Delaware Center for Musculoskeletal Research

特拉华肌肉骨骼研究中心

• 批准号: 10091019
• 负责人: DAWN M ELLIOTT
• 金额: $ 235.01万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10091019
• 关键词: Address; Affect; Aging; Area; Basic Science; Biological; Biological Process; Biology; Cell Communication; Cells; Centers of Research Excellence; Clinical; Clinical Research; Collaborations; Communities; Complement; Cues; Degenerative polyarthritis; Delaware; Equipment; Extramural Activities; Faculty; Fostering; Functional disorder; Funding; Goals; Grant; Health; Health Status; Homeostasis; Inflammation; Injury; Interdisciplinary Study; Leadership; Mechanics; Mentors; Metabolism; Molecular; Muscular Atrophy; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal System; Organ; Osteoporosis; Phase; Research; Research Personnel; Research Project Grants; Research Support; Role; Signal Transduction; Structure; Technical Expertise; Testing; Therapeutic Intervention; Tissues; Training; Universities; career development; faculty mentor; functional restoration; improved; mechanical force; multidisciplinary; pre-clinical research; programs; recruit; repaired; success; synergism

PROJECT SUMMARY/ABSTRACT The musculoskeletal system has both mechanical and biological functions—it generates, transmits, and supports forces, and it regulates organ-level homeostasis and whole-body metabolism. The mechanics and biology of the musculoskeletal system are inextricably intertwined and long-ranging, where mechanical cues, molecular signals, and cell interactions affect each other across multiple scales, from the body, to organ, tissue, cell, and molecule levels. Progress in musculoskeletal research depends on addressing the mechanics and biology of adjacent organs, and evaluating the effects of injury as well as aging. Identifying the mechanisms underlying musculoskeletal health and musculoskeletal disorders (e.g., osteoarthritis, osteoporosis, muscle wasting, post-traumatic repair, degeneration) therefore requires a research paradigm that addresses the synergies within the musculoskeletal system and combines both mechanical and biological approaches across multiple scales. The Delaware Center for Musculoskeletal Research (DCMR) will support basic and preclinical research on the central theme of musculoskeletal health—from the level of the entire body to the actions of key cells and molecules—with emphasis on understanding the mechanisms by which physical and biological cues influence tissue structure and normal function and dysfunction, and identifying potential therapeutic interventions. The proposed DCMR will: Aim 1: Accelerate fundamental musculoskeletal research by supporting synergistic and multidisciplinary Research Projects. Aim 2: Galvanize capabilities for musculoskeletal research by establishing a Multiscale Assessments Research Core. Aim 3: Amplify the impact of musculoskeletal research through faculty mentoring, expansion, and retention. Completion of this 5-year Phase I COBRE will build cross-cutting and synergistic research collaborations across multi-scale and multidisciplinary Research Projects and establish a state-of-the-art Research Core. The DCMR, which will focus on fundamental discovery and preclinical research, will complement the outstanding translational and clinical musculoskeletal research programs at Delaware, creating a comprehensive basic-to- clinical research pipeline at UD. Through fostering cross-cutting and convergent research partnerships, the DCMR aims to substantially reduce the burden of musculoskeletal disorders and improve musculoskeletal health.

项目摘要/摘要 肌肉骨骼系统具有机械功能和生物学功能 - 它产生，传输和 支撑力，并规范器官级的稳态和全身代谢 肌肉骨骼系统的生物学是不可交织和远程的无情，机械提示， 分子信号和细胞相互作用在从身体到器官，组织，组织，组织的多个尺度上相互影响。 细胞和分子水平。 相邻器官的生物学，并评估损伤和衰老的影响。 潜在的肌肉骨骼健康和肌肉骨骼障碍（例如骨关节炎，骨质疏松症，肌肉 因此，浪费，创伤后修复，变性）因此需要一个针对您的研究范式 肌肉骨骼系统中的协同作用，并将机械和生物学结合在一起 多个量表。 特拉华州肌肉骨骼研究中心（DCMR）将支持基本和临床前 研究中心的研究主题是肌肉骨骼健康的主题 - 从整个身体的水平到动作 关键细胞和分子 - 强调物理和物理的机制 生物提示会影响组织组织以及正常功能和功能障碍，并确定潜力 拟议的DCMR将： 目标1：通过支持协同和多学科的基本肌肉骨骼研究加速基本的肌肉研究 研究项目。 目的2：通过建立多尺度评估来镀锌能力进行肌肉骨骼研究 研究核心。 目标3：通过教师指导，扩张和退位来扩大肌肉骨骼研究的影响。 压缩这五年的I COBRE将建立切割和切割和协同研究协作性 在多尺度和多学科的研究中，并建立了最先进的研究核心核心核心核心核心核心核心核心核心核心核心核心核心核心。 DCMR将专注于基本发现和临床前研究，将补充OutStang 特拉华州的翻译和临床肌肉研究计划，创建了一项汇编基础 UD的临床研究管道。 DCMR旨在大大减轻肌肉骨骼障碍的负担并改善肌肉骨骼 健康。