CLINICAL TRIAL: EFFECT OF GROWTH HORMONE TREATMENT ON RECOVERY FROM CUSHING'S DI

临床试验：生长激素治疗对库欣病康复的影响

• 批准号: 7718544
• 负责人: MARY L VANCE
• 金额: $ 4.65万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718544
• 关键词: Adrenal Glands; Aftercare; Benign; Body Composition; Bone Density; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Excision; Exercise; Fatty acid glycerol esters; Funding; Grant; High Blood Pressure; Hydrocortisone; Institution; Measures; Mental Depression; Metabolism; Muscle; Operative Surgical Procedures; Osteoporosis; Patients; Pituitary Gland; Pituitary Neoplasms; Pituitary-dependent Cushing' s disease; Placebos; Production; Purpose; Quality of life; Randomized; Rate; Recovery; Research; Research Personnel; Resources; Somatotropin; Source; United States National Institutes of Health; Weight Gain; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cushing's disease is excessive cortisol production caused by a benign tumor in the pituitary gland that stimulates the adrenal glands to produce too much cortisol causing weight gain, diabetes, high blood pressure, osteoporosis and depression in many patients. After successful removal of the pituitary tumor, recovery from Cushing's is often prolonged, usually at least one year. The purpose of this study is to determine if 1 or 2 years of growth hormone treatment after successful pituitary surgery accelerates the rate of recovery. The study involves the study of body composition (fat mass, muscle mass, bone density), exercise strength, metabolism and quality of life measures. Patients are randomized to receive either 1 or 2 years of growth hormone treatment to compare the rate of natural recovery with growth hormone treatment during the first year and the second year. Two thirds of patients receive growth hormone and one third of patients receive placebo during the first year; during the seond year, all patients receive growth hormone.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 库欣病是由垂体良性肿瘤引起的皮质醇产生过多，刺激肾上腺产生过多的皮质醇，导致许多患者体重增加、糖尿病、高血压、骨质疏松症和抑郁症。 成功切除垂体瘤后，库欣氏病的恢复时间通常会延长，通常至少一年。 本研究的目的是确定成功垂体手术后 1 或 2 年的生长激素治疗是否可以加快康复速度。 该研究涉及身体成分（脂肪量、肌肉量、骨密度）、运动强度、新陈代谢和生活质量指标的研究。 患者被随机接受 1 年或 2 年的生长激素治疗，以比较第一年和第二年的自然恢复率与生长激素治疗。 三分之二的患者在第一年接受生长激素治疗，三分之一的患者接受安慰剂治疗；在第二年，所有患者都接受生长激素。