2021 and 2023 Alcohol-Induced End Organ Diseases Gordon Research Conference

2021 年和 2023 年酒精引起的终末器官疾病戈登研究会议

基本信息

批准号：
10574538
负责人：
ELIZABETH J. KOVACS
金额：
$ 2.5万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-20 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10574538
关键词：
Acceleration Acute Address Alcohol abuse Alcohol consumption Alcoholic Liver Diseases Alcohols Area Arrhythmia Automobile Driving Breast Cells Chronic Clinical Investigator Collaborations Colon Communities Development Diabetes Mellitus Diagnosis Discipline Disease Drug abuse Economic Burden Ensure Environment Epidemic Etiology Fetal Alcohol Syndrome Formulation Fostering Future Future Generations Goals Health Height Hypertension Immunologics Individual Injury International Knowledge Lead Liver Longevity Malignant Neoplasms Metabolic syndrome Methodology Modeling Molecular Morbidity - disease rate Myocardial Ischemia Obesity Organ Osteoporosis Pancreatitis Pathway interactions Pneumonia Postdoctoral Fellow Prevention Research Research Personnel Risk Scientific Advances and Accomplishments Shapes Societies Stroke Structure Techniques Time Tissues Underrepresented Minority Upper respiratory tract Work alcohol abuse therapy alcohol effect alcohol exposure alcohol misuse alcohol research alcohol use disorder body system career experience insight meetings minority scientist mortality next generation novel strategies organ injury organ repair peer posters pre-clinical prevent repaired research and development student participation symposium synergism therapeutic development therapeutically effective tissue injury unpublished works

项目摘要

Abstract Alcohol misuse is one of the world's leading preventable health risks. Alcohol use and abuse is a causal factor in over 60 different diseases and injuries putting an enormous health and economic burden on societies worldwide. The major share of alcohol-induced morbidity and mortality is attributable to alcohol-induced end organ diseases, including cancer, alcoholic liver disease, pancreatitis, osteoporosis, diabetes mellitus, hypertension, ischemic heart disease, arrhythmias, stroke, pneumonia and fetal alcohol syndrome. Alcohol use disorders are on the rise in all segments of society and they often synergize with other diseases that have reached epidemic proportions including obesity, diabetes, metabolic syndrome, drug abuse and immunological maladies. Despite the significant advances of the field over the last two decades, the underlying disease etiology is poorly understood and there is an urgent need to gain new knowledge of the molecular underpinnings of alcohol-induced end organ diseases to accelerate diagnosis, prevention, and treatment. In this R13 application, we are seeking support for the Gordon Research Conferences (GRC) Alcohol-induced End Organ Diseases 2021 and 2023. This is a relatively new GRC, which was initiated three years ago held extremely successful meetings in 2017 and 2019. The open format of GRC model includes sharing significant unpublished work and provides ample opportunities for in-depth discussions with peers, new colleagues and the future generation of alcohol researchers; this conference model is ideally suited for propelling the field to new heights. The overall goal of the Alcohol-induced End Organ Diseases meetings are to foster open discussion of research developments, establish new scientific collaborations, and propel the next generation of scientific advances. This GRC fills a critical need in the field for a continuing meeting that presents key recent findings on alcohol-induced end organ injury and repair in a unique format that ensures time for in-depth discussions, formulation of new approaches and initiation of new collaborations. This conference will 1) provide a forum that promotes open discussion of cutting edge research at the forefront of alcohol-induced tissue injury, 2) foster the development of the next generation of alcohol and tissue injury investigators, 3) promote interaction between young and senior investigators, 4) facilitate the exchange of ideas that will shape the future directions of the alcohol and tissue injury community and 5) introduce breakthrough techniques that facilitate the understanding of mechanisms driving alcohol-induced tissue injuries. We envision the GRC on “Alcohol induced end organ diseases” will significantly advance current understanding of the underlying mechanisms of end organ injuries and stimulate development of effective therapeutic strategies for the diagnosis, prevention and treatment of alcohol use disorders.

抽象的酒精滥用是世界上主要的可预防健康风险之一，酒精的使用和滥用是一个致病因素。 60 多种不同的疾病和伤害给社会带来巨大的健康和经济负担世界范围内，酒精引起的发病率和死亡率的主要部分是由酒精引起的。器官疾病，包括癌症、酒精性肝病、胰腺炎、骨质疏松症、糖尿病、高血压、缺血性心脏病、心律失常、中风、肺炎和胎儿酒精综合症。社会各阶层的疾病呈上升趋势，并且常常与其他疾病产生协同作用。达到流行病的程度，包括肥胖、糖尿病、代谢综合征、药物滥用和免疫学尽管该领域在过去二十年取得了重大进展，但潜在的疾病。病因学知之甚少，迫切需要获得分子生物学的新知识酒精引起的终末器官疾病的基础，以加速诊断、预防和治疗。在此 R13 应用程序中，我们正在寻求对戈登研究会议 (GRC) 酒精诱导的支持 2021 年和 2023 年终末器官疾病。这是一个相对较新的 GRC，于三年前发起并举行 2017年和2019年的会议非常成功。GRC模型的开放格式包括重要的分享未发表的工作，并提供充足的机会与同行、新同事和未来一代的酒精研究人员；这种会议模式非常适合推动该领域的发展酒精引起的终末器官疾病会议的总体目标是促进开放。讨论研究进展，建立新的科学合作，并推动下一代此次 GRC 满足了该领域对持续召开会议的迫切需求，该会议展示了近期的关键进展。以独特的形式研究酒精引起的终末器官损伤和修复，确保有时间进行深入研究本次会议将 1) 提供讨论、制定新方法和启动新合作。促进酒精诱导组织前沿研究公开讨论的论坛损伤，2) 培养下一代酒精和组织损伤研究人员的发展，3) 促进年轻和资深研究人员之间的互动，4）促进塑造未来的思想交流酒精和组织损伤界的方向，5）引入突破性技术，促进我们设想 GRC 的主题是“酒精”。诱发的终末器官疾病”将显着推进目前对潜在机制的理解终末器官损伤并刺激开发有效的诊断、预防治疗策略和酒精使用障碍的治疗。