Systems Biology of Early Atopy (SUNBEAM) Analysis and Bioinformatics Center

早期特应性系统生物学（SUNBEAM）分析和生物信息学中心

• 批准号: 10573523
• 负责人: Supinda Bunyavanich
• 金额: $ 364.99万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-08 至 2027-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10573523
• 关键词: Adult; Affect; Allergic; Allergic Disease; Anaphylaxis; Angioneurotic Edema; Area; Atopic Dermatitis; Award; Bioinformatics; Biological; Biological Assay; Biological Markers; Biology; Birth; Cardiovascular system; Child; Chronic; Clinical; Clinical Management; Cohort Studies; Collection; Communication; Complex; Computational Biology; Data; Data Science; Development; Diagnosis; Dimensions; Disease; Distress; Emotional; Enrollment; Ensure; Fathers; Food; Food Hypersensitivity; Funding; Future; General Population; Genetic; Genome; Goals; Health; Hypersensitivity; Immune; Immunologist; Impairment; Individual; Infrastructure; Ingestion; Intervention; Knowledge; Life; Molecular; National Institute of Allergy and Infectious Disease; Participant; Phenotype; Physicians; Policies; Pregnant Women; Prevention; Procedures; Proteome; Quality of life; Research; Research Activity; Research Personnel; Risk; Risk Factors; Role; Scientist; Skin; Symptoms; System; Systems Biology; Technology; Time; United States National Institutes of Health; Urticaria; Visualization; atopy; biobank; biological heterogeneity; biological systems; cohort; data integration; design; expectation; experience; food antigen; gastrointestinal; high dimensionality; improved; innovation; lipidome; machine learning model; metabolome; microbiome; multiple omics; multiscale data; novel; novel marker; nutrition; respiratory; risk sharing; success; tool; transcriptome; whole genome

PROJECT SUMMARY Food allergy (FA) and atopic dermatitis (AD) are common chronic conditions of atopy affecting 10% and 20% of children, respectively. Individuals with FA are at daily risk for potentially life-threatening hives, angioedema, respiratory difficulty, cardiovascular compromise, gastrointestinal distress, and/or anaphylaxis following ingestion of a food antigen to which they are sensitized. Individuals with AD must live with chronically pruritic, inflamed skin that can cover a significant proportion of their bodies and become infected. The development of FA is frequently preceded by AD, suggesting shared risk factors and overlapping pathobiology. FA and AD are complex diseases, and parsing the biological heterogeneity hidden under their clinical umbrellas is paramount to improving their prevention, diagnosis, and clinical management. A systems biology approach where the biology of FA and AD are investigated comprehensively at several levels may help identify new knowledge about the development of allergy. Systems Biology of Early Atopy (SunBEAm) is a general population pre-birth cohort study initiated by the NIAID to study the role and inter-relationships of genetic, clinical, biological, and environmental early-life factors in the development of allergic diseases, with an emphasis on FA and AD. Pregnant women, children born to them, and the children's biological fathers are being enrolled and phenotyped with longitudinal biosample collections. A central goal of SunBEAm is to apply systems biology to identify mechanisms and biomarkers underlying the development of FA, AD, and their endotypes. The overarching goal of this SunBEAm Analysis & Bioinformatics Center (ABC) application is to create a center for assaying SunBEAm biosamples using omics, and to apply integrative systems biology to identify novel determinants of FA and AD. Our application centers on these five specific aims: (1) Assay biosamples from SunBEAm participants to generate longitudinal, multi-scale omic data that will inform on the development of FA and AD; (2) Analyze the systems-wide omic data generated to identify novel biomarkers, endotypes, and mechanisms underlying the development of FA and AD; (3) Integrate data across molecular dimensions to identify key drivers and predictors of FA and AD development; (4) Share all generated data, create a centralized platform for SunBEAm data and bioinformatic innovations, and build capacity for the integration of future SunBEAm omics data; and (5) Develop infrastructure for interactions with the SunBEAm Steering Group, the NIAID Statistical and Clinical Coordinating Center, and NIAID. With this award, we will create a center for unprecedented systems allergy research. In addition to an investigator team with world- class expertise in multi-omics, systems biology, computational biology, data science, and bioinformatics, our team also includes physician-scientists and immunologists who directly designed and continue to actively drive the ongoing enrollment and implementation of SunBEAm. Our team's experience, expertise, and proven track record will ensure the success of SunBEAm-ABC.

项目摘要 食物过敏（FA）和特应性皮炎（AD）是特应性的常见慢性疾病，影响10％和20％ 分别为儿童。 FA患者每天都有潜在威胁生命的蜂箱，血管性水肿的风险 呼吸困难，心血管折衷，胃肠道遇险和/或过敏反应 摄取对其敏感的食物抗原。患有广告的人必须与长期熟练的人生活在一起， 发炎的皮肤可覆盖其大部分身体并感染的皮肤。发展的发展 FA经常先于AD之前，提示共同的风险因素和重叠的病理生物学。 FA和AD是 复杂的疾病，解析隐藏在其临床雨伞下的生物异质性至关重要 改善其预防，诊断和临床管理。系统生物学方法 FA和AD的生物学在多个层面上进行了全面研究，可能有助于确定新知识 关于过敏的发展。早期特应二（Sunbeam）的系统生物学是普通人群 NIAID发起的队列研究研究了遗传，临床，生物学和 环境早期生活因素在过敏性疾病发展中，重点是FA和AD。 孕妇，她们出生的孩子，以及孩子们的生物父亲正在招收， 用纵向生物样品集合表型。 Sunbeam的一个核心目标是将系统生物学应用于 确定FA，AD及其内型开发的基础机制和生物标志物。这 这个Sunbeam分析与生物信息学中心（ABC）应用程序的总体目标是创建一个 使用OMICS测定Sunbeam生物样本的中心，并将集成系统生物学应用于 确定FA和AD的新型决定因素。我们的申请中心以这五个特定目的为中心：（1）测定 来自Sunbeam参与者的生物样本生成纵向多尺度的OMIC数据，这些数据将告知 FA和AD的开发； （2）分析为识别新型生物标志物而生成的全系统的OMIC数据， 内型和FA和AD发展的基础机制； （3）整合分子的数据 确定FA和AD开发的关键驱动因素和预测因素的维度； （4）共享所有生成的数据， 创建一个集中式平台，用于日光数据和生物信息学创新，并为 将来的Sunbeam Omics数据集成； （5）开发与Sunbeam相互作用的基础设施 转向组，NIAID统计和临床协调中心以及NIAID。有了这个奖项，我们将 为前所未有的系统过敏研究创建一个中心。除了世界的调查员团队 - 多词，系统生物学，计算生物学，数据科学和生物信息学方面的班级专业知识，我们 团队还包括直接设计并继续积极驾驶的医师科学家和免疫学家 阳光的持续入学和实施。我们团队的经验，专业知识和经过验证的轨道 记录将确保Sunbeam-ABC的成功。