Methods for Selective Organic Synthesis based on Ionic Catalysts

基于离子催化剂的选择性有机合成方法

• 批准号: 10581216
• 负责人: F. Dean Toste
• 金额: $ 25万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-03 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10581216
• 关键词: Alkenes; Anions; Boronic Acids; Carbon; Catalysis; Complex; Data Science; Development; Fluorine; Goals; Gold; Halogens; Ligands; Methods; Modernization; Molecular; Organic Synthesis; Pharmaceutical Chemistry; Phosphoric Acids; Preparation; Process; Reaction; Research; Research Personnel; Role; Structure; Therapeutic; Transition Elements; base; catalyst; enantiomer; functional group; method development; programs; tool

Project Summary The major goal of this research program is to develop catalytic enantioselective transformations based on transition metal and chiral anion catalysis that will be broadly applicable to the preparation of therapeutically relevant organic molecules. Towards this end, new reactions for the enantioselective construction of C-O, C-N and C-halogen bonds are proposed. Particular emphasis is placed on the development of methods for the selective introduction of fluorine and fluorine-containing functional groups. Additionally, reactions that generate or employ available building blocks, such as alkenes and boronic acids, will be targeted. These methods will leverage new catalyst platforms, based on gold(III) complexes and phosphoric acid-based chiral anions, for the construction of fluorinated building blocks and heterocycles Additionally, the mechanistic underpinnings of these reactions will be studied, with a focus on uncovering the role of non-covalent interactions in achieving selectivity. Thus, we anticipate that this program will provide synthetic chemists and biomedical researchers with additional tools (reactions, catalysts, ligands etc.) for molecular synthesis and for single enantiomer construction, as well as provide principles for further development and application.

项目摘要 该研究计划的主要目标是开发催化对映选择性 基于过渡金属和手性阴离子催化的转化，这将是广泛的 适用于制备治疗相关的有机分子。走向这个 结束，C-O，C-N和C-卤代的对映选择性结构的新反应 提出了债券。特别强调的是开发的方法 选择性引入氟和含氟的官能团。 此外，产生或采用可用构件的反应，例如 烷烃和硼酸将被靶向。这些方法将利用新的催化剂 基于黄金（III）配合物和基于磷酸的手性阴离子的平台，用于 建造氟化的构件和杂环，此外 将研究这些反应的机械基础，重点是 揭示了非共价相互作用在达到选择性中的作用。因此，我们 预计该计划将为合成化学家和生物医学研究人员提供 使用其他工具（反应，催化剂，配体等）进行分子合成和用于 单一对映异构体的结构，并提供了进一步发展的原则 和应用。