Black Male Brain Reserve, Resilience & Alzheimer’s Disease: Life Course Perspectives

黑人男性大脑储备、恢复能力

基本信息

批准号：
10577890
负责人：
Maria C Carrillo
金额：
$ 4.98万
依托单位：
GEORGE WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-15 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10577890
关键词：
Address Adult African American Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Applications Grants Athletic Attention Attitude Award Awareness Behavioral Behavioral Sciences Belief Biological Biomedical Research Black American Black race Brain Cardiac Cognitive Cognitive aging Communities Consultations County Dedications Development Diabetes Mellitus Disease Disparity Documentation Elderly Environmental Exposure Evaluation Family Feedback Fellowship Foundations Future Gender Goals Health Health Disparities Research Health Sciences Health Status Hypertension Individual Institution Investments Knowledge Leadership Learning Life Cycle Stages Life Expectancy Longevity Manufactured football Manuscripts Mental Depression Mental Health Mentors Michigan Modeling Morbidity - disease rate Not Hispanic or Latino Outcome Personal Satisfaction Population Predisposition Prevalence Public Health Publishing Recommendation Registries Research Research Personnel Research Project Grants Resources Risk Risk Factors Science Scientific Advances and Accomplishments Scientist Series Site Societies Training Translating Translational Research Traumatic Brain Injury Underrepresented Populations United States Work aging brain base behavioral health black men black women brain health cardiovascular health cognitive reserve community engagement cultural competence dementia care dementia risk design disparity elimination effective intervention experience falls health care service utilization health disparity health equity health organization improved innovation male male health meetings member multidisciplinary psychologic recruit resilience resilience factor retention rate social social adversity social culture symposium volunteer

项目摘要

Project Summary/Abstract: The United States has invested significant resources through innovative research to address the profound effects of Alzheimer’s Disease, and Alzheimer’s Disease and Related Dementias (AD/ADRD) on families and society, but Black males historically have not experienced the full benefits of scientific advances from that research. For example, non-Hispanic Black men have diminished health and increased morbidity due to preventable diseases (e.g., cardiac, diabetes, high blood pressure) and shorter life expectancies than their White male counterparts Additionally, elderly Black men are more likely to fall and sustain a TBI than whites, which increases the subsequent vulnerability of the brain and risk of dementia. Although the prevalence of Alzheimer’s disease in Black Americans is two to three times higher than Whites, a complete understanding of the cause of this health disparity remains elusive. The lack of a highly trained, multidisciplinary scientific workforce that addresses the full range of biological, biomedical, behavioral, and health sciences approaches to AD/ADRD health disparities research hinders innovation among this population. This problem is compounded by the persistent under- representation of Black American males in biomedical. During this three-year conference series, leading multidisciplinary scholars will come together with emerging investigators from across the U.S. to address specific cultural, social and behavioral factors that contribute to some individuals in this population being more cognitively resilient and experience a reduced risk of developing Alzheimer’s disease than others. Scholars will enhance the NIA Health Disparities Research Framework (HDRF) with the inclusion of empirically based factors that are responsive to the Black male experience, as well as focus on efforts to improve recruitment and retention strategies for participation from this population in aging research. An essential feature of the conference series will be to engage community stakeholders (e.g., NFL Alumni Association, Men’s Health Network, Pinellas County Health Department) in multiple aspects of the conference design, planning and implementation including the selection of scientists, providing feedback on conference presentations, and dissemination. Planning, implementation, participation and evaluation of the conference will incorporate individuals from historically underrepresented groups The aims of the conference series are: (1) to address knowledge gaps and identify future priorities in cognitive reserve, resilience, and AD/ADRD health disparities life course research among Black males; (2) to cultivate a culturally competent workforce trained and committed to addressing Black male’s brain health, cognitive aging, and AD/ADRD research, (3) build a multisite research volunteer registry of Black males. These initiatives help support important work that align with the goals of the Division of Behavioral Health and Society Research (BSR) within NIA, to achieve health equity, eliminate disparities, and improve the health of all groups.

项目摘要/摘要：美国通过创新研究投入了大量资源来解决其深远影响阿尔茨海默病以及阿尔茨海默病和相关痴呆症 (AD/ADRD) 对家庭和社会的影响，但从历史上看，黑人男性并没有从这项研究中体验到科学进步的全部好处。例如，非西班牙裔黑人男性由于可预防的疾病而健康状况恶化，发病率增加（例如心脏病、糖尿病、高血压），预期寿命比白人男性同行短此外，老年黑人比白人更容易摔倒并遭受创伤性脑损伤，这增加了尽管阿尔茨海默病在中国很流行，但随后大脑的脆弱性和痴呆的风险。美国黑人比白人高两到三倍，彻底了解这种健康的原因缺乏训练有素的多学科科学队伍来解决这一问题。针对 AD/ADRD 健康差异的全方位生物学、生物医学、行为和健康科学方法研究阻碍了这一群体的创新，这个问题因持续的不足而变得更加复杂。在这个为期三年的会议系列中，美国黑人男性的代表性。多学科学者将与来自美国各地的新兴研究人员聚集在一起解决特定的文化、社会和行为因素导致该人群中的某些人更加与其他学者相比，他们的认知能力更强，患阿尔茨海默病的风险也更低。加强 NIA 健康差异研究框架 (HDRF)，纳入基于经验的研究对黑人男性经历做出反应的因素，以及重点努力改善招聘和保留这一人群参与老龄化研究的策略。系列会议将吸引社区利益相关者（例如 NFL 校友会、男性健康协会）网络、皮尼拉斯县卫生局）在会议设计、策划和多个方面进行了实施，包括选择科学家、提供会议报告反馈，以及会议的规划、实施、参与和评估将包括在内。来自历史上代表性不足群体的个人该系列会议的目的是：(1) 解决知识差距并确定认知储备、复原力和 AD/ADRD 健康差异方面的未来优先事项黑人男性的生命历程研究；（2）培养一支经过培训和培训的具有文化能力的劳动力队伍；致力于解决黑人男性的大脑健康、认知衰老和 AD/ADRD 研究，(3) 建立这些举措有助于支持重要的黑人男性研究志愿者登记。遵循 NIA 行为健康与社会研究部 (BSR) 的目标，实现健康公平，消除差距，改善所有群体的健康。