PRENATAL COCAINE, SMOKING AND OXYTOCIN IN HUMANS

人类产前可卡因、吸烟和催产素

• 批准号: 7716873
• 负责人: Karen M Grewen
• 金额: $ 0.37万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716873
• 关键词: Area; Brain; Cocaine; Computer Retrieval of Information on Scientific Projects Database; Cues; Fetal Cocaine Exposure; Functional Magnetic Resonance Imaging; Funding; Grant; Home environment; Hour; Human; Infant; Institution; K-Series Research Career Programs; Maternal Behavior; Measures; Monitor; Mothers; Oxytocin; Pharmaceutical Preparations; Physiological; Protocols documentation; Purpose; Research; Research Personnel; Resources; Smoking; Source; System; Training; United States National Institutes of Health; prenatal; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this K01 career development award is to provide training and supervised research in a new area of study. We will examine how cocaine use in pregnancy alters maternal physiological systems involved in maternal attachment formation in humans. Focus will be on dysregulation of maternal oxytocin activity, maternal behavior during video-taped infant interaction, and fMRI measures of maternal brain circuitry in response to infant cues. Subjects will be 48 mother-infant dyads(with prenatal cocaine use vs. drug naieve). Mothers will undergo an experimental lab with their infants, 24-hour monitoring in the home environment, and a short fMRI protocol.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 K01 职业发展奖的目的是在新的研究领域提供培训和监督研究。我们将研究怀孕期间使用可卡因如何改变参与人类母性依恋形成的母性生理系统。重点将放在母亲催产素活性的失调、婴儿互动录像中母亲的行为，以及母亲大脑回路对婴儿线索的反应的功能磁共振成像测量。受试者将是 48 名母婴组合（产前使用可卡因与未吸毒者）。母亲们将带着婴儿接受实验室实验、家庭环境中的 24 小时监测以及简短的功能磁共振成像方案。