Core of Advanced Platform Technologies Used for Remediation and Exploration

用于修复和勘探的先进平台技术核心

基本信息

批准号：
10559558
负责人：
Erin Marie Baker
金额：
$ 26.61万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-03 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10559558
关键词：
Address Affect Algorithms Animals Biological Biological Models Blood Carbon Chemicals Communities Core Facility Data Data Collection Data Set Databases Decision Making Development Doctor of Philosophy Education Electron Microscope Electron Microscopy Electron energy loss spectroscopy Ensure Environment Environmental Pollutants Evaluation Genomics Hazardous Chemicals Health Human Human Resources Individual Ions Knowledge Laboratories Length Mass Spectrum Analysis Measurement Methods Modernization Molecular Monitor PSSO3 Penetration Phase Phenotype Poly-fluoroalkyl substances Population Procedures Protocols documentation Qualifying Reaction Reagent Research Research Personnel Resource Sharing Role Sampling Scanning Sex Differences Signal Recognition Particle Solid Spectrum Analysis Stable Isotope Labeling Superfund Techniques Technology Tissues Urine Variant Water Work X ray spectroscopy Zebrafish combinatorial community engagement dashboard detection limit genome sciences high resolution imaging improved innovation instrumentation interest ion mobility lipidomics metabolomics nanometer novel particle public database remediation species difference technology platform tool transcriptome sequencing transcriptomics translational engagement transmission process

项目摘要

ABSTRACT CAPTURE Responding to newly discovered environmental contaminants requires novel analytical approaches. The Core of Advanced Platform Technologies Used for Remediation and Exploration (CAPTURE) will provide analytical capabilities to the four projects in the NC State Superfund Research Center to enable rapid, comprehensive assessment of PFAS presence. CAPTURE is comprised of the Genomic Sciences Laboratory (GSL), the Analytical Instrumentation Facility (AIF), and the Molecular Education, Technology, and Research Innovation Center (METRIC) at NC State, which have over $25M in modern instrumentation and are operated by more than 20 PhD-level, highly qualified personnel. These capabilities provide CAPTURE with the ability to explore the diversity of scientific questions with a broad range of measurements including RNA-seq, materials characterization, and mass spectrometry analyses for the known and unknown per- and polyfluoroalkyl substances (PFAS). New methods and reagents will result from this work which will enable and inform the entire scientific community about PFAS in the environment. Additionally, CAPTURE will enhance interactions among Center projects and other cores, increasing their impact by ensuring synchronization of exposure measurements and increasing their value in decision-making, translation, and community engagement.

抽象的捕获响应新发现的环境污染物需要新颖的分析方法。用于修复和探索的高级平台技术的核心（捕获）将为NC州超级基金研究中心的四个项目提供分析能力，以启用快速，全面评估PFA的存在。捕获由基因组组成科学实验室（GSL），分析仪器设施（AIF）和分子教育，北卡罗来纳州的技术和研究创新中心（公制），现代有超过2500万美元仪器，由20多个博士学位，高素质的人员运营。这些功能提供了捕获的能力，能够探索科学问题的多样性测量范围包括RNA-Seq，材料表征和质谱法分析已知的和未知的人类和多氟烷基物质（PFA）。新方法和试剂将由这项工作造成，这将使并告知整个科学界环境中的PFA。此外，捕获将增强中心项目之间的互动其他核心，通过确保暴露测量和提高他们在决策，翻译和社区参与方面的价值。