Center for Lung Biology and Disease

肺生物学与疾病中心

• 批准号: 10588205
• 负责人: TAMMY R DUGAS
• 金额: $ 223.6万
• 依托单位: LOUISIANA STATE UNIV A&M COL BATON ROUGE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-02 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10588205
• 关键词: Acceleration; Acute Lung Injury; Advisory Committees; Allergens; Alveolar Macrophages; Animals; Antigen-Antibody Complex; Area; Award; Basic Science; Biology; Biomedical Research; Cells; Centers of Research Excellence; Clinical; Collaborations; Contract Services; Core Facility; Dedications; Development; Discipline; Disease; Economic Development; Educational workshop; Ensure; Environment; Equipment; Ethics; Extramural Activities; Extrinsic asthma; Feedback; Fostering; Funding; Future; Goals; Grant; Human; Immune response; Immunologics; Immunology; Individual; Infectious Diseases Research; Influenza; Infrastructure; Institution; Interdisciplinary Study; International; Life; Louisiana; Lung; Lung diseases; Mentored Research Scientist Development Award; Mentors; Modeling; Molecular; Molecular Biology; Mus; National Institute of General Medical Sciences; Pathogenesis; Pathologic; Phase; Population; Pre-Clinical Model; Process; Productivity; Pulmonary Inflammation; Recording of previous events; Records; Regulation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Respiratory Disease; Sampling; Senior Scientist; Signaling Molecule; Solid; Stimulus; Strategic Planning; T-Lymphocyte Subsets; Tuberculosis; United States National Institutes of Health; Universities; Veterinary Medicine; Veterinary Schools; Viral; Wages; Writing; career; career development; design; eosinophil; experience; immune function; immunopathology; improved; innovation; insight; interest; multidisciplinary; neutrophil; nonhuman primate; novel; prevent; programs; recruit; research and development

ABSTRACT The objective of this proposal is to establish a Center of Excellence (COE) in Pulmonary Diseases that is highly interactive and consists of a dynamic group of junior investigators whose research focus is on understanding the molecular and cellular immunological mechanisms associated with the pathogenesis if lung diseases. The Promising Junior Investigators (PJIs) have proposed four independent but complementary research projects that will use molecular, immunological, and pathological approaches to investigate lung diseases in mouse and non-human primate models. They will also use de-identified human samples to validate their findings from preclinical models. We will determine the host signaling molecules, such as IDO, ITK, IL4Rand TTP in the initiation of protective host immune responses to infectious (bacterial/viral) and non-infectious agents (allergens). The long-term goal is to establish a collaborative, productive, sustainable, and nationally/internationally recognized COE in Pulmonary Disease research. The Specific Aims are: 1. To promote the establishment of a nationally/internationally recognized COE in Pulmonary Diseases. With the support of LSU, this COBRE-funded center will ensure that the pulmonary disease research group is sustainable and will provide much-needed resources to expand this research area which is primarily supported by the state of Louisiana; 2. To facilitate the improvement in research infrastructure for enhancing competitiveness for extramural grants. In addition to existing core facilities through NIGMS-funded COBRE-III, INBRE, and Louisiana Clinical and Translational Center (LA CaTS) in Baton Rouge, we will establish two scientific cores, such as Pulmonary Immunopathology and Molecular Biology. We will also renovate the office spaces into conventional animal holding and equipment rooms to have a dedicates suite for COBRE investigators. We will recruit 2 PJIs with complementary research areas in 2-3 years and 6 PJIs for the entire COBRE-I duration. The LSU School of Veterinary Medicine (SVM) has committed to purchase of new equipment, provide service contracts and the COBRE will offer salaries to scientific and technical staff; and 3. To develop an administrative infrastructure to promote the independent career of PJIs. We have assembled senior scientists with outstanding track record to serve on the Internal Scientific and advisory committee (ISAC), external advisory board (EAB), and mentoring committee (MC) that will carefully evaluate scientific needs of each PJI and tailor the mentoring plan based on the individual’s need. Two mentors: one local (Baton Rouge) and one outside LSU (Louisiana) have been assigned. The PJIs will attend career development workshops and will participate in ethics and scientific writing. We will nominate PJIs for the NIH/CSR Early Career Grant Reviewer program. We will also assist PJIs with their presentations to the ISAC, EAB, and MC to seek their feedback on their grants submissions. The team assembled here is exceptionally matched to the research goals, complementary expertise in lung immunology, multidisciplinary, and has a solid history of productive collaboration. This COBRE program will provide novel insights into the pathogenesis of devastating lung diseases that guide future improved strategies to treating and preventing these and other lung diseases in human population.

抽象的 该提议的目的是在肺部疾病中建立卓越中心（COE） 这是高度互动的，由一个动态的初级研究人员组成，其研究重点 正在理解与 发病机理如果肺部疾病。有前途的初级调查员（PJIS）提出了四个 独立但完整的研究项目，这些项目将使用分子，免疫学和 研究小鼠和非人类灵长类动物模型中肺部疾病的病理方法。他们 还将使用去识别的人类样品从临床前模型验证其发现。我们将 确定宿主信号分子，例如IDO，ITK，IL4R和TTP。 保护性宿主对感染性（细菌/病毒）和非感染剂（过敏原）的免疫反应。 长期目标是建立协作，富有成效，可持续性，并 肺部疾病研究中的国家/国际公认的COE。具体目的是：1。 促进在肺部疾病中建立全国/国际认可的COE。 在LSU的支持下，这个由毛病资助的中心确保了肺部疾病研究 团体是可持续的，将提供急需的资源来扩展该研究领域 主要得到路易斯安那州的支持； 2。促进研究的改进 基础设施，以增强壁外赠款的竞争力。除了现有核心 通过NIGMS资助的Cobre-III，Inbre和Louisiana临床和转化中心的设施 （La Cats）在巴吞鲁日（Baton Rouge），我们将建立两个科学核心，例如肺部 免疫病理学和分子生物学。我们还将将办公空间翻新成常规 动物持有和设备室，为毛毛调查人员提供专用套件。我们将 2 - 3年内的Rectuit 2 PJI，具有完整的研究领域，整个Cobre-I的6个PJIS和6个PJI 期间。 LSU兽医学院（SVM）已承诺购买新的 设备，提供服务合同，毛绒将为科学和技术提供薪水 职员;和3。建立一种行政基础设施来促进PJI的独立职业。 我们已经组建了高级科学家，并具有出色的往绩记录，以服务于内部科学 和咨询委员会（ISAC），外部顾问委员会（EAB）和心理委员会（MC）（MC） 将仔细评估每个PJI的科学需求，并根据 个人的需要。两位导师：一名本地（巴吞鲁日）和LSU以外的一位（路易斯安那州） 分配。 PJIS将参加职业发展研讨会，并将参加道德规范 科学写作。我们将提名PJIS参加NIH/CSR早期职业赠款审查员计划。我们 还将协助PJIS向ISAC，EAB和MC进行演讲，以寻求他们的反馈 赠款提交。这里组装的团队与研究目标非常匹配， 在肺部免疫学，多学科，具有扎实的产品史上完全专业知识 合作。该毛线计划将为毁灭性的发病机理提供新的见解 肺部疾病指导未来的改进策略来治疗和防止这些肺和其他肺 人口中的疾病。

项目成果

Higher susceptibility of males to bleomycin-induced pulmonary inflammation is associated with sex-specific transcriptomic differences in myeloid cells.

• DOI: 10.1016/j.taap.2022.116228
• 发表时间: 2022-11-01
• 期刊: Toxicology and applied pharmacology
• 影响因子: 3.8
• 作者: Lamichhane R;Patial S;Saini Y
• 通讯作者: Saini Y

In utero exposures to mint-flavored JUUL aerosol impair lung development and aggravate house dust mite-induced asthma in adult offspring mice.

• DOI: 10.1016/j.tox.2022.153272
• 发表时间: 2022-07
• 期刊: TOXICOLOGY
• 影响因子: 4.5
• 作者: Cahill, Kerin M.;Johnson, Trenton K.;Perveen, Zakia;Schexnayder, Matthew;Xiao, Rui;Heffernan, Linda M.;Langohr, Ingeborg M.;Paulsen, Daniel B.;Penn, Arthur L.;Noel, Alexandra
• 通讯作者: Noel, Alexandra

The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice.

• DOI: 10.4049/jimmunol.2000530
• 发表时间: 2020-09-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Lewis BW;Choudhary I;Paudel K;Mao Y;Sharma R;Wang Y;Deshane JS;Boucher RC;Patial S;Saini Y
• 通讯作者: Saini Y

Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development.

• DOI: 10.1016/j.celrep.2023.112166
• 发表时间: 2023-03-28
• 期刊: Cell reports
• 影响因子: 8.8

Ablation of IL-33 Suppresses Th2 Responses but Is Accompanied by Sustained Mucus Obstruction in the Scnn1b Transgenic Mouse Model.

• DOI: 10.4049/jimmunol.1900234
• 发表时间: 2020-03-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Lewis BW;Vo T;Choudhary I;Kidder A;Bathula C;Ehre C;Wakamatsu N;Patial S;Saini Y
• 通讯作者: Saini Y