Characterizing parental beliefs to support optimization of vaccine introduction

描述父母的信念以支持疫苗引入的优化

基本信息

批准号：
10571859
负责人：
Abram Luther Wagner
金额：
$ 9.25万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-12-01 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10571859
关键词：
Acute Disease Adolescent Adoption Advisory Committees Affect Age Applications Grants Attitude Award Belief COVID-19 pandemic Centers for Disease Control and Prevention (U.S.)Characteristics Chickenpox Child Childhood China Chinese Chronic Disease Communicable Diseases Communication Complex Country Data Decision Making Dimensions Disease Education Environment Epidemiologist Epidemiology Funding Future Goals Government Grant Haemophilus influenzae type b Health Health Policy Healthcare Human Papilloma Virus Vaccination Human Papilloma Virus Vaccine Human Papillomavirus Immunization Immunization Programs Incidence Income Individual Infant International Intervention Knowledge Licensing Malignant Neoplasms Marketing Mentors Methodology Methods Michigan Parents Perception Persons Physicians Policies Population Positioning Attribute Privatization Provider Public Health Recommendation Regimen Research Research Personnel Respiratory Tract Infections Risk Sampling Second Primary Cancers Secondary to Sexual Transmission Sexually Transmitted Diseases Surveys Time Training Training Programs Trust Universities Use Effectiveness Vaccination Vaccines Work World Health Organization acute infection base cancer prevention disorder risk distrust effectiveness testing experience implementation science improved mid-career faculty novel vaccines preference prevent professor programs risk perception sex skills uptake vaccine acceptance vaccine access vaccine distribution vaccine hesitancy willingness

项目摘要

The number of vaccines recommended by the World Health Organization for every country to include in government-sponsored childhood vaccination programs has rapidly increased over the past fifteen years, although there is little research regarding the best approach to new vaccine introduction into a population that may be unfamiliar with the specific disease prevented. However, the circumstances surrounding the initial rollout of a vaccine may exert a lasting impact on perceptions of the vaccine and the disease prevented (e.g., human papillomavirus (HPV) vaccine uptake is extremely low more than ten years after its introduction in the US). This mentored training program will build upon my strong educational base in epidemiology, and will help me develop skills in decision and implementation sciences to reach my long-term goals: to understand how attitudes towards vaccines change over time as more vaccines become available; and to develop interventions that can effectively minimize distrust when a vaccine is newly introduced into a population. The training program in this grant will familiarize me with relevant methodological approaches; I will gain expertise in (1) developing health messages, (2) researching people's preferences for health care interventions, (3) understanding governmental perspectives on vaccine adoption, and (4) managing complex international studies. The research goal of this proposal utilizes this training regimen to characterize how the inherent characteristics of a vaccine-preventable disease (as presented during vaccine introduction) affect the valuation of a specific vaccine and the entire vaccination program. Specifically, I will (1) determine changes in vaccination in Shanghai and Michigan over the course of the COVID-19 pandemic, (2) characterize preferences for vaccine profile and vaccination program attributes during vaccine introduction, (3) identify problems in the introduction of vaccines for sexually transmitted infections in a population. This proposal will generate pilot data to support a future R01 grant, which will test the effectiveness of systemic- and provider-level activities and interventions on the uptake of HPV vaccine while also aiming to reduce vaccine hesitancy. Ideally, the adoption of new vaccines in China accompanying the expansion of their government sponsored childhood vaccination program can avoid the pitfalls experienced in other countries with new vaccine introduction, and in turn inform vaccine introduction strategies in the US. This grant proposal is supported by an advisory team comprising Dr. Matthew Boulton-a physician-epidemiologist with expertise in childhood immunization; Professor Lisa Prosser-an interdisciplinary health policy researcher with a research focus on vaccine decision-making; Professor Brian Zikmund-Fisher-a leader in health messaging and risk communication; Dr. Xiaodong Sun-the Director of Immunization Programs at the Shanghai Centers for Disease Control and Prevention; and Dr. Yihan Lu-an Associate Professor of Epidemiology at Fudan University in Shanghai, China

世界卫生组织建议每个国家纳入政府资助的儿童疫苗接种计划的疫苗数量在过去 15 年中迅速增加，尽管关于向可能需要接种疫苗的人群引入新疫苗的最佳方法的研究很少。不熟悉所预防的具体疾病。然而，疫苗最初推出的环境可能会对疫苗和所预防疾病的看法产生持久影响（例如，人乳头瘤病毒 (HPV) 疫苗在美国推出十多年后的使用率极低）。这项指导培训计划将建立在我强大的流行病学教育基础之上，并将帮助我发展决策和实施科学方面的技能，以实现我的长期目标：了解随着更多疫苗的出现，人们对疫苗的态度如何变化；并制定干预措施，有效减少新疫苗引入人群时的不信任。这笔赠款中的培训计划将使我熟悉相关的方法论；我将获得以下方面的专业知识：(1) 制定健康信息；(2) 研究人们对医疗保健干预措施的偏好；(3) 了解政府对疫苗采用的看法；以及 (4) 管理复杂的国际研究。该提案的研究目标是利用这种训练方案来描述疫苗可预防疾病的固有特征（如疫苗引入过程中所呈现的）如何影响特定疫苗和整个疫苗接种计划的评估。具体来说，我将 (1) 确定在 COVID-19 大流行期间上海和密歇根州疫苗接种的变化，(2) 描述疫苗引进过程中对疫苗概况和疫苗接种计划属性的偏好，(3) 找出引进疫苗过程中的问题针对人群中性传播感染的疫苗。该提案将生成试点数据来支持未来的 R01 拨款，该拨款将测试系统和提供者层面的活动和干预措施对 HPV 疫苗的使用的有效性，同时也旨在减少疫苗犹豫。理想情况下，中国采用新疫苗并扩大政府资助的儿童疫苗接种计划，可以避免其他国家引进新疫苗时遇到的陷阱，从而为美国的疫苗引进策略提供参考。这项拨款提案得到了顾问团队的支持，该团队由 Matthew Boulton 博士组成，他是一位在儿童免疫方面具有专业知识的医生兼流行病学家； Lisa Prosser教授——跨学科卫生政策研究员，研究重点是疫苗决策； Brian Zikmund-Fisher 教授——健康信息传递和风险沟通领域的领导者；孙晓东博士——上海市疾病预防控制中心免疫项目主任；和中国上海复旦大学流行病学副教授陆一涵博士

项目成果

期刊论文数量（25）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Vaccine hesitancy and receipt of mandatory and optional pediatric vaccines in Shanghai, China.

DOI：
10.1080/21645515.2022.2043025
发表时间：
2022-11-30
期刊：
Human vaccines & immunotherapeutics
影响因子：
4.8
作者：
通讯作者：

The association of religion with maternal and child health outcomes in South Asian countries.

DOI：
10.1371/journal.pone.0271165
发表时间：
2022
期刊：
PloS one
影响因子：
3.7
作者：
通讯作者：

The Relationship Between Influenza and COVID-19 Vaccine Uptake in a Cross-Sectional Study in China, Indonesia, Malaysia, and the United States.

中国、印度尼西亚、马来西亚和美国的一项横断面研究中流感与 COVID-19 疫苗接种之间的关系。

DOI：
10.1177/10105395231171957
发表时间：
2023
期刊：
Asia-Pacific journal of public health
影响因子：
2.5
作者：
Zhang,Felicia;Harapan,Harapan;Rajamoorthy,Yogambigai;Lu,Yihan;Wagner,AbramL
通讯作者：
Wagner,AbramL

Vaccine Hesitancy and Rejection of a Vaccine for the Novel Coronavirus in the United States.

DOI：
10.3389/fimmu.2021.558270
发表时间：
2021
期刊：
Frontiers in immunology
影响因子：
7.3
作者：
Shih SF;Wagner AL;Masters NB;Prosser LA;Lu Y;Zikmund-Fisher BJ
通讯作者：
Zikmund-Fisher BJ

Experiences, risk perceptions, and COVID-19 vaccination outcomes among hospital workers.

DOI：
10.1016/j.vaccine.2023.01.012
发表时间：
2023-02-03
期刊：
VACCINE
影响因子：
5.5
作者：
Wagner, Abram L.;Moniz, Michelle H.;Stout, Molly J.;Townsel, Courtney;Hawley, Sarah T.;Zikmund-Fisher, Brian J.
通讯作者：
Zikmund-Fisher, Brian J.