A Synchrotron Radiation Structural Biology Resource

同步辐射结构生物学资源

基本信息

批准号：
10579751
负责人：
KEITH O HODGSON
金额：
$ 26.59万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10579751
关键词：
Area Automation Biological Biomedical Research Clinic Collaborations Communities Complement Computer software Cryoelectron Microscopy Crystallography Data Data Analyses Data Collection Detection Development Education and Outreach Educational workshop Facility Accesses Funding Generations Goals Grant Health Human Image Imaging Device Individual Instruction Investments Laboratories Leadership Life Light Measurement Membrane Lipids Mentors Methodology Methods Molecular Biology National Institute of General Medical Sciences Peer Review Performance Privatization Process Productivity Recording of previous events Research Research Personnel Research Project Grants Resources Roentgen Rays Schools Science Services Site Source Spectrum Analysis Structure Synchrotrons Techniques Technology Time Training Training Programs Training Support United States National Institutes of Health Work X ray spectroscopy X-Ray Crystallography absorption base biological systems computer cluster computerized data processing data quality detector experience experimental study flexibility human disease innovation instrument instrumentation new technology novel therapeutics online resource operation outreach outreach program programs ranpirnase spectroscopic imaging structural biology success synchrotron radiation technological innovation theories tool web portal web-based tool x-ray free-electron laser

项目摘要

Summary/Abstract - P30GM133894 Synchrotron radiation (SR) is an extremely bright and tunable x-ray source that enables forefront research in structural molecular biology (SMB). The goal of “A Synchrotron Structural Biology Resource" at the Stanford Synchrotron Radiation Lightsource (SSRL), hereafter referred to as simply “Resource”, is to provide users access to integrated, mature SMB capabilities utilizing state-of-the-art synchrotron beam line facilities for macromolecular crystallography, x-ray absorption/emission/imaging spectroscopy and small angle x-ray scattering/diffraction. These three areas comprise the Resource’s three Technical Operations Cores. Special emphasis is to create streamlined user access, provide dedicated user support and services, to train users, and to perform outreach on the scientific benefits of the capabilities of these specialized, yet mature facilities to the biomedical research community. Multiple innovative access mechanisms are being provided, that include both single- and multiple-technique approaches to access the Cores, based on a transparent and robust external peer-review process. A multifaceted training and outreach program includes individual training, workshops, summer schools, on-the-road, and support clinic segments by experienced scientific and technical staff. A Resource web portal provides streamlined scientific, technical, training, outreach and administrative material and other relevant information. A principal aim is to optimize and maintain, for reliable and forefront performance, experimental facilities and instrumentation, detectors, software and computing and network capabilities on the Resource’s 8+ beam lines at SSRL, capitalizing on the high SR x-ray performance of SSRL’s 3rd generation storage ring SPEAR3, and at the MFX station at LCLS. A multi-facility proposal mechanism facilitates access to complementary Cryo-EM and LCLS stations on-site at SLAC. With a specialized focus on user training, support and service, the Resource enables the scientific success for challenging and routine projects in the biomedical sciences.

摘要/摘要-P30GM133894 同步加速器辐射（SR）是一种极其明亮且可调的X射线源，可实现最前沿结构分子生物学（SMB）的研究。 “同步结构生物学的目标资源“在斯坦福同步辐射光线（SSRL），以下称为简而大分子晶体学，X射线的最先进的同步器束线设备抽象/发射/成像光谱和小角度X射线散射/衍射。这些三个领域包括资源的三个技术操作核心。特别重点是创建精简的用户访问，提供专用的用户支持和服务，培训用户以及对这些专业但成熟的能力的科学益处进行宣传生物医学研究界的设施。多种创新的访问机制是提供的，包括单一技术和多技术方法来访问核心，基于透明且健壮的外部同行评审过程。多方面的培训和外展计划包括个人培训，研讨会，暑期学校，公路和由经验丰富的科学和技术人员支持诊所领域。资源网站提供精简的科学，技术，培训，外展和行政材料以及其他相关信息。主要目的是优化和维护，以实现可靠和最前沿性能，实验设施和仪器，探测器，软件和计算以及 SSRL资源的8+梁线上的网络功能，利用高SR X射线 SSRL的第三代存储环Spear3的性能以及LCLS的MFX站。一个多门启示式提案机制设施访问完整的Cryo-EM和LCLS SLAC现场的电台。专门关注用户培训，支持和服务，资源为生物医学中的挑战和常规项目带来了科学成功科学。