Pharmacology of Stimulant Choice

兴奋剂选择的药理学

基本信息

批准号：
10585535
负责人：
Matthew L Banks
金额：
$ 34.93万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-15 至 2028-02-29
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10585535
关键词：
Acceleration Admission activity Agonist Animals Attenuated Basic Science Behavior Behavioral Biological Assay Biosensor CHRM1 gene Cessation of life Cholinergic Agonists Clinical Clinical Data Clinical Trials Cocaine Cocaine Abuse Cocaine use disorder Data Decision Making Development Dopamine Dose Drug Addiction Drug Use Disorder Effectiveness Experimental Designs Failure Female Food Funding Human Laboratory Animals Laboratory Study Measures Mediator Methamphetamine Methamphetamine use disorder Microdialysis Modeling Monitor Muscarinic Acetylcholine Receptor Muscarinics National Institute of Drug Abuse Negative Reinforcements Neurobiology Neurotransmitters Nucleus Accumbens Pharmaceutical Preparations Pharmacology Pharmacotherapy Prefrontal Cortex Procedures Public Health Publications Rattus Research Research Subjects Self Administration Series Serotonin Agonists Signal Transduction Source Stimulant System Testing Time United States Food and Drug Administration United States National Institutes of Health Work antagonist effectiveness evaluation experimental study human subject in vivo male methamphetamine abuse non-drug overdose death pharmacologic pre-clinical reinforcer social stimulant abuse stimulant misuse stimulant use disorder therapeutic candidate

Acceleration Admission activity Agonist Animals Attenuated Basic Science Behavior Behavioral Biological Assay Biosensor CHRM1 gene Cessation of life Cholinergic Agonists Clinical Clinical Data Clinical Trials Cocaine Cocaine Abuse Cocaine use disorder Data Decision Making Development Dopamine Dose Drug Addiction Drug Use Disorder Effectiveness Experimental Designs Failure Female Food Funding Human Laboratory Animals Laboratory Study Measures Mediator Methamphetamine Methamphetamine use disorder Microdialysis Modeling Monitor Muscarinic Acetylcholine Receptor Muscarinics National Institute of Drug Abuse Negative Reinforcements Neurobiology Neurotransmitters Nucleus Accumbens Pharmaceutical Preparations Pharmacology Pharmacotherapy Prefrontal Cortex Procedures Public Health Publications Rattus Research Research Subjects Self Administration Series Serotonin Agonists Signal Transduction Source Stimulant System Testing Time United States Food and Drug Administration United States National Institutes of Health Work antagonist effectiveness evaluation experimental study human subject in vivo male methamphetamine abuse non-drug overdose death pharmacologic pre-clinical reinforcer social stimulant abuse stimulant misuse stimulant use disorder therapeutic candidate

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项目摘要

This new R01 application proposes a systematic series of experiments focused on drug-choice procedures in male and female rats to evaluate the muscarinic acetylcholine receptor (mAChR)1 agonist VU0364572 as a candidate medication for treatment of cocaine and methamphetamine use disorder. This application is founded on the premise that stimulant use disorder in humans can be studied using preclinical assays of drug-vs-food choice that model clinical aspects of behavioral misallocation and decision making between concurrently available drugs and an alternative nondrug reinforcer. We propose to determine 1) VU0364572 effects on cocaine-food and cocaine-social choice, 2) VU0364572 effects on methamphetamine-food and methamphetamine-social choice, and 3) VU0364572 effects on nucleus accumbens and prefrontal cortex dopamine release using dLight.

这种新的R01应用提出了一系列系统的实验，该实验侧重于药物选择程序雄性和雌性大鼠评估毒蕈碱乙酰胆碱受体（MACHR）1激动剂VU0364572作为A 候选药物治疗可卡因和甲基苯丙胺使用障碍。该申请是建立的就可以使用药物vs食品的临床前测定来研究人类中刺激性障碍的前提选择该模型的行为分配和决策的临床方面同时进行可用的药物和替代的非果钢筋。我们建议确定1）VU0364572对可卡因食品和可卡因社会选择，2）VU0364572对甲基苯丙胺食品和甲基苯丙胺 - 社会选择和3）VU0364572对伏隔核和前额叶皮层的影响使用Dlight释放多巴胺。