VisualSonics Vevo 2100

威视 Vevo 2100

• 批准号: 7794593
• 负责人: Burns C Blaxall
• 金额: $ 44.55万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794593
• 关键词: Academic Medical Centers; Animal Experimentation; Animals; Arts; Cardiovascular system; Clinical and Translational Science Awards; Color; Commit; Discipline; Doctor of Philosophy; Faculty; Fostering; Functional disorder; Funding; Growth; Housing; Image; Individual; Lymphatic; Malignant Neoplasms; Medical center; Methods; Modality; Musculoskeletal Diseases; Nature; Operative Surgical Procedures; Perfusion; Physiologic pulse; Program Research Project Grants; Research; Research Design; Research Institute; Research Personnel; Resolution; Running; System; Time; Tissues; Training; Training Support; Transducers; Translational Research; Ultrasonography; Universities; base; cardiovascular imaging; cost; experience; fetal; hospice environment; imaging modality; instrument; instrumentation; interest; malformation; programs; public health relevance; reconstruction; skills

DESCRIPTION (provided by applicant): We are requesting funds to purchase a VisualSonics Vevo 2100 ultrasound imaging system for incorporation into the small animal Ultrasound Imaging Core at the University of Rochester Medical Center (URMC), an original awardee of the Clinical and Translational Science Award. VisualSonics is the only company in the world that manufactures high-resolution ultrasound imaging modalities targeted specifically to research animals. The newly introduced Vevo 2100 is a revolutionary, state of the art high-resolution ultrasound imaging system specifically designed for research animals. The Vevo 2100 has several enhancements over the earlier Vevo 770, including linear array transducers (probes), strain imaging, tissue doppler imaging, pulse wave Doppler, color Doppler, power Doppler, 3D reconstruction, contrast imaging, and contrast perfusion imaging. These new modalities provide unparalleled, revolutionary advancements regarding all aspects of non-invasive longitudinal cardiovascular imaging in particular, and small animal imaging in general. The Aab Cardiovascular Research Institute (Aab CVRI) at the University of Rochester Medical Center (URMC) currently has over three years experience operating a Vevo 770 in cardiovascular projects, including our Program Project Grant (B Berk, PI). This instrument is heavily used by investigators both within the Aab CVRI and throughout the URMC, and is near capacity. Due to the increased demand for non-invasive imaging of small animals, the current instrumentation within the URMC is no longer adequate. The Vevo 2100 provides unique imaging capabilities that are unavailable with the Vevo 770. To broaden access to the transformative nature of small animal ultrasound imaging, the current Vevo 770 will be upgraded using already committed institutional funds, and will be moved to the main URMC campus where it will broaden the availability of ultrasound imaging to a cadre of well funded investigators with well-established interest and expertise in ultrasound imaging. The availability of both machines will serve to expand the availability of high-resolution ultrasound imaging while at the same time expanding our imaging capabilities. The Vevo 2100 will housed in the Aab CVRI Surgery/Imaging Core under the hospice of the institutional Ultrasound Core. Within the Aab CVRI, the Vevo system is utilized, run and managed by a group of 18 well-funded PhD and MD investigators with extensive ultrasound imaging experience. In addition, well-trained support staff are in place to run the machine and to train new users of both the Vevo 2100 and Vevo 770. In summary, the transformative nature of the Vevo 2100 and expanded availability of small animal ultrasound imaging would not only maintain both the Aab CVRI and URMC at the cutting edge of translational research, but would further enhance our ability to attract the best and brightest cardiovascular investigators, produce sought-after trainees with cutting edge training and marketable skills, and foster continued, long-term growth of both the Aab CVRI and URMC funding and faculty, creating opportunities for numerous individual R01s and Program Project Grants across multiple disciplines. PUBLIC HEALTH RELEVANCE: Advanced small animal ultrasound imaging permits non-invasive tissue imaging, enabling enormous refinement in investigational methods that can also reduce the numbers of animals used. The Aab Cardiovascular Research Institute has an established ultrasound-based research program that will take full advantage of the VisualSonics Vevo 2100, a new state-of-the-art instrument. In a cost-effective expansion of ultrasound imaging to the entire University of Rochester Medical Center, the existing instrument will be upgraded and relocated to the main medical center campus, thus transforming both cardiovascular research and existing research programs in cancer, musculoskeletal disease, lymphatic dysfunction, and fetal malformation.

描述（由申请人提供）：我们正在申请资金购买 VisualSonics Vevo 2100 超声成像系统，以纳入罗切斯特大学医学中心 (URMC) 的小动物超声成像核心，该中心是临床和转化科学奖的原始获奖者。 VisualSonics 是世界上唯一一家生产专门针对研究动物的高分辨率超声成像模式的公司。新推出的 Vevo 2100 是一款革命性的、最先进的高分辨率超声成像系统，专为研究动物而设计。 Vevo 2100 比早期的 Vevo 770 有多项增强功能，包括线性阵列换能器（探头）、应变成像、组织多普勒成像、脉冲波多普勒、彩色多普勒、功率多普勒、3D 重建、对比成像和对比灌注成像。这些新模式在无创纵向心血管成像（特别是小动物成像）的各个方面提供了无与伦比的革命性进步。罗切斯特大学医学中心 (URMC) 的 Aab 心血管研究所 (Aab CVRI) 目前在心血管项目中拥有三年多操作 Vevo 770 的经验，包括我们的计划项目资助金（B Berk，PI）。该仪器被 Aab CVRI 和整个 URMC 的调查人员大量使用，并且已接近饱和。由于对小动物非侵入性成像的需求不断增加，URMC 内当前的仪器已不再足够。 Vevo 2100 提供 Vevo 770 所不具备的独特成像功能。为了扩大小动物超声成像变革性的应用范围，当前的 Vevo 770 将使用已承诺的机构资金进行升级，并将移至 URMC 主校区它将扩大超声成像的可用性，让一批资金雄厚、对超声成像有浓厚兴趣和专业知识的研究人员受益。两台机器的可用性将有助于扩大高分辨率超声成像的可用性，同时扩大我们的成像能力。 Vevo 2100 将安装在机构超声核心临终关怀下的 Aab CVRI 手术/成像核心中。在 Aab CVRI 内，Vevo 系统由 18 名资金雄厚、拥有丰富超声成像经验的博士和医学博士研究人员使用、运行和管理。此外，训练有素的支持人员已到位来运行机器并培训 Vevo 2100 和 Vevo 770 的新用户。总之，Vevo 2100 的变革性和小动物超声成像的扩展可用性不仅将保持 Aab CVRI 和 URMC 处于转化研究的前沿，但将进一步增强我们吸引最优秀和最聪明的心血管研究人员的能力，培养受过尖端培训和适销对路的受训人员技能，并促进 Aab CVRI 和 URMC 资金和师资的持续、长期增长，为跨多个学科的众多个人 R01 和计划项目拨款创造机会。 公共卫生相关性：先进的小动物超声成像可以实现非侵入性组织成像，从而极大地改进研究方法，同时减少使用的动物数量。 Aab 心血管研究所已建立了基于超声的研究项目，该项目将充分利用最先进的新型仪器 VisualSonics Vevo 2100。为了以经济高效的方式将超声成像扩展到整个罗切斯特大学医学中心，现有仪器将进行升级并搬迁到主医疗中心园区，从而改变心血管研究以及癌症、肌肉骨骼疾病、淋巴功能障碍方面的现有研究项目，以及胎儿畸形。