼠标基因工程鼠标的管理菌落和免疫学试剂。 AIM 2是为毛病和其他生物医学研究人员提供有关小鼠的全面免疫病理评估的资源，包括仪器，技术支持和咨询。 AIM 3是教育教师，员工，博士后研究员，研究生，有关申请的本科生和夏季学者小鼠的免疫病理评估。