A Synchrotron Radiation Structural Biology Resource

同步辐射结构生物学资源

基本信息

批准号：
10579751
负责人：
KEITH O HODGSON
金额：
$ 26.59万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10579751
关键词：
Area Automation Biological Biomedical Research Clinic Collaborations Communities Complement Computer software Cryoelectron Microscopy Crystallography Data Data Analyses Data Collection Detection Development Education and Outreach Educational workshop Facility Accesses Funding Generations Goals Grant Health Human Image Imaging Device Individual Instruction Investments Laboratories Leadership Life Light Measurement Membrane Lipids Mentors Methodology Methods Molecular Biology National Institute of General Medical Sciences Peer Review Performance Privatization Process Productivity Recording of previous events Research Research Personnel Research Project Grants Resources Roentgen Rays Schools Science Services Site Source Spectrum Analysis Structure Synchrotrons Techniques Technology Time Training Training Programs Training Support United States National Institutes of Health Work X ray spectroscopy X-Ray Crystallography absorption base biological systems computer cluster computerized data processing data quality detector experience experimental study flexibility human disease innovation instrument instrumentation new technology novel therapeutics online resource operation outreach outreach program programs ranpirnase spectroscopic imaging structural biology success synchrotron radiation technological innovation theories tool web portal web-based tool x-ray free-electron laser

项目摘要

Summary/Abstract - P30GM133894 Synchrotron radiation (SR) is an extremely bright and tunable x-ray source that enables forefront research in structural molecular biology (SMB). The goal of “A Synchrotron Structural Biology Resource" at the Stanford Synchrotron Radiation Lightsource (SSRL), hereafter referred to as simply “Resource”, is to provide users access to integrated, mature SMB capabilities utilizing state-of-the-art synchrotron beam line facilities for macromolecular crystallography, x-ray absorption/emission/imaging spectroscopy and small angle x-ray scattering/diffraction. These three areas comprise the Resource’s three Technical Operations Cores. Special emphasis is to create streamlined user access, provide dedicated user support and services, to train users, and to perform outreach on the scientific benefits of the capabilities of these specialized, yet mature facilities to the biomedical research community. Multiple innovative access mechanisms are being provided, that include both single- and multiple-technique approaches to access the Cores, based on a transparent and robust external peer-review process. A multifaceted training and outreach program includes individual training, workshops, summer schools, on-the-road, and support clinic segments by experienced scientific and technical staff. A Resource web portal provides streamlined scientific, technical, training, outreach and administrative material and other relevant information. A principal aim is to optimize and maintain, for reliable and forefront performance, experimental facilities and instrumentation, detectors, software and computing and network capabilities on the Resource’s 8+ beam lines at SSRL, capitalizing on the high SR x-ray performance of SSRL’s 3rd generation storage ring SPEAR3, and at the MFX station at LCLS. A multi-facility proposal mechanism facilitates access to complementary Cryo-EM and LCLS stations on-site at SLAC. With a specialized focus on user training, support and service, the Resource enables the scientific success for challenging and routine projects in the biomedical sciences.

摘要/摘要 - P30GM133894 同步辐射 (SR) 是一种极其明亮且可调谐的 X 射线源，可实现前沿结构分子生物学（SMB）的研究“同步加速器结构生物学”的目标。斯坦福同步辐射光源 (SSRL) 的资源”，以下简称简单来说就是“资源”，就是为用户提供访问集成的、成熟的 SMB 功能的机会最先进的同步加速器光束线设施，用于大分子晶体学、X 射线吸收/发射/成像光谱和小角度 X 射线散射/衍射。三个领域构成了该资源的三个技术运营核心。创建简化的用户访问，提供专门的用户支持和服务，培训用户，以及就这些专业但成熟的能力的科学效益进行宣传为生物医学研究界提供多种创新的访问机制。正在提供，包括访问核心的单技术和多技术方法，基于透明且稳健的外部同行评审流程。外展计划包括个人培训、研讨会、暑期学校、在途培训和由经验丰富的科学和技术人员支持临床部门。提供精简的科学、技术、培训、外展和行政材料以及其他相关信息的主要目的是优化和维护，以获得可靠和前沿的信息。性能、实验设施和仪器、探测器、软件和计算以及 SSRL 资源的 8 条以上光束线上的网络功能，利用高 SR X 射线 SSRL 第三代存储环 SPEAR3 的性能，以及 LCLS A 的 MFX 站。多设施提案机制有助于获得互补的 Cryo-EM 和 LCLS SLAC 现场站专门专注于用户培训、支持和服务。资源使生物医学领域具有挑战性的常规项目取得科学成功科学。