Appalachian Node

阿巴拉契亚节点

基本信息

批准号：
10581482
负责人：
JANE M LIEBSCHUTZ
金额：
$ 96.91万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-15 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10581482
关键词：
Academic Medical Centers Address Appalachian Region Area Bacterial Infections Bioinformatics Caring Clinical Clinical Investigator Clinical Research Clinical Sciences Clinical Trials Network Coal Coal Mining Collaborations Communities Complex County Data Databases Discipline Distress Economics Electronic Health Record Employment Opportunities Endocarditis Ensure Environmental Risk Factor Epidemic Evidence based practice Family Geography HIV Health Health Information System Health Policy Health Technology Health system Healthcare Healthcare Systems Helping to End Addiction Long-term Hepatitis B Hepatitis C Incentives Industry Infrastructure Institution Insurance Carriers Integrated Health Care Systems Intervention Kentucky Leadership Learning Life Expectancy Long-Term Care Manuals Medical Medicine Morbidity - disease rate National Institute of Drug Abuse Neonatal Abstinence Syndrome Ohio Opiate Addiction Opioid Overdose Patients Pennsylvania Persons Pharmaceutical Preparations Pharmacists Pharmacy facility Play Policies Policy Maker Professional Education Protocols documentation Provider Public Health Publications Records Recovery Research Research Personnel Resource-limited setting Resources Risk Risk Factors Role Rural Series Site System Tennessee Testing Training Programs Translational Research Transportation Underserved Population Unemployment United States National Institutes of Health Universities West Virginia Work addiction buprenorphine treatment chronic pain college evidence base experience improved injection drug use innovation marginalization mobile computing mortality multi-site trial multidisciplinary novel opioid epidemic opioid misuse opioid mortality opioid overdose opioid use opioid use disorder outreach overdose death peer peer recovery practice-based research network programs recruit relapse risk response rural area rural counties rurality smartphone application social substance misuse substance use substance use treatment syndemic treatment program underserved rural area urban area wearable device

项目摘要

Abstract: The Appalachian Node of NIDA Clinical Trials Network (CTN) will address clinical research questions that arise from Central Appalachia, an epicenter of the current opioid epidemic. It has among the highest rates of opioid overdose deaths and related morbidities in the nation. Its rural geography, culture of independence, strained economy and lack of access to substance use treatment have all contributed to the epidemic. Joining together University of Pittsburgh (Pitt), West Virginia University (WVU) and Penn State College of Medicine (PSU), the Appalachian Node will be led by experienced clinical investigators, Drs. Jane Liebschutz (Pitt) and Judith Feinberg (WVU). The node will bring together successful multi-disciplinary co-investigators, many of whom had prior CTN experience in other established nodes and who have been recruited to these institutions to respond to the regional substance use epidemic. The affiliated academic medical centers cover central and western Pennsylvania (PA) and all of West Virginia (WV) and have extensive bioinformatics databases with electronic health record and claims data. Use of a Stakeholder Advisory Group, support from regional payors, and close ties with state and local policy and public health officials will ensure that research has relevance and a high likelihood of sustainability after study completion. The three aims of the node are to: 1) conduct multisite trials that will address the current opioid crisis (and other substance misuse), with an emphasis on conducting studies among rural and other underserved populations, 2) propose studies to test innovative uses of existing resources (local pharmacies, peer navigators/peer recovery coaches, mobile technology, state-of-the-art health information systems) to implement evidence-based practices that will extend state-of-the-art care into resource-poor regions, both rural and urban, and 3) disseminate CTN findings to regional payers and policymakers, practitioners, and the community. The node will define local solutions to overcome the complex interplay of barriers in underserved rural and urban areas. The combination of our resources and those provided by the CTN will enable us to make a significant impact on the opioid epidemic in central Appalachia and nationally. Proposed studies built on work of node investigators include: 1) Serious Bacterial Infections Related to Injection Drug Use: Quality Metrics and Intervention (Liebschutz, Pollini), 2) Pharmacist-Assisted Buprenorphine Treatment (Winstanley), 3) Leveraging the Learning Health System to Incentivize Medication-Assisted Recovery for Opioid Use Disorder (Kraemer), and 4) An “Early Warning” System for Relapse Risk with Smartphone Apps and Wearable Devices (Kawasaki, Winstanley).

抽象的： NIDA 临床试验网络 (CTN) 的阿巴拉契亚节点将解决出现的临床研究问题来自阿巴拉契亚中部，是当前阿片类药物流行的中心，它是阿片类药物使用率最高的地区之一。该国的农村地理、独立文化紧张。经济和缺乏药物滥用治疗机会共同导致了这一流行病。匹兹堡大学 (Pitt)、西弗吉尼亚大学 (WVU) 和宾夕法尼亚州立大学医学院 (PSU) 阿巴拉契亚节点将由经验丰富的临床研究人员 Jane Liebschutz（皮特）和 Judith 博士领导。 Feinberg (WVU)。该节点将汇集成功的多学科联合研究人员，其中许多人都曾之前在其他已建立节点的 CTN 经验以及已被这些机构招募来应对的人员附属学术医疗中心覆盖中西部地区。宾夕法尼亚州 (PA) 和整个西弗吉尼亚州 (WV) 拥有广泛的生物信息学数据库和电子版使用利益相关者咨询小组、区域付款人的支持以及关闭与州和地方政策以及公共卫生官员的联系将确保研究具有相关性和高度研究完成后可持续性的可能性。该节点的三个目标是：1）进行多站点试验。这将解决当前的阿片类药物危机（和其他药物滥用），重点是进行研究在农村和其他服务不足的人群中，2) 提出研究来测试现有资源的创新用途（当地药房、同伴导航员/同伴康复教练、移动技术、最先进的健康信息系统）实施循证实践，将最先进的护理扩展到资源匮乏地区，农村和城市，以及 3) 将 CTN 调查结果传播给地区支付者和政策制定者、从业者和该节点将定义本地解决方案，以克服服务不足的障碍的复杂相互作用。我们的资源与 CTN 提供的资源的结合将使我们能够实现农村和城市地区的目标。对阿巴拉契亚中部和全国的阿片类药物流行产生重大影响基于工作的拟议研究。节点调查员包括： 1) 与注射毒品使用相关的严重细菌感染：质量指标和干预（Liebschutz、Pollini），2）药剂师辅助丁丙诺啡治疗（温斯坦利），3）利用学习健康系统激励阿片类药物使用障碍的药物辅助康复 (Kraemer)， 4) 针对智能手机应用程序和可穿戴设备复发风险的“早期预警”系统（川崎、温斯坦利）。