Challenging Allergies: The Search for a Magic Bullet for Pediatric Food Allergies

挑战过敏：寻找治疗儿童食物过敏的灵丹妙药

• 批准号: 10578414
• 负责人: JILL A FISHER
• 金额: $ 4.95万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-12 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10578414
• 关键词: Accidents; Adolescent; Advocate; Affect; Allergens; Allergic; Allergy to peanuts; American; Benefits and Risks; Biomedical Research; Black race; Books; Cessation of life; Child; Childhood; Clinic; Clinical Trials; Data; Development; Empirical Research; Enrollment; Ethnic Population; Ethnography; Family; Food; Food Hypersensitivity; Funding; Grant; Guidelines; Health; Hypersensitivity; Interview; Investments; Life; Literature; Low income; Magic; Manuscripts; Marketing; Medical; Modeling; Parents; Pathway interactions; Patients; Perception; Pharmaceutical Preparations; Pharmacologic Substance; Powder dose form; Private Practice; Privatization; Protocols documentation; Public Health; Qualifying; Quality of life; Reaction; Reporter; Research; Research Personnel; Risk; Safety; Sales; Sampling; Social Sciences; Stress; Structure; Therapeutic; Therapeutic Intervention; Treatment/Psychosocial Effects; Underrepresented Minority; United States; United States Food and Drug Administration; United States National Institutes of Health; Work; Writing; aged; clinical practice; effective therapy; experience; food allergen; food avoidance; innovation; interest; lens; novel therapeutics; racial population; recruit; research and development; risk perception; treatment comparison; urban area

PROJECT SUMMARY This project proposes empirical research and a scholarly book on the medicalization and pharmaceuti- calization of food allergies. One out of every 13 US children has a food allergy, and nearly half of those children are allergic to multiple foods. Because food allergies can be life-threatening, a significant amount of biomedical research and development has been invested in finding effective therapies. These novel therapeutic options—including one recent FDA-approved drug, an array of clinical trials, and even un- regulated food-based treatments—have attracted considerable parental interest despite potentially sig- nificant risks. Indeed, preliminary research indicates that parents often have a higher tolerance for the risks of these medical treatments compared to the risks from food. I am currently completing an ethnographic study of peanut allergy clinical trials, and the proposed project will expand and continue this line of research for the scholarly book through three specific aims: (1) ex- plore the experiences and perceptions of parents of children with peanut or other food allergies who have not pursued clinical trials, (2) document how unregulated food allergy treatments are being offered through private practices, and (3) integrate empirical findings from Aims 1 & 2 with my current ethno- graphic work on food allergy clinical trial participation. For Aim 1, I will conduct 30 interviews with par- ents who are (a) practicing avoidance of their children's food allergens with no additional treatment, (b) treating their children's peanut allergy with the FDA-approved drug, or (c) treating their children's food allergies with unregulated therapies. For Aim 2, I will conduct 10 interviews with clinicians who offer unregulated food-based treatments for food allergies to analyze how they describe their practices, includ- ing any safety protocols they have in place. The book manuscript will be written as part of Aim 3, wherein I will use data from both projects to provide a comprehensive view of food allergy therapeutics. The proposed project is significant because it will provide rich information about how US families navi- gate food allergies as a part of everyday life as well as a condition that increasingly justifies risky thera- peutic interventions. This project is innovative because food allergy therapeutics have not been examined from a critical social science perspective, and there has been no empirical research comparing the per- spectives of parents who choose different medical pathways to manage their children's food allergies or comparing how stakeholders perceive potential differences between FDA-approved, investigational, and unregulated food allergy treatments. Food allergies are certainly a health threat, but this new era of food allergy therapeutics marks a transition in which the condition is being more intensely and problematically medicalized.

项目摘要 该项目提出了实证研究和一本有关医疗和制药的科学书籍 食物过敏的平静。每13个孩子中，有一个有过敏性过敏，几乎一半 儿童对多种食物过敏。因为食物过敏可能会危及生命，所以大量 生物医学研究和开发已投资用于寻找有效的疗法。这些小说 治疗选择 - 包括最近的FDA批准药物，一系列临床试验，甚至没有 - 受管制的食物治疗 - 吸引了相当大的父母利益所需的偏好潜在的偏爱 巨大的风险。确实，初步研究表明，父母对 与食物的风险相比，这些医疗治疗的风险。 我目前正在完成一项关于花生过敏临床试验的民族志研究，拟议项目 将通过三个特定目标扩展并继续为科学书籍扩展并继续研究：（1） 在患有花生或其他食物过敏的孩子的父母的经历和看法 未进行临床试验，（2）记录如何提供不受监管的食物过敏治疗 通过私人实践，以及（3）AIM 1和2的综合经验发现与我当前的民族 食物过敏临床试验的图形工作。对于AIM 1，我将对PAR进行30次访谈 （a）练习​​避免儿童食物过敏原而没有其他治疗的人，（b） 用FDA批准的药物治疗孩子的花生过敏，或（c）治疗孩子的食物 疗法不受管制的过敏。对于AIM 2，我将对提供的临床医生进行10次访谈 基于食物过敏的不受管制的食物治疗方法分析了它们如何描述其做法，包括 - 制定他们已经制定的任何安全协议。这本书手稿将写为AIM 3的一部分，其中 我将使用两个项目的数据来提供食物过敏疗法的全面视图。 拟议的项目很重要，因为它将提供有关美国家庭如何导航的丰富信息 门户过敏作为日常生活的一部分，以及增加风险有理由的状况 精力干预措施。该项目具有创新性，因为尚未检查食物过敏疗法 从批判的社会科学角度来看，没有经验研究比较 父母的观察者选择不同的医疗途径来管理孩子的食物过敏或 比较利益相关者如何看待FDA批准，研究和 不受管制的食物过敏治疗。食物过敏肯定是健康的威胁，但是这个新时代的食物时代 过敏疗法标志着这种状况更为积极和有问题的过渡 医疗。