Integration of epigenetic and non-coding RNA mechanism in leukemia

表观遗传和非编码RNA机制在白血病中的整合

• 批准号: 10582327
• 负责人: Sara E Meyer
• 金额: $ 34.97万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10582327
• 关键词: Acute Myelocytic Leukemia; Adult; Affect; Agonist; Binding; Biotinylation; CXCL9 gene; Characteristics; Chemoresistance; Child; Clinical; Clustered Regularly Interspaced Short Palindromic Repeats; Compensation; Cytotoxic Chemotherapy; DNA; DNA Methylation; DNA Modification Methylases; DNMT3a; DNMT3a mutation; Data; Dependence; Disease; Epigenetic Process; Event; Exhibits; FLT3 gene; Gene Expression; Gene Expression Profile; Gene Expression Regulation; Genes; Genetic Transcription; Growth; Hematopoietic Neoplasms; Hematopoietic stem cells; Human; IRAK4 gene; Immune signaling; Maintenance; Messenger RNA; Methyltransferase; MicroRNAs; Mus; Mutation; Myelogenous; Myeloid Leukemia; Outcome; Output; Pathogenesis; Patients; Phosphotransferases; RELA gene; Receptor Protein-Tyrosine Kinases; Receptor Signaling; Regulator Genes; Repression; Signal Transduction; TLR7 gene; Testing; Therapeutic; Toll-Like Receptor Pathway; Toll-like receptors; Untranslated RNA; acute myeloid leukemia cell; cell growth; chemokine; cytokine; genomic locus; high risk; in vivo; innovation; leukemia; leukemia initiating cell; leukemic stem cell; leukemic transformation; leukemogenesis; loss of function; mouse model; mutant; novel; overexpression; restoration; self-renewal; stemness; therapeutic evaluation

N/A

不适用

项目成果

Context is key for FLT3-ITD.

上下文是 FLT3-ITD 的关键。

• DOI: 10.1182/blood.2022019135
• 发表时间: 2023
• 期刊: Blood
• 影响因子: 20.3
• 作者: Meyer,SaraE