HYPOXIA-INDUCIBLE FACTORS IN BPD

BPD 中的缺氧诱导因素

• 批准号: 7716092
• 负责人: Carl W White
• 金额: $ 2.26万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716092
• 关键词: Alveolar; Blood Vessels; Computer Retrieval of Information on Scientific Projects Database; Development; Funding; Gases; Gene Expression; Grant; Growth; Hypoxia; Hypoxia Inducible Factor; In Vitro; Institution; Newborn Infant; Phosphotransferases; Procollagen-Proline Dioxygenase; Proteins; Research; Research Personnel; Resources; Source; Structure of parenchyma of lung; United States National Institutes of Health; fetal; in vivo; pulmonary function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific aims: (1) Compare effects of hypoxia and normoxia in fetal and newborn lung tissue as to HIFs, HIF-related gene expression, and vascular growth-related kinase activities, and to evaluate the in vitro effect of HIF prolyl hydroxylase domain-containing proteins PHD inhibition on these activities. (2) Examine the effect of PHD inhibition on HIF proteins, HIF-related gene products, and vascular growth-related kinase activities in vivo. (3) Evaluate the effect of PHD inhibition on pulmonary function, gas exchange, and vascular and alveolar development

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 具体目标： （1）比较胎儿和新生儿肺组织缺氧和常氧对HIF、HIF相关基因表达、血管生长相关激酶活性的影响，评价HIF含脯氨酰羟化酶结构域蛋白PHD抑制的体外效果关于这些活动。 (2)考察PHD抑制对体内HIF蛋白、HIF相关基因产物和血管生长相关激酶活性的影响。 (3)评价PHD抑制对肺功能、气体交换以及血管和肺泡发育的影响