DIAGNOSTIC AND CLINICAL PATHOLOGY

诊断和临床病理学

• 批准号: 7715434
• 负责人: Shawn Patrick O'Neil
• 金额: $ 1.3万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-05 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715434
• 关键词: Acquired Immunodeficiency Syndrome; Anatomy; Animal Model; Arterial Disorder; Clinical Pathology; Colitis; Colon Carcinoma; Comparative Pathology; Computer Retrieval of Information on Scientific Projects Database; Condition; Diagnostic; Disease; Funding; Glomerulonephritis; Grant; Infection; Institution; Laboratories; Macaca mulatta; Modeling; Mycobacterium avium-intracellulare Infection; Pathogenesis; Play; Research; Research Personnel; Resources; Role; Scientist; Services; Simian Acquired Immunodeficiency Syndrome; Source; United States National Institutes of Health; human disease; model development; nonhuman primate; tumorigenesis

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Division of Comparative Pathology provides anatomic and clinical pathology services to the various Divisions of the Center, affiliated scientists, collaborative scientists, and other scientific investigators from the USA who utilize the resources of this center. The diagnostic laboratory plays a critical role in the recognition of certain natural diseases of captive nonhuman primates that may be developed into animal models for various diseases of humans. Examples of nonhuman primate models for human diseases that have been developed at the Center include simian AIDS, colitis and colonic carcinoma, and glomerulonephritis. AIDS pathogenesis studies, using the SIV/rhesus macaque model, remain a major focus of the research conducted in the Division of Comparative Pathology. More recently described conditions of nonhuman primates that are currently being investigated for model development include SV40-induced oncogenesis, arteriopathy in SIV-infected rhesus, cryptosporidial infection in rhesus, and the pathogenesis of Mycobacterium avium infection in SIV-infected rhesus.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 比较病理学部门为该中心的各个部门、附属科学家、合作科学家和来自美国的利用该中心资源的其他科学研究人员提供解剖和临床病理学服务。 诊断实验室在识别圈养非人类灵长类动物的某些自然疾病方面发挥着至关重要的作用，这些自然疾病可以开发成人类各种疾病的动物模型。 该中心开发的人类疾病非人类灵长类动物模型的例子包括猿猴艾滋病、结肠炎和结肠癌以及肾小球肾炎。 使用 SIV/恒河猴模型进行的艾滋病发病机制研究仍然是比较病理学部门进行的研究的主要焦点。 最近描述的非人类灵长类疾病目前正在研究用于模型开发，包括 SV40 诱导的肿瘤发生、感染 SIV 的恒河猴的动脉病、恒河猴的隐孢子虫感染以及感染 SIV 的恒河猴的鸟分枝杆菌感染的发病机制。